The SuperArgus PET/CT system incorporates state-of-the-art detectors as well as the latest advancements in electronics, resulting in one of the most sensitive systems on the market today.
The phoswich detectors are key to the unique features of the system:
- Provide true depth of interaction (tDOI) information resulting in
- Highest resolution on the market; ≤1.0mm
- Uniform resolution across the entire field of view, with the field of view filling the majority of the bore of the system due to the parallax error correction
- Highest sensitivity on the market; 11% at 100-700keV
- Real-time imaging; up to 2.5msec frame rate if desired
The advanced electronics allow for the following:
- Dynamic imaging; possible due to time-stamp acquisition electronics
- Parallel electronics for acquisition
Combined the phoswich detectors and electronics allow the SuperArgus system to be the first capable of conscious imaging in awake animals; this capability opens up endless possibilities of neuro-cognitive research which has yet to be explored.
In addition to awake animal imaging, the unique features of the SuperArgus system allow for sensorless cardiac imaging, possible on both a single animal but also on multi-animal imaging sessions.
Finally, a research and development consortium spread across Spain and the US has worked to develop Multiplex PET (mPET) capabilities on the SuperArgus system. That is the ability to detect two radiotracers simultaneously during the same imaging session. The software is then able to deconvolve the tracers, displaying the individual reconstructions.
Sedecal has optimized the electronics and algorithms to perform precise image reconstruction very quickly.
These are some of the more common reconstructions available on the system:
- FBP (Filtered Back Projection) completed in less than 5 seconds
- 2D OSEM (Ordered Subset Expectation Maximization) completed in less than 1 minutes
- 3D OSEM completed in less than 2 minutes
Taken as a whole, the SuperArgus systems provide best-in-class image quality, as seen here on an 18F PET bone scan image:
The SuperArgus system may be configured to be PET-only or PET/CT. There are three models available r – 100mm bore for mouse, rats or marmosets up to 3kg; R – 160mm bore for multi-animal imaging, as well as rabbits up to 6kg; or P – 260mm bore for non-human primates, canine or porcine up to 10kg. Each model can be configured with 2, 4, or 6 PET rings. Please review the Tech Spec document for additional information on fields of view.
While Sedecal has invested a great deal of time in developing the phoswich detectors, and updated electronics for PET imaging, they have also focused on updating the CT technology within the SuperArgus systems as well. Updates have focused on lower doses of radiation, faster scan times, higher resolution images and advanced applications. These updates further the systems functionality in longitudinal studies, by minimizing the exposure of the animals to radiation throughout the course of a study.
The SuperArgus systems (r and R models only) have been designed to be self-shielded, meeting the FDA guidelines for CT scanners. This means that there are no special room requirements, or additional shielding required. The SuperArgus systems can easily be placed within existing laboratory environments, imaging core, or within an animal facility.
The animal handling systems of the SuperArgus system have been well thought out and designed to have integrated anesthesia, heating, and physiological monitoring. Multi-animal handling systems are available for all models, and custom configurations are possible.