The SuperArgus PET/CT from Sedecal is a fully functional integrated system combining modern technologies for both PET and CT providing molecular imaging on a wide variety of pre-clinical animal models. The development of this system is a major breakthrough in high performance functional and molecular imaging technologies for biomedical research. The dual modality configuration delivers faster scan times with superior image resolution, improved localization and quantifiable data. The SuperArgus PET/CT has been designed with a user-friendly operator interface and easy animal positioning.

SuperArgus PET/CT

The new SuperArgus PET/CT incorporates state of the art technology as the latest evolution of the Argus PET/CT family of scanners.

The core of the new scanner combines the unique Phoswich PET detector technology, which provides true depth-of-interaction (tDOI), with the largest field of view on the market. The Super Argus PET/CT may be configured to image small animals such a mice (2 rings, rats and rabbits (2, 4 or 6 rings) all the way up to non-human primates, dogs, and pigs (6 rings).

Updates to the CT technology have focused on lower doses of radiation, faster scan times, higher resolution images and advanced applications.

The SuperArgus has been designed to meet the demanding needs of the busy laboratory with improved animal handing, including a multi-animal bed which allows for high throughput imaging of up to 10 mice at the same time.

SuperArgus PET/CT Main Achievements

  • First combined PET/CT small animal scanner
  • First small animal PET scanner with depth-of-interaction DOI (parallax correction)
  • First small animal PET scanner with Full 3D True Response System Model in 3D OSEM reconstruction.
  • First Ultra Fast 3D OSEM reconstruction without a cluster
  • First and the only one with REAL TIME PET IMAGING

SuperArgus PET/CT/MR System Overview

The core of the SuperArgus PET/CT system is its Phoswich detector technology, which provides true depth-of-interaction (tDOI) or parallax-correcting capability, implemented through dual-scintillator phosphor sandwich detector modules.

Along with this advanced crystal technology, the SuperArgus PET/CT  has the best in its class acquisition electronics with the following differentiating advantages:

  1. Highest resolution in the market
  2. Uniform resolution across the entire FOV
  3. Highest sensitivity per centimeter
  4. Highest dynamic time frame resolution: 2.5 ms
  5. Time stamp acquisition electronics
  6. Fully modular electronics.
  7. Parallel electronics acquisition, non multiplexing
  8. Superior image uniformity
  9. Faster scan times
  10. Fully integrated components
  11. Compact footprint

High Throughput

  • High throughput, the highest NEC in the market for muti-animal studies
  • Fast scanning with low dose
  • 3 mice in the rabbit bed
  • Zr 89 antibody  compound
  • 30 µCi activity per animal and 5 minutes acquisition

PET/CT REVIEWS

4 Bed System

  • Real time Image quality control
  • Dynamic studies with time frame of 2.5 ms
  • Immediate Go/ No-Go studies
  • First-shot Imaging
  • Instantaneous motion correction
  • Cardiac gated imaging sensor less
  • Awake animals PET imaging
  • Fully modular detectors technology
  • Biopsy guided by PET Imaging
  • Radiotherapy Image guided
Motion Correction

  • The movement is tracked using small fiducial markers
  • They are spheres < 1 mm diameter FDG filled
  • The acquisition could be dynamic or static

ct scanners reviews

Video of PET in Awake Animals

Small ANIMALS RABBITS 

The Results

50 fps

20 ms

Sagittal

Coronal

Axial

Phoswich modules with 4 lines of response virtually eliminate parallax effect (DOI) with 3D-OSEM reconstruction

Higher detector sensitivity: two concentric detector rings instead of one

Resolution uniformity is considerably improved  with DOI correction as radial source position increases.

More accurate quantitation of smaller ROIs at the edge of the FOV

System Matrix Response (SMR) corrects for:

  • positron range
  • non-collinearity, interaction of gammas with scintillator crystals
  • scintillator response
  • detector electronics

fASTEST SCANNER

SuperArgus PET/CT: tDOI in vivo Results

Analatic Reconstruction

Iterative Reconstruction

FORE=FSP                                           3D OSEM

2D OSEM                                           3D OSEM

ModelArgus CompactSuperArgus PET/CT 2rSuperArgus PET/CT 4rSuperArgus PET/CT 6rSuperArgus PET/CT 2RSuperArgus PET/CT 4RSuperArgus PET/CT 6RSuperArgus PET/CT 4PSuperArgus PET/CT 6P
AnimalsMice onlyMice, rats and marmosetsMice, rats and marmosetsMice, rats and marmosetsMice, rats, marmosets, rabbits (3 kg)Mice, rats, marmosets, rabbits (3 kg)Mice, rats, marmosets, rabbits (3 kg)Non-human primates; canine; porcine, murine (10 kg)Non-human primates; canine; porcine, murine (10kg)
Dynamic AFOV100 mm220 mm220 mm220 mm350 mm350 mm350 mm650 mm650 mm
Static AFOV100 mm50 mm100 mm150 mm50 mm100 mm151 mm100 mm150 mm
TFOV50 mm80 mm80 mm80 mm120 mm120 mm120 mm210 mm210 mm
Bore size55 mm90 mm90 mm90 mm160 mm160 mm160 mm260 mm260 mm
Detectors322856844896144128192
DOI crystals10816946418928283921622432448486724326464896
ModelBasicAdvancedExtended
RotationContinuosContinuousContinuous
FOV70 x 180 mm120 x 350 mm210 x 650 mm
ZoomNoYesYes
Acquisition time15 s15 s15 s
Spatial resolution50 µm15 µm20 µm
Flat panelCMOS and Cs plateCMOS and Cs plateCMOS and Cs plate
FPS868686
Detector Active Area12 x 15 cm23 x 15 cm29 x 23 cm
Number of pixels1944 x 15363072 x 19443888 x 3072
X Ray Energy peak50 kV130 kV130 kV
Source spot35 µm 7 to 100 µm 7 to 100 µm
Max Power50 W65 W65 W
X Ray ProtectionAuto shielded according FDA

Cardiovascular

    1. Cardiac Function
      • Pet/CT Imaging: PET/CT Imaging combines the functional nuclear imaging of positron emission tomography (PET) with the precision of an x-ray computed tomography (CT) scanner to produce accurate anatomic renderings allowing for visualizing metabolic or biochemical activity within the body. From a cardiovascular standpoint, PET/CT is a vital tool used for quantification of cardiac perfusion and assessment of coronary anatomy which has previously been underutilized due to costs and lack of readily available equipment.

Cancer

    1. Tumor Imaging
      • Pet/CT imaging: PET/CT Imaging combines the functional nuclear imaging of positron emission tomography (PET) with the precision of an x-ray computed tomography (CT) scanner to produce accurate anatomic renderings allowing for visualizing metabolic or biochemical activity within the body. From an oncological standpoint, PET/CT allows for the accurate visualization of tumor specific metabolism as well as the capability of distinguishing malignant cells from adjacent normal tissue based on established differences in biochemical activity.

Please contact us at info@scintica.com to request the most up to date images and information for specific research applications.