Applying and maintaining physiological pressures in cannulated blood vessels is a key factor in vascular research. Precise control of pressure, with or without intraluminal flow, is a paramount necessity. Our pressure instrumentation is designed to establish, control, and measure the intraluminal pressure during an experiment.
Our vessel chambers are precision machined from inert plastic that has chemical and physical properties superior to acrylics, and is more economical than stainless steel.
Pressure arteriography is the gold-standard for quantifying function, reactivity and mechanics in isolated perfused blood vessels. When embarking on pressure arteriography, many factors warrant consideration. In addition to the requisite surgical skills for isolating and cannulating small arteries, proper instrumentation is also paramount. Pressure arteriography, while a powerful tool, comprises a number of different hardware and software components that must integrate and operate properly.
Living Systems Instrumentation is the only provider for complete pressure arteriography systems that not only allow the researcher to quickly get their experiments up and running, but ensures the quality and reproducibility of the data collected. Not only is LSI the pioneer in pressure arteriography, they also have a long and comprehensive publication history that speaks to their established and state-of-the-art arteriography systems.
While there are other options for individual arteriograph components available from various sources, these require significant investment in time to optimize, refine and “debug” that delays maintaining a regular experiment schedule and often lack the robustness required for data integrity and confidence.
And with their long experiential history and comprehensive knowledge base, Living Systems is always available to assist and support all of your arteriography needs.
As with any research protocol, the priority is to focus on your data, not your instruments. So if you are considering pressure arteriography, you can rely on the tried, tested and true systems offered by Living Systems Instrumentation to deliver accurate results in a timely and uncomplicated manner.
Constant Pressure
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Pressure Artiograph
Constant Pressure & Flow
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Parts of a Pressure Arteriograph
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The CH-1 is Living System’s most versatile chamber design, and is ideal for experiments requiring vessel diameter measurements. This chamber is well-suited for use in widefield and confocal fluorescence microscopy, or standard transmitted light microscopy, and allows visualization of blood vessels as small as 30 µm in diameter. Living System’s temperature controller (TC-09S) can be used to directly control or monitor bath temperature. For monitoring or controlling bath temperature, a bath thermistor sensor (THRS) is also required. Check out Living System’s self-heated single vessel chamber package (CH-1-SH) for self-heating temperature control applications.
Specifications Bath Volume: 3-8 ml |
Watch our video here: |
| The CH-2 chamber is used to optimize experimental throughput, allowing two vessels to be mounted side by side. This chamber can be used for wide-field or confocal fluorescence microscopy, as well as standard transmitted light microscopy. The dual vessel chamber is ideal for bioassay work where perfusate from one vessel is routed to the adjacent vessel. It allows visualization of blood vessels as small as 30 µm in diameter. Living System’s temperature controller (TC-09D) can be used to directly control or monitor bath temperature. For monitoring or controlling bath temperature, a bath thermistor sensor (THRS) is also required for each of the two vessel baths. Check out Living System’s self-heated dual vessel chamber package (LS-CH-2-SH) for self-heating temperature control applications.
Key Features
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| The CH-1-LIN Linear Alignment Vessel Chamber represents Living System’s latest design for their arteriograph line. Living System’s has incorporated three-axis (X-Y-Z) linear controls on both the proximal and distal cannulae arms. Cannulae can be easily aligned in three-dimensional space in just seconds using the simple thumb screws. No special tools are needed. The chamber is ideal for new users of pressure arteriographs, because alignment of the cannulae has been greatly simplified.
Key Features:
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| In some cases, such as when using expensive peptides or other drugs, bath superfusion is not an option. These applications call for minimizing the volume of bath fluid to keep the amount of reagents used to a minimum. In these cases, heating the bath to physiological temperatures can be problematic. However, with Living System’s single vessel chamber (CH-1) and temperature controller (TC-09S), you can heat the vessel chamber directly to physiological temperatures. This package contains everything needed to conduct these self-heating studies in a single vessel chamber.
Package Components:
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| Living System’s CH-2-SH package is designed to provide dual vessel chamber users an option for running experiments at physiological temperatures in the absence of bath superfusion. This package contains everything needed to run dual vessel chamber studies by heating the dual vessel chamber (CH-2) directly to the desired temperature.
Package Components:
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| Living System’s CH-1-LIN-SH contains everything needed to run vessel chamber studies by heating the linear alignment single vessel chamber directly to the desired temperature.
Includes:
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| Suitable for cannulation & perfusion of large hollow organs, such as blood vessels (e.g. aorta, carotid), intestine, airway, mid-gut, or colon. The unique size of this chamber also makes it suitable for other applications, such as insect mid-gut cannulation.
Key Features
Notes
Specifications Chamber Material: Delrin, stainless steel
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| This axially rotating single vessel chamber rotates the vessel to image adjacent cell structures using confocal or Nomarski optics. This is useful for injections of caged agents and observation after inversion. The angled cannula holders bring the vessel close to the coverslip for simultaneous diameter and fluorescence measurements, and pressure and perfusion is maintained during the rotation.
Optional standard cannula holders (RCH) can be used in this chamber. It is ideally suited for larger diameter vessels with longer lengths because it has a longer bath. Advantages
Specifications Bath Volume: 6–10 ml |
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| This chamber is designed for rapid freezing or fixation of a cannulated and pressurized vessel for biochemical or morphometric studies.
One section of the CH-1-QT contains the experimental chamber where a superfused vessel may be examined for its diameter responses to pharmacological agents, pressure, flow, etc. A glass coverslip allows visualization of the vessel for lumen diameter and wall measurements using the video dimension analyzer (VDA-10). The other section has a well that a removable tray fits into. A lever arm is used to quickly transfer (~1 sec) the vessel and its tubing connections from the chamber to the tray. In this way, the physiological state of the vessel (pressure, myogenic tone, etc) can be maintained during the freezing or fixation process. The CH-1-QT will readily tolerate the low temperature of an acetone-dry ice freezing solution, liquid nitrogen, or various fixing solutions. Specifications Bath Volume: 6-10ml |
 Watch Video Here:
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This miniature perfusion chamber is ideal for cellular physiology studies requiring bath superfusion in a low volume. The chamber fits on the stage of an inverted microscope. Mounting holes are included for inflow and outflow tubes. In addition, you can use magnetic accessories by attaching them to the embedded metal block. Does not include magnetic tube holder accessory. Specifications Base: Width: 44.5 mm Length: 88.9 mm Thickness: 6.4 mm |
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| This versatile sealed singe vessel chamber can be used for long-term vessel perfusion, vessel culture, gene transfer, remodeling studies and extravascular compression.
Features
Specifications Bath Volume: 3-8ml |
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| This is the self-heated package containing Living System’s CH-1-AU Sealed Single Vessel Chamber.
Package contains:
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The PM-4 is ideally suited for isolated, perfused vessel studies to aid the investigator in ensuring that a perfused vessel is exposed to a desired physiological pressure. The device has two pressure input channels, enabling the measurement of upstream and downstream pressure, average pressure, and pressure differential across a cannulated blood vessel. It can also be used for measuring the pressures at two locations in a vessel bed or isolated tissue. In conjunction with Living System’s pressure servo controller (PS-200), a transmural vessel pressure or a perfusion pressure may automatically be maintained during perfusion. The PM-4 also features four analog voltage outputs, which can be used to record pressure on both pressure channels, the pressure differential between the two pressure inputs, and the average of both pressure inputs. Includes two pressure transducers (PT-F). Specifications Pressure range: 0 to 200 mmHg; 0.1 mmHg resolution; ± 1% linearity; 3 |
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| The PM-P-1 is designed to accurately monitor and subsequently record any single physiological pressure. It is ideal for use in many settings and requires no electrical outlet. It features an analog voltage output that can be recorded on your data acquisition system and comes equipped with long life batteries. A PT-F Pressure Transducer is included.
Specifications
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| The pressure servo controller with peristaltic pump is used to precisely control the intravascular pressure in isolated cannulated blood vessels. Many other uses are also possible, including maintaining pressure in isolated organ beds, gastrointestinal tissue, urinary tract, or lymphatics. This instrument is ideally suited for examination of myogenic responsiveness of isolated cannulated blood vessels.
Use the PS-200 to achieve either a constant pressure (pressure mode; 0 to 200 mmHg) or a constant flow rate (flow mode; 3 µl/min to 2.4 ml/min, depending on tube set used—see FC-TS). The PS-200 comes with one piece of FC-TS-031 tubing, one piece of FC-TS-093 tubing, and one PT-F pressure transducer. In the pressure mode of operation, a flow-through pressure transducer placed in-line with the blood vessel, or other biological preparation, senses the pressure and a miniature peristaltic pump operates to maintain pressure at the user-specified set-point. In the flow mode of operation, the peristaltic pump supplies a user-defined constant flow rate, and the pressure transducer monitors perfusion pressure. Pressure is indicated directly in mmHg on a digital panel meter in both modes, and is available as an analog output voltage for data acquisition. Pressure or flow set-points may also be programmed through an external voltage signal applied to the instrument. Specifications
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| This miniature peristaltic pump delivers precise volume flow rates over a range determined by the setting of two calibrated potentiometer controls, and the tube set size chosen. It is similar to the pump used in the pressure servo control unit (PS-200).
Features:
Specifications Volume flow range: 3 µl/min–2.4 ml/min Power DC supply or |
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| The FI-1 provides a digital readout of the flow rate delivered by the FC flow control pump or the PS-200 pressure servo control pump. Flow rate can be monitored directly on the front-panel meter in µl/min, or using the analog voltage output signal, which is compatible with most data acquisition systems. The FI-1 also has a connector that enables remote control of flow rate using a D/A output or other analog voltage source.
Specifications Flow rate: 0–25 through 0–500 µl/min ranges |
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| This quality peristaltic pump is ideal for vessel bath superfusion. The pump includes two flow heads, one for delivering solution to the bath (inflow), and one for removing fluid from the bath (outflow).
Use INFLOW-IT-44-PKG4 tubing for the inflow side; Features: Specifications Typical Applications: +Superfusion of vessel and tissue baths +organ perfusion |
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| This quality peristaltic pump is ideal for vessel bath superfusion. The pump includes four flow heads which can be configured in several ways.
For example: Use INFLOW-IT-44-PKG4 tubing for inflow side; Use OUTFLOW-IT-48-PKG4 tubing for outflow side Specifications Typical Applications: +Superfusion of vessel and tissue baths +organ perfusion |
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| Living System’s thermal circulating bath is an economical heating circulator that includes the immersion heater unit, water bath, and circulating pump. The unit has a small footprint and low profile. Living System’ssearched many suppliers before we arrived at this unit, which delivers solid performance and economical prices.
Specifications Reservoir capacity: 6 L |
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| Living System’s temperature controllers feature unsurpassed thermoregulatory performance. A novel control algorithm results in quicker time to reach set point (6–10 min, from 22 ºC to 37 ºC). Living System’s temperature controllers now feature analog outputs that produce signals compatible with most data acquisition systems. The thermostat control can also be disabled, allowing the TC-09S to be used as a temperature monitoring and recording device (using the analog output).
The TC-09S is designed to control the bath temperature in Living System’s CH-1 single vessel chambers under steady-state conditions, when bath superfusion is not used. This is particularly useful when you have a stagnant bath with a HEPES or MOPS buffered saline solution. The temperature controller is not able to regulate bath temperature in the presence of bath superfusion. In that case, it is preferable to use a heat exchanger in your superfusion line to warm the bath saline just before it enters the vessel bath. Specification Power: 120 V or 220 V |
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| Living System’s controllers feature unsurpassed thermoregulatory performance. A novel control algorithm results in quicker time to reach set point (6–10 min, from 22 ºC to 37 ºC). Living System’s temperature controllers now feature analog outputs that produce signals compatible with most data acquisition systems. The TC-09D has two heating controllers that can be used to regulate the bath temperature in the two baths of our CH-2 vessel chambers independently. The thermostat control can also be disabled, allowing the TC-09D to be used as a temperature monitoring and recording device (when using the analog output). Panel controls allow for regulating the bath temperature of both chambers, chamber 1 only, chamber 2 only, or monitor only (no temperature control).
The TC-09D is designed to control the bath temperature in Living System’s CH-2 dual vessel chambers under steady-state conditions, when bath superfusion is not used. This is particularly useful when you have a stagnant bath with a HEPES or MOPS buffered saline solution. The temperature controller is not able to regulate bath temperature in the presence of bath superfusion. In that case, it is preferable to use a heat exchanger in your superfusion line to warm the bath saline just before it enters the vessel bath. Specification Power: 120 V or 220 V |
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| This meter provides a display of the temperature sensed by any of our thermistor temperature sensors. The THS-TEE sensor plugs directly into the TH-M meter. If you would like to monitor the temperature in one of our vessel baths using the THRS sensor a special cable is also required. |  |
| pH Meter
This high quality pH meter provides a continuous readout of pH. The pH electrode connects to the meter via a BNC connector. Use with PH-E or PH-TEE electrodes. Specifications
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| pH Miniature Electrode
This miniature pH electrode allows continuous pH monitoring in the bath solution of our vessel chambers. The PH-E is designed to fit inside the accessory port on the top of our standard vessel chamber covers. Reference solution is included. Specifications
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| pH-TEE Miniature Electrode Flow-Thru Min Tee
This miniature electrode provides continuous pH monitoring and can be placed in-line with the flow path, such as with perfusate or superfusate connections of cannulated vessel chambers. Equipped with luer-lock male fittings, it is compatible with all pH meters. This electrode can also be used in combination with our in-line “tee-mounted” thermistor (THS-TEE) for combined temperature and pH measurements. Reference solution included. Standard BNC termination; connects with most pH meters (see PH-M). Specifications
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| Video Camera – HDMI
These high-quality video cameras are perfect for measuring blood vessel diameter using Living Systems Instrumentation video dimension analyzer (VDA-10), which only processes the luma portion of the video signal (“gray scale”), regardless of camera type (color or monochrome) used. With this camera package, the HDMI camera output is converted to the standard composite video signal that is delivered to Living Systems VDA-10 over a BNC cable. This package contains the following items: video camera, HDMI cable, and HDMI to composite (analog) video converter. Note that the HDMI signal does not go directly to a monitor; it must pass through the composite video converter to be processed by the VDA-10. Specifications
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| Video Dimension Analyzer
This hardware edge detector tracks blood vessel diameter, and left and right wall thicknesses using an analog video signal. The principle of the instrument is based on sensing optical density changes of the vessel image at a chosen scan line seen on the TV monitor. The VDA-10 is well-suited for applications where a recording of blood vessel diameter and wall thickness is required. The VDA-10 tracks vessels ranging from 50 to 350 µm in diameter. In some cases, particularly larger vessels, or those with thick walls, only the outside diameter can be measured. These measurements are displayed on digital panel meters, and analog voltage outputs provide signals suitable for recording using most popular lab data acquisition systems (e.g., DAQ-PRO-U). Changes in blood vessel dimensions (constriction or dilation) are followed in real time. Applications
Features
Specifications
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| Living System’s offer 4 packages (1, 2, 4 or 8 channels) that are useful for applications requiring electric field stimulation. Each package includes a constant current stimulator(s), power supply cabinet, computer interface card, CATSTIM software, and interface cables. The output of each stimulator is accessible via a BNC connector.
Features
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| The extravascular pressure (EvP) in the sealed chamber is sensed by a solid-state pressure transducer. The signal from this transducer is connected to the pressure control unit where it is compared with either the internal pressure signal set by the pressure dial, or one of the external pressure signals fed into either the function generator or signal generator input jacks. Any difference between these two signals regulates the electronic servo valve output pressure so that the two pressures are the same.
Internal Pressure Signal Mode The signal corresponding to the pressure dial setting calibrated in mmHg establishes the extravascular chamber pressure. This pressure is sustained until a new pressure is selected. The panel meter reading shows the chosen extravascular pressure in mmHg which can be accessed for data acquisition at the rear panel pressure signal jack. External Pressure Signal Mode Various extravascular pressure waveshapes can be created to match external input signals in this mode. The actual extravascular pressure can be accessed for data acquisition at the rear panel pressure signal jack. Specifications
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| Living System’s Trinocular Inverted Microscope is an great choice for a vascular biology laboratory. It includes many features like AIS infinity corrected optical components, and delivers solid return.
Benefits:
Specifications Light Path: Binocular: 100% eyepieces Trinocular: 20% eyepieces/80% photo tube Interpupillary Distance: 48-75 mm Eyepieces: 10X EWF focusable 22 mm field of view 48-75 mm aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaainterpupillary distance; ±5 diopter adjustments; eyepieces accept 26 mm reticles General: Power: 100-240 V, 60 Hz; Fuse 2 A Warranty: 5 Year Shipping Dimensions: 34 aapounds, 19” x 16” x 26” |
  
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| The signal generator provides extravascular sinusoidal or pulse pressure (EvP) waveshape signals to the sealed chamber via a cable connection to the EV-1 when used in external signal mode. User-friendly pushbuttons are used to program upper and lower limits of the pressures as well as pulses per minute and other parameters that may best suit the experimenter’s protocol.
Specifications Sine: Extravascular systolic & diastolic pressure ranges: 0–250 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa mmHg* Pulse rate: 30–360 pulses/min*
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Irène R. Chassagnon, Claudia A. McCarthy, Yanni K.-Y. Chin, Sandy S. Pineda, Angelo Keramidas, Mehdi Mobli, Vi Pham, T. Michael De Silva, Joseph W. Lynch, Robert E. Widdop, Lachlan D. Rasha, and Glenn F. King
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Involvement of Epithelial Na+ Channel in the Elevated Myogenic Response in Posterior Cerebral Arteries from Spontaneously Hypertensive Rats
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Effect of Stilbenoid Polyphenols on Resistance Artery Structure and Mechanical Properties in the Spontaneously Hypertensive Heart Failure Rat
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Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
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Collateral Reactivity During Hypertension and Aging: Understanding the Function of Collaterals for Stroke Therapy.
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Automated Non-invasive Video-Microscopy of Oyster Spat Heart Rate during Acute Temperature Change: Impact of Acclimation Temperature.
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Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging
DuPont, J.J., McCurley, A., Davel, A.P., McCarthy, J., Bender, S.B., Hong, K., Yang, Y., Yoo, J.K., Aronovitz, M., Baur, W.E., Christou, D.D., Hill, M.A., and Jaffe, I.Z.
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Assessment of Basilar Artery Reactivity in Stroke and Subarachnoid Hemorrhage Using Wire Myograph.
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PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats
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Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency
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Lankadeva, Y. R., Singh, R. R., Moritz, K. M., Parkington, H. C., Denton, K. M. and Tare, M. Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep. (2015). Circulation. 131 (3): 280-288.
Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction
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Mechanism of hydralazine-induced relaxation in resistance arteries during pregnancy: Hydralazine induces vasodilation via a prostacyclin pathway
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Perivascular Adipose Tissue: A Novel Regulator of Vascular Tone in the Rat Pregnancy
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Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat
Mazzuca, M. Q., Mata, K. M., Li, W., Rangan, S. S. and Khalil, R. A. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. (2015). J Pharmacol Exp Ther. 352 (2): 291-304.
Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes
Nieves-Cintron, M., Nystoriak, M. A., Prada, M. P., Johnson, K., Fayer, W., Dell’Acqua, M. L., Scott, J. D. and Navedo, M. F. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. (2015). J Biol Chem. 290 (12): 7918-7929.
Mechanisms of Acute Alcohol Intoxication-Induced Modulation of Cyclic Mobilization of [Ca(2+)] in Rat Mesenteric Lymphatic Vessels
Souza-Smith, F. M., Kerut, E. K., Breslin, J. W. and Molina, P. E. Mechanisms of Acute Alcohol Intoxication-Induced Modulation of Cyclic Mobilization of [Ca(2+)] in Rat Mesenteric Lymphatic Vessels. (2015). Lymphat Res Biol. 13 (2): 93-99.
GRK2 targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling
Tutunea-Fatan, E., Caetano, F. A., Gros, R. and Ferguson, S. S. GRK2 targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling. (2015). J Biol Chem. 290 (8): 5141-5155.
Impact of short-term treatment with telmisartan on cerebral arterial remodeling in SHR.
Foulquier S, Lartaud I, Dupuis F.
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Growth hormone transgenesis and polyploidy increase metabolic rate, alter the cardiorespiratory response and influence HSP expression in response to acute hypoxia in Atlantic salmon (Salmo salar) yolk-sac alevins.
Polymeropoulos ET, Plouffe D, LeBlanc S, Elliott NG, Currie S, Frappell PB.
J Exp Biol. 2014 Jul 1;217(Pt 13):2268-76. doi: 10.1242/jeb.098913. Epub 2014 Mar 27.
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Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway
Bhattachariya, A., Dahan, D., Turczynska, K. M., Sward, K., Hellstrand, P. and Albinsson, S. Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway. (2014). Cardiovasc Res. 101 (2): 288-296.
The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles
Castorena-Gonzalez, J. A., Staiculescu, M. C., Foote, C. A., Polo-Parada, L. and Martinez-Lemus, L. A. The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles. (2014). Am J Physiol Heart Circ Physiol. 306 (4): H485-495.
Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation
Chrissobolis, S., Drummond, G. R., Faraci, F. M. and Sobey, C. G. Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. (2014). J Hypertens. 32 (9): 1815-1821.
Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-delta gene
d’Uscio, L. V., He, T., Santhanam, A. V., Tai, L. J., Evans, R. M. and Katusic, Z. S. Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-delta gene. (2014). Am J Physiol Heart Circ Physiol. 306 (7): H1001-1010.
A perfusion procedure for imaging of the mouse cerebral vasculature by X-ray micro-CT
Ghanavati, S., Yu, L. X., Lerch, J. P. and Sled, J. G. A perfusion procedure for imaging of the mouse cerebral vasculature by X-ray micro-CT. (2014). J Neurosci Methods. 221 70-77.
Pituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large-conductance Ca(2+)-activated (BK) and ATP-sensitive (K ATP) K (+) channels
Koide, M., Syed, A. U., Braas, K. M., May, V. and Wellman, G. C. Pituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large-conductance Ca(2+)-activated (BK) and ATP-sensitive (K ATP) K (+) channels. (2014). J Mol Neurosci. 54 (3): 443-450.
Involvement of H1 and H2 Receptors and Soluble Guanylate Cyclase in Histamine-Induced Relaxation of Rat Mesenteric Collecting Lymphatics
Kurtz K.H., Moor A.N., Souza-Smith F.M., Breslin J.W.
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Increasing muscle mass improves vascular function in obese (db/db) mice
Qiu, S., Mintz, J. D., Salet, C. D., Han, W., Giannis, A., Chen, F., Yu, Y., Su, Y., Fulton, D. J. and Stepp, D. W. Increasing muscle mass improves vascular function in obese (db/db) mice. (2014). J Am Heart Assoc. 3 (3): e000854.
Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure
Rickard, A. J., Morgan, J., Chrissobolis, S., Miller, A. A., Sobey, C. G. and Young, M. J. Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure. (2014). Hypertension. 63 (5): 1033-1040.
Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: a potential target for therapies
Rutkai, I., Katakam, P. V., Dutta, S. and Busija, D. W. Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: a potential target for therapies. (2014). Am J Physiol Heart Circ Physiol. 307 (7): H958-966.
Low K(+) current in arterial myocytes with impaired K(+)-vasodilation and its recovery by exercise in hypertensive rats
Seo, E. Y., Kim, H. J., Zhao, Z. H., Jang, J. H., Jin, C. Z., Yoo, H. Y., Zhang, Y. H. and Kim, S. J. Low K(+) current in arterial myocytes with impaired K(+)-vasodilation and its recovery by exercise in hypertensive rats. (2014). Pflugers Arch. 466 (11): 2101-2111.
Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function.
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Altered sensitivity to nitric oxide donors, induced by intravascular infusion of quantum dots, in murine mesenteric arteries
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Purinergic receptors regulate myogenic tone in cerebral parenchymal arterioles
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Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone
Brookes, Z. L., Ruff, L., Upadhyay, V. S., Huang, L., Prasad, S., Solanky, T., Nauli, S. M. and Ong, A. C. Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone. (2013). American Journal of Physiology-Heart and Circulatory Physiology. 304 (1): H33-H41.
Transcriptome Analysis for Notch3 Target Genes Identifies Grip2 as a Novel Regulator of Myogenic Response in the Cerebrovasculature
Fouillade, C., Baron-Menguy, C., Domenga-Denier, V., Thibault, C., Takamiya, K., Huganir, R. and Joutel, A. Transcriptome Analysis for Notch3 Target Genes Identifies Grip2 as a Novel Regulator of Myogenic Response in the Cerebrovasculature. (2013). Arteriosclerosis, Thrombosis, and Vascular Biology. 33 (1): 76-86.
Selective Involvement of Serum Response Factor in Pressure-Induced Myogenic Tone in Resistance Arteries
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Pregnancy causes diminished myogenic tone and outward hypotrophic remodeling of the cerebral vein of Galen
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Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice
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Phosphoinositide-Dependent Kinase-1 and Protein Kinase Cδ Contribute to Endothelin-1 Constriction and Elevated Blood Pressure in Intermittent Hypoxia
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Isolated small uterine arteries from non-pregnant and term pregnant rats exhibit regulatory responses to elevations in extravascular pressure
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Aortic stiffness and left atrial volume index in patients on continuous ambulatory peritoneal dialysis: Role of endothelial dysfunction
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Role of caveolae in shear stress-mediated endothelium-dependent dilation in coronary arteries
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Treatment for cerebral small vessel disease: effect of relaxin on the function and structure of cerebral parenchymal arterioles during hypertension
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Effect of pregnancy and nitric oxide on the myogenic vasodilation of posterior cerebral arteries and the lower limit of cerebral blood flow autoregulation
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Pressure-induced maturation of endothelial cells on newborn mouse carotid arteries
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Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca(2)(+)-activated K(+) channels and smooth muscle Ca(2)(+) sparks
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Mechanisms of acetylcholine-mediated vasodilation in systemic arteries from mourning doves (Zenaida macroura)
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Arginase promotes skeletal muscle arteriolar endothelial dysfunction in diabetic rats
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Reduced RhoA activity mediates acute alcohol intoxication-induced inhibition of lymphatic myogenic constriction despite increased cytosolic [Ca(2+) ]
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Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply?
Stapleton, P. A., Minarchick, V. C., Yi, J., Engels, K., McBride, C. R. and Nurkiewicz, T. R. Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply? (2013). Am J Obstet Gynecol. 209 (3): 227 e221-211.
Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes
Velmurugan, G. V., Sundaresan, N. R., Gupta, M. P. and White, C. Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes. (2013). Cardiovasc Res. 100 (1): 143-150.
Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide
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Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers
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Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage
Brizzio, M. E., Shaw, R. E., Bosticco, B., Collins, M., Grau, J. B., Mak, A. W. and Zapolanski, A. Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage. (2012). J Invasive Cardiol. 24 (2): 49-52.
TMEM16A Channels Contribute to the Myogenic Response in Cerebral Arteries
Bulley, S., Neeb, Z. P., Burris, S. K., Bannister, J. P., Thomas-Gatewood, C. M., Jangsangthong, W. and Jaggar, J. H. TMEM16A Channels Contribute to the Myogenic Response in Cerebral Arteries. (2012). Circulation Research. 111 (8): 1027-1036.
Lymphatic filariasis: Perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis
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Distinct endothelial pathways underlie sexual dimorphism in vascular autoregulation
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Poly (ADP-Ribose) Polymerase 1 Inhibition Improves Coronary Arteriole Function in Type 2 Diabetes Mellitus
Choi, S. K., Galan, M., Kassan, M., Partyka, M., Trebak, M. and Matrougui, K. Poly (ADP-Ribose) Polymerase 1 Inhibition Improves Coronary Arteriole Function in Type 2 Diabetes Mellitus. (2012). Hypertension. 59 (5): 1060-1068.
The effect of endothelin receptor A antagonism on basilar artery endothelium-dependent relaxation after ischemic stroke
Coucha, M., Li, W. and Ergul, A. The effect of endothelin receptor A antagonism on basilar artery endothelium-dependent relaxation after ischemic stroke. (2012). Life Sciences. 91 (13-14): 676-680.
Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels
Dabertrand, F., Nelson, M. T. and Brayden, J. E. Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels. (2012). Circulation research. 110 (2): 285-294.
Intrinsic increase in lymphangion muscle contractility in response to elevated afterload
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Impaired myogenic properties of cerebral arteries from the Brown Norway rat
Delaney, P. J., Burnham, M. P., Heagerty, A. M. and Izzard, A. S. Impaired myogenic properties of cerebral arteries from the Brown Norway rat. (2012). Journal of Hypertension. 30 (5): 926-931.
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis
Derwall, M., Malhotra, R., Lai, C. S., Beppu, Y., Aikawa, E., Seehra, J. S., Zapol, W. M., Bloch, K. D. and Yu, P. B. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. (2012). Arterioscler Thromb Vasc Biol. 32 (3): 613-622.
Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy
Detterich, J., Alexy, T., Rabai, M., Wenby, R., Dongelyan, A., Coates, T., Wood, J. and Meiselman, H. Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. (2012). Transfusion.
Renovascular hypertension impairs formation of endothelium‐derived relaxing factors and sensitivity to endothelin‐1 in resistance arteries
Dohi, Y., Criscione, L. and Lüscher, T. F. Renovascular hypertension impairs formation of endothelium‐derived relaxing factors and sensitivity to endothelin‐1 in resistance arteries. (2012). British journal of pharmacology. 104 (2): 349-354.
Adenovirus-mediated gene transfection in the isolated lymphatic vessels
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Regional heterogeneity of length-tension relationships in rat lymph vessels
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Propensity matched analysis of bilateral internal mammary artery versus single left internal mammary artery grafting at 17-year follow-up: validation of a contemporary surgical experience
Grau, J. B., Ferrari, G., Mak, A. W., Shaw, R. E., Brizzio, M. E., Mindich, B. P., Strobeck, J. and Zapolanski, A. Propensity matched analysis of bilateral internal mammary artery versus single left internal mammary artery grafting at 17-year follow-up: validation of a contemporary surgical experience. (2012). Eur J Cardiothorac Surg. 41 (4): 770-775; discussion 776.
Hemodynamic, Vascular, and Reproductive Impact of FMS-Like Tyrosine Kinase 1 (FLT1) Blockade on the Uteroplacental Circulation During Normal Mouse Pregnancy
Khankin, E. V., Mandala, M., Colton, I., Karumanchi, S. A. and Osol, G. Hemodynamic, Vascular, and Reproductive Impact of FMS-Like Tyrosine Kinase 1 (FLT1) Blockade on the Uteroplacental Circulation During Normal Mouse Pregnancy. (2012). Biology of reproduction. 86 (2): 57.
Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels
Koide, M., Bonev, A. D., Nelson, M. T. and Wellman, G. C. Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels. (2012). Proceedings of the National Academy of Sciences of the United States of America. 109 (21): E1387-1395.
Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells
Adebiyi, A., Narayanan, D. and Jaggar, J. H. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. (2011). The Journal of biological chemistry. 286 (6): 4341-4348.
Measuring contraction propagation and localizing pacemaker cells using high speed video microscopy
Akl, T. J., Nepiyushchikh, Z. V., Gashev, A. A., Zawieja, D. C. and Cot, G. L. Measuring contraction propagation and localizing pacemaker cells using high speed video microscopy. (2011). Journal of biomedical optics. 16 (2): 026016.
Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric oxide ratio
Barhoumi, T., Jallat, I., Berthelot, A. and Laurant, P. Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric oxide ratio. (2011). Canadian journal of physiology and pharmacology. 89 (6): 435-443.
Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes
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Increased myoendothelial gap junctions mediate the enhanced response to epoxyeicosatrienoic acid and acetylcholine in mesenteric arterial vessels of cirrhotic rats
Bolognesi, M., Zampieri, F., Di Pascoli, M., Verardo, A., Turato, C., Calabrese, F., Lunardi, F., Pontisso, P., Angeli, P., Merkel, C., Gatta, A. and Sacerdoti, D. Increased myoendothelial gap junctions mediate the enhanced response to epoxyeicosatrienoic acid and acetylcholine in mesenteric arterial vessels of cirrhotic rats. (2011). Liver international : official journal of the International Association for the Study of the Liver. 31 (6): 881-890.
Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide
Chadha, P. S., Liu, L., Rikard-Bell, M., Senadheera, S., Howitt, L., Bertrand, R. L., Grayson, T. H., Murphy, T. V. and Sandow, S. L. Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide. (2011). The Journal of pharmacology and experimental therapeutics. 336 (3): 701-708.
Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R
Chakraborty, S., Nepiyushchikh, Z., Davis, M. J., Zawieja, D. C. and Muthuchamy, M. Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R. (2011). Microcirculation. 18 (1): 24-35.
Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-{gamma}
Chan, S. L. and Cipolla, M. J. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-{gamma}. (2011). The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25 (9): 3229-3239.
Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles
Cherng, T. W., Paffett, M. L., Jackson-Weaver, O., Campen, M. J., Walker, B. R. and Kanagy, N. L. Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles. (2011). Environmental health perspectives. 119 (1): 98-103.
Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia
Cipolla, M. J., Sweet, J. G. and Chan, S. L. Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia. (2011). Journal of applied physiology. 110 (2): 329-339.
Rottlerin Increases Cardiac Contractile Performance and Coronary Perfusion Through BKCa++ Channel Activation After Cold Cardioplegic Arrest in Isolated Hearts
Clements, R. T., Cordeiro, B., Feng, J., Bianchi, C. and Sellke, F. W. Rottlerin Increases Cardiac Contractile Performance and Coronary Perfusion Through BKCa++ Channel Activation After Cold Cardioplegic Arrest in Isolated Hearts. (2011). Circulation. 124 (11 Suppl): S55-61.
p38 MAPK-dependent small HSP27 and alphaB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest
Clements, R. T., Feng, J., Cordeiro, B., Bianchi, C. and Sellke, F. W. p38 MAPK-dependent small HSP27 and alphaB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest. (2011). American journal of physiology. Heart and circulatory physiology. 300 (5): H1669-1677.
Relaxin regulates vascular wall remodeling and passive mechanical properties in mice
Debrah, D. O., Debrah, J. E., Haney, J. L., McGuane, J. T., Sacks, M. S., Conrad, K. P. and Shroff, S. G. Relaxin regulates vascular wall remodeling and passive mechanical properties in mice. (2011). Journal of applied physiology. 111 (1): 260-271.
Heme oxygenase regulates renal arterial resistance and sodium excretion in cirrhotic rats
Di Pascoli, M., Zampieri, F., Quarta, S., Sacerdoti, D., Merkel, C., Gatta, A. and Bolognesi, M. Heme oxygenase regulates renal arterial resistance and sodium excretion in cirrhotic rats. (2011). Journal of hepatology. 54 (2): 258-264.
Metoprolol impairs resistance artery function in mice
El Beheiry, M. H., Heximer, S. P., Voigtlaender-Bolz, J., Mazer, C. D., Connelly, K. A., Wilson, D. F., Beattie, W. S., Tsui, A. K., Zhang, H., Golam, K., Hu, T., Liu, E., Lidington, D., Bolz, S. S. and Hare, G. M. Metoprolol impairs resistance artery function in mice. (2011). Journal of applied physiology. 111 (4): 1125-1133.
Neuropeptide Y overflow and metabolism in skeletal muscle arterioles
Evanson, K. W., Stone, A. J., Hammond, A. L. and Kluess, H. A. Neuropeptide Y overflow and metabolism in skeletal muscle arterioles. (2011). The Journal of physiology. 589 (Pt 13): 3309-3318.
Resistance artery adaptation to pregnancy counteracts the vasoconstricting influence of plasma from normal pregnant women
Amburgey, O. A., Reeves, S. A., Bernstein, I. M. and Cipolla, M. J. Resistance artery adaptation to pregnancy counteracts the vasoconstricting influence of plasma from normal pregnant women. (2010). Reprod Sci. 17 (1): 29-39.
Deleterious combined effects of salt-loading and endothelial cell restricted endothelin-1 overexpression on blood pressure and vascular function in mice
Amiri, F., Ko, E. A., Javeshghani, D., Reudelhuber, T. L. and Schiffrin, E. L. Deleterious combined effects of salt-loading and endothelial cell restricted endothelin-1 overexpression on blood pressure and vascular function in mice. (2010). J Hypertens. 28 (6): 1243-1251.
Effects of pregnancy, hypertension and nitric oxide inhibition on rat uterine artery myogenic reactivity
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Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat
Behbahani, J., Thandapilly, S. J., Louis, X. L., Huang, Y., Shao, Z., Kopilas, M. A., Wojciechowski, P., Netticadan, T. and Anderson, H. D. Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat. (2010). Am J Hypertens. 23 (12): 1273-1278.
Migraine models
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Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA
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Lymphatic system: a vital link between metabolic syndrome and inflammation
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Effect of PPARgamma inhibition during pregnancy on posterior cerebral artery function and structure
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Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells
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A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation
Earley, S., Gonzales, A. L. and Garcia, Z. I. A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation. (2010). Molecular pharmacology. 77 (4): 612-620.
Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock
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Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteries
Lekontseva, O. N., Rueda-Clausen, C. F., Morton, J. S. and Davidge, S. T. Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteries. (2010). Menopause. 17 (3): 516-523.
Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring
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Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia
Miller, A. A., De Silva, T. M., Judkins, C. P., Diep, H., Drummond, G. R. and Sobey, C. G. Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. (2010). Stroke; a journal of cerebral circulation. 41 (4): 784-789.
Combinations of hydrostatic pressure and shear stress influence morphology and adhesion molecules in cultured endothelial cells
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Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat
Ochodnicky, P., Henning, R. H., Buikema, H. J., de Zeeuw, D., Provoost, A. P. and van Dokkum, R. P. Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat. (2010). American journal of physiology. Renal physiology. 298 (3): F625-633.