

Applying and maintaining physiological pressures in cannulated blood vessels is a key factor in vascular research. Precise control of pressure, with or without intraluminal flow, is a paramount necessity. Our pressure instrumentation is designed to establish, control, and measure the intraluminal pressure during an experiment.
Our vessel chambers are precision machined from inert plastic that has chemical and physical properties superior to acrylics, and is more economical than stainless steel.
Pressure arteriography is the gold-standard for quantifying function, reactivity and mechanics in isolated perfused blood vessels. When embarking on pressure arteriography, many factors warrant consideration. In addition to the requisite surgical skills for isolating and cannulating small arteries, proper instrumentation is also paramount. Pressure arteriography, while a powerful tool, comprises a number of different hardware and software components that must integrate and operate properly.
Living Systems Instrumentation is the only provider for complete pressure arteriography systems that not only allow the researcher to quickly get their experiments up and running, but ensures the quality and reproducibility of the data collected. Not only is LSI the pioneer in pressure arteriography, they also have a long and comprehensive publication history that speaks to their established and state-of-the-art arteriography systems.
While there are other options for individual arteriograph components available from various sources, these require significant investment in time to optimize, refine and “debug” that delays maintaining a regular experiment schedule and often lack the robustness required for data integrity and confidence.
And with their long experiential history and comprehensive knowledge base, Living Systems is always available to assist and support all of your arteriography needs.
As with any research protocol, the priority is to focus on your data, not your instruments. So if you are considering pressure arteriography, you can rely on the tried, tested and true systems offered by Living Systems Instrumentation to deliver accurate results in a timely and uncomplicated manner.
Constant Pressure
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Pressure Artiograph
Constant Pressure & Flow
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Sals includimall animng mice rats wire myograph myography
Parts of a Pressure Arteriograph
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The CH-1 is Living System’s most versatile chamber design, and is ideal for experiments requiring vessel diameter measurements. This chamber is well-suited for use in widefield and confocal fluorescence microscopy, or standard transmitted light microscopy, and allows visualization of blood vessels as small as 30 µm in diameter. Living System’s temperature controller (TC-09S) can be used to directly control or monitor bath temperature. For monitoring or controlling bath temperature, a bath thermistor sensor (THRS) is also required. Check out Living System’s self-heated single vessel chamber package (CH-1-SH) for self-heating temperature control applications.
Specifications Bath Volume: 3-8 ml |
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The CH-2 chamber is used to optimize experimental throughput, allowing two vessels to be mounted side by side. This chamber can be used for wide-field or confocal fluorescence microscopy, as well as standard transmitted light microscopy. The dual vessel chamber is ideal for bioassay work where perfusate from one vessel is routed to the adjacent vessel. It allows visualization of blood vessels as small as 30 µm in diameter. Living System’s temperature controller (TC-09D) can be used to directly control or monitor bath temperature. For monitoring or controlling bath temperature, a bath thermistor sensor (THRS) is also required for each of the two vessel baths. Check out Living System’s self-heated dual vessel chamber package (LS-CH-2-SH) for self-heating temperature control applications.
Key Features
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The CH-1-LIN Linear Alignment Vessel Chamber represents Living System’s latest design for their arteriograph line. Living System’s has incorporated three-axis (X-Y-Z) linear controls on both the proximal and distal cannulae arms. Cannulae can be easily aligned in three-dimensional space in just seconds using the simple thumb screws. No special tools are needed. The chamber is ideal for new users of pressure arteriographs, because alignment of the cannulae has been greatly simplified.
Key Features:
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Suitable for cannulation & perfusion of large hollow organs, such as blood vessels (e.g. aorta, carotid), intestine, airway, mid-gut, or colon. The unique size of this chamber also makes it suitable for other applications, such as insect mid-gut cannulation.
Key Features
Notes
Specifications Chamber Material: Delrin, stainless steel
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This chamber is designed for rapid freezing or fixation of a cannulated and pressurized vessel for biochemical or morphometric studies.
One section of the CH-1-QT contains the experimental chamber where a superfused vessel may be examined for its diameter responses to pharmacological agents, pressure, flow, etc. A glass coverslip allows visualization of the vessel for lumen diameter and wall measurements using the video dimension analyzer (VDA-10). The other section has a well that a removable tray fits into. A lever arm is used to quickly transfer (~1 sec) the vessel and its tubing connections from the chamber to the tray. In this way, the physiological state of the vessel (pressure, myogenic tone, etc) can be maintained during the freezing or fixation process. The CH-1-QT will readily tolerate the low temperature of an acetone-dry ice freezing solution, liquid nitrogen, or various fixing solutions. Specifications Bath Volume: 6-10ml |
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Liu X, Qian ZY, Xie F, Fan W, Nelson JW, Xiao X, Kaul S, Barnes AP, Alkayed NJ. Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid. Prostaglandins Other Lipid Mediat. 2016 Sep 17. pii: S1098-8823(16)30109-5. doi: 10.1016/j.prostaglandins.2016.09.002.
Microbial short chain fatty acid metabolites lower blood pressure via endothelial G-protein coupled receptor 41.
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Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation.
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Isolation and Cannulation of Cerebral Parenchymal Arterioles
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Traumatic brain injury causes endothelial dysfunction in the systemic microcirculation through arginase-1-dependent uncoupling of endothelial nitric oxide synthase
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Unpredictable Chronic Mild Stress Paradigm Established Effects of Pro- and Anti-inflammatory Cytokine on Neurodegeneration-Linked Depressive States in Hamsters with Brain Endothelial Damages
Avolio E, Fazzari G, Mele M, Alò R, Zizza M, Jiao W, Di Vito A, Barni T, Mandalà M, Canonaco M.
Mol Neurobiol. 2016 Oct 11. [Epub ahead of print] DOI: 10.1007/s12035-016-0171-1
The Beta-1-Receptor Blocker Nebivolol Elicits Dilation of Cerebral Arteries by Reducing Smooth Muscle [Ca2+]i.
Cseplo P, Vamos Z, Ivic I, Torok O, Toth A, Koller A.
PLoS One. 2016 Oct 7;11(10):e0164010. doi: 10.1371/journal.pone.0164010. eCollection 2016.
Human Placental Arterial Distensibility, Birth Weight, and Body Size Are Positively Related to Fetal Homocysteine Concentration.
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Reprod Sci. 2016 Nov 21. pii: 1933719116678694. [Epub ahead of print]
Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice.
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Intrauterine Growth Restriction Influences Vascular Remodeling and Stiffening in the Weanling Rat More than Sex or Diet.
Dodson RB, Miller TA, Powers KN, Yang Y, Yu B, Albertine KH, Zinkhan EK.
Am J Physiol Heart Circ Physiol. 2016 Nov 23:ajpheart.00610.2016. doi: 10.1152/ajpheart.00610.2016. [Epub ahead of print]
Altered hippocampal arteriole structure and function in a rat model of preeclampsia: Potential role in impaired seizure-induced hyperemia.
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J Cereb Blood Flow Metab. 2016 Nov 4. pii: 0271678X16676287. [Epub ahead of print]
Elevated K+ channel activity opposes vasoconstrictor response to serotonin (5-HT) in cerebral arteries of the Fawn Hooded Hypertensive rat.
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Physiol Genomics. 2016 Oct 27:physiolgenomics.00072.2016. doi: 10.1152/physiolgenomics.00072.2016. [Epub ahead of print]
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Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure
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PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats
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Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency
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Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency
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Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep
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Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction
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Mechanism of hydralazine-induced relaxation in resistance arteries during pregnancy: Hydralazine induces vasodilation via a prostacyclin pathway
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Perivascular Adipose Tissue: A Novel Regulator of Vascular Tone in the Rat Pregnancy
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Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat
Mazzuca, M. Q., Mata, K. M., Li, W., Rangan, S. S. and Khalil, R. A. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. (2015). J Pharmacol Exp Ther. 352 (2): 291-304.
Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes
Nieves-Cintron, M., Nystoriak, M. A., Prada, M. P., Johnson, K., Fayer, W., Dell’Acqua, M. L., Scott, J. D. and Navedo, M. F. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. (2015). J Biol Chem. 290 (12): 7918-7929.
Mechanisms of Acute Alcohol Intoxication-Induced Modulation of Cyclic Mobilization of [Ca(2+)] in Rat Mesenteric Lymphatic Vessels
Souza-Smith, F. M., Kerut, E. K., Breslin, J. W. and Molina, P. E. Mechanisms of Acute Alcohol Intoxication-Induced Modulation of Cyclic Mobilization of [Ca(2+)] in Rat Mesenteric Lymphatic Vessels. (2015). Lymphat Res Biol. 13 (2): 93-99.
GRK2 targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling
Tutunea-Fatan, E., Caetano, F. A., Gros, R. and Ferguson, S. S. GRK2 targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling. (2015). J Biol Chem. 290 (8): 5141-5155.
Impact of short-term treatment with telmisartan on cerebral arterial remodeling in SHR.
Foulquier S, Lartaud I, Dupuis F.
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Growth hormone transgenesis and polyploidy increase metabolic rate, alter the cardiorespiratory response and influence HSP expression in response to acute hypoxia in Atlantic salmon (Salmo salar) yolk-sac alevins.
Polymeropoulos ET, Plouffe D, LeBlanc S, Elliott NG, Currie S, Frappell PB.
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Products Used: Video Dimension Analyzer, PS-200 Pressure Servo Controller
Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway
Bhattachariya, A., Dahan, D., Turczynska, K. M., Sward, K., Hellstrand, P. and Albinsson, S. Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway. (2014). Cardiovasc Res. 101 (2): 288-296.
The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles
Castorena-Gonzalez, J. A., Staiculescu, M. C., Foote, C. A., Polo-Parada, L. and Martinez-Lemus, L. A. The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles. (2014). Am J Physiol Heart Circ Physiol. 306 (4): H485-495.
Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation
Chrissobolis, S., Drummond, G. R., Faraci, F. M. and Sobey, C. G. Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. (2014). J Hypertens. 32 (9): 1815-1821.
Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-delta gene
d’Uscio, L. V., He, T., Santhanam, A. V., Tai, L. J., Evans, R. M. and Katusic, Z. S. Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-delta gene. (2014). Am J Physiol Heart Circ Physiol. 306 (7): H1001-1010.
A perfusion procedure for imaging of the mouse cerebral vasculature by X-ray micro-CT
Ghanavati, S., Yu, L. X., Lerch, J. P. and Sled, J. G. A perfusion procedure for imaging of the mouse cerebral vasculature by X-ray micro-CT. (2014). J Neurosci Methods. 221 70-77.
Pituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large-conductance Ca(2+)-activated (BK) and ATP-sensitive (K ATP) K (+) channels
Koide, M., Syed, A. U., Braas, K. M., May, V. and Wellman, G. C. Pituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large-conductance Ca(2+)-activated (BK) and ATP-sensitive (K ATP) K (+) channels. (2014). J Mol Neurosci. 54 (3): 443-450.
Involvement of H1 and H2 Receptors and Soluble Guanylate Cyclase in Histamine-Induced Relaxation of Rat Mesenteric Collecting Lymphatics
Kurtz K.H., Moor A.N., Souza-Smith F.M., Breslin J.W.
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Increasing muscle mass improves vascular function in obese (db/db) mice
Qiu, S., Mintz, J. D., Salet, C. D., Han, W., Giannis, A., Chen, F., Yu, Y., Su, Y., Fulton, D. J. and Stepp, D. W. Increasing muscle mass improves vascular function in obese (db/db) mice. (2014). J Am Heart Assoc. 3 (3): e000854.
Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure
Rickard, A. J., Morgan, J., Chrissobolis, S., Miller, A. A., Sobey, C. G. and Young, M. J. Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure. (2014). Hypertension. 63 (5): 1033-1040.
Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: a potential target for therapies
Rutkai, I., Katakam, P. V., Dutta, S. and Busija, D. W. Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: a potential target for therapies. (2014). Am J Physiol Heart Circ Physiol. 307 (7): H958-966.
Low K(+) current in arterial myocytes with impaired K(+)-vasodilation and its recovery by exercise in hypertensive rats
Seo, E. Y., Kim, H. J., Zhao, Z. H., Jang, J. H., Jin, C. Z., Yoo, H. Y., Zhang, Y. H. and Kim, S. J. Low K(+) current in arterial myocytes with impaired K(+)-vasodilation and its recovery by exercise in hypertensive rats. (2014). Pflugers Arch. 466 (11): 2101-2111.
Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function.
Villalba N, Sonkusare SK, Longden TA, Tran TL, Sackheim AM, Nelson MT, Wellman GC, Freeman K.
J Am Heart Assoc. 2014 Dec;3(6):e001474. doi: 10.1161/JAHA.114.001474.
Altered sensitivity to nitric oxide donors, induced by intravascular infusion of quantum dots, in murine mesenteric arteries
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Purinergic receptors regulate myogenic tone in cerebral parenchymal arterioles
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Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone
Brookes, Z. L., Ruff, L., Upadhyay, V. S., Huang, L., Prasad, S., Solanky, T., Nauli, S. M. and Ong, A. C. Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone. (2013). American Journal of Physiology-Heart and Circulatory Physiology. 304 (1): H33-H41.
Transcriptome Analysis for Notch3 Target Genes Identifies Grip2 as a Novel Regulator of Myogenic Response in the Cerebrovasculature
Fouillade, C., Baron-Menguy, C., Domenga-Denier, V., Thibault, C., Takamiya, K., Huganir, R. and Joutel, A. Transcriptome Analysis for Notch3 Target Genes Identifies Grip2 as a Novel Regulator of Myogenic Response in the Cerebrovasculature. (2013). Arteriosclerosis, Thrombosis, and Vascular Biology. 33 (1): 76-86.
Selective Involvement of Serum Response Factor in Pressure-Induced Myogenic Tone in Resistance Arteries
Retailleau, K., Toutain, B., Galmiche, G., Fassot, C., Sharif-Naeini, R., Kauffenstein, G., Mericskay, M., Duprat, F., Grimaud, L., Merot, J., Lardeux, A., Pizard, A., Baudrie, V., Jeunemaitre, X., Feil, R., Gothert, J. R., Lacolley, P., Henrion, D., Li, Z. and Loufrani, L. Selective Involvement of Serum Response Factor in Pressure-Induced Myogenic Tone in Resistance Arteries. (2013). Arteriosclerosis, Thrombosis, and Vascular Biology. 33 (2): 339-346.
Pregnancy causes diminished myogenic tone and outward hypotrophic remodeling of the cerebral vein of Galen
van der Wijk, A. E., Schreurs, M. P. H. and Cipolla, M. J. Pregnancy causes diminished myogenic tone and outward hypotrophic remodeling of the cerebral vein of Galen. (2013). Journal of Cerebral Blood Flow & Metabolism. 23281424
Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice
Wan, E., Kushner, J. S., Zakharov, S., Nui, X., Chudasama, N., Kelly, C., Waase, M., Doshi, D., Liu, G. and Iwata, S. Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice. (2013). The FASEB Journal. 23325318
Phosphoinositide-Dependent Kinase-1 and Protein Kinase Cδ Contribute to Endothelin-1 Constriction and Elevated Blood Pressure in Intermittent Hypoxia
Webster, B. R., Osmond, J. M., Paredes, D. A., DeLeon, X. A., Jackson-Weaver, O., Walker, B. R. and Kanagy, N. L. Phosphoinositide-Dependent Kinase-1 and Protein Kinase Cδ Contribute to Endothelin-1 Constriction and Elevated Blood Pressure in Intermittent Hypoxia. (2013). Journal of Pharmacology and Experimental Therapeutics. 344 (1): 68-76.
Isolated small uterine arteries from non-pregnant and term pregnant rats exhibit regulatory responses to elevations in extravascular pressure
Withers, S., Taggart, M. and Austin, C. Isolated small uterine arteries from non-pregnant and term pregnant rats exhibit regulatory responses to elevations in extravascular pressure. (2013). Placenta. 34 (1): 82-84.
Aortic stiffness and left atrial volume index in patients on continuous ambulatory peritoneal dialysis: Role of endothelial dysfunction
Zapolski, T., Wysokinski, A., Ksiazek, A. and Jaroszynski, A. Aortic stiffness and left atrial volume index in patients on continuous ambulatory peritoneal dialysis: Role of endothelial dysfunction. (2013). Int J Cardiol. 162 (3): 253-256.
Role of caveolae in shear stress-mediated endothelium-dependent dilation in coronary arteries
Chai, Q., Wang, X. L., Zeldin, D. C. and Lee, H. C. Role of caveolae in shear stress-mediated endothelium-dependent dilation in coronary arteries. (2013). Cardiovasc Res. 100 (1): 151-159.
Treatment for cerebral small vessel disease: effect of relaxin on the function and structure of cerebral parenchymal arterioles during hypertension
Chan, S. L., Sweet, J. G. and Cipolla, M. J. Treatment for cerebral small vessel disease: effect of relaxin on the function and structure of cerebral parenchymal arterioles during hypertension. (2013). FASEB J. 27 (10): 3917-3927.
Effect of pregnancy and nitric oxide on the myogenic vasodilation of posterior cerebral arteries and the lower limit of cerebral blood flow autoregulation
Chapman, A. C., Cipolla, M. J. and Chan, S. L. Effect of pregnancy and nitric oxide on the myogenic vasodilation of posterior cerebral arteries and the lower limit of cerebral blood flow autoregulation. (2013). Reprod Sci. 20 (9): 1046-1054.
Pressure-induced maturation of endothelial cells on newborn mouse carotid arteries
Flavahan, S., Mozayan, M. M., Lindgren, I. and Flavahan, N. A. Pressure-induced maturation of endothelial cells on newborn mouse carotid arteries. (2013). Am J Physiol Heart Circ Physiol. 305 (3): H321-329.
Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca(2)(+)-activated K(+) channels and smooth muscle Ca(2)(+) sparks
Jackson-Weaver, O., Osmond, J. M., Riddle, M. A., Naik, J. S., Gonzalez Bosc, L. V., Walker, B. R. and Kanagy, N. L. Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca(2)(+)-activated K(+) channels and smooth muscle Ca(2)(+) sparks. (2013). Am J Physiol Heart Circ Physiol. 304 (11): H1446-1454.
Mechanisms of acetylcholine-mediated vasodilation in systemic arteries from mourning doves (Zenaida macroura)
Jarrett, C., Lekic, M., Smith, C. L., Pusec, C. M. and Sweazea, K. L. Mechanisms of acetylcholine-mediated vasodilation in systemic arteries from mourning doves (Zenaida macroura). (2013). J Comp Physiol B. 183 (7): 959-967.
Arginase promotes skeletal muscle arteriolar endothelial dysfunction in diabetic rats
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Reduced RhoA activity mediates acute alcohol intoxication-induced inhibition of lymphatic myogenic constriction despite increased cytosolic [Ca(2+) ]
Souza-Smith, F. M., Molina, P. E. and Breslin, J. W. Reduced RhoA activity mediates acute alcohol intoxication-induced inhibition of lymphatic myogenic constriction despite increased cytosolic [Ca(2+) ]. (2013). Microcirculation. 20 (5): 377-384.
Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply?
Stapleton, P. A., Minarchick, V. C., Yi, J., Engels, K., McBride, C. R. and Nurkiewicz, T. R. Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply? (2013). Am J Obstet Gynecol. 209 (3): 227 e221-211.
Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes
Velmurugan, G. V., Sundaresan, N. R., Gupta, M. P. and White, C. Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes. (2013). Cardiovasc Res. 100 (1): 143-150.
Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide
Baron, D. M., Yu, B., Lei, C., Bagchi, A., Beloiartsev, A., Stowell, C. P., Steinbicker, A. U., Malhotra, R., Bloch, K. D. and Zapol, W. M. Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide. (2012). Anesthesiology. 116 (3): 637-647.
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers
Berra, L., Coppadoro, A., Yu, B., Lei, C., Spagnolli, E., Steinbicker, A. U., Bloch, K. D., Lin, T., Sammy, F. Y., Warren, H. S., Fernandez, B. O., Feelisch, M., Dzik, W. H., Stowell, C. P. and Zapol, W. M. Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. (2012). Anesthesiology. 117 (1): 56-63.
Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage
Brizzio, M. E., Shaw, R. E., Bosticco, B., Collins, M., Grau, J. B., Mak, A. W. and Zapolanski, A. Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage. (2012). J Invasive Cardiol. 24 (2): 49-52.
TMEM16A Channels Contribute to the Myogenic Response in Cerebral Arteries
Bulley, S., Neeb, Z. P., Burris, S. K., Bannister, J. P., Thomas-Gatewood, C. M., Jangsangthong, W. and Jaggar, J. H. TMEM16A Channels Contribute to the Myogenic Response in Cerebral Arteries. (2012). Circulation Research. 111 (8): 1027-1036.
Lymphatic filariasis: Perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis
Chakraborty, S., Gurusamy, M., Zawieja, D. C. and Muthuchamy, M. Lymphatic filariasis: Perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis. (2012). Microcirculation. 23237232
Distinct endothelial pathways underlie sexual dimorphism in vascular autoregulation
Chan, M. V., Bubb, K. J., Noyce, A., Villar, I. C., Duchene, J., Hobbs, A. J., Scotland, R. S. and Ahluwalia, A. Distinct endothelial pathways underlie sexual dimorphism in vascular autoregulation. (2012). British Journal of Pharmacology. 167 (4): 805-817.
Poly (ADP-Ribose) Polymerase 1 Inhibition Improves Coronary Arteriole Function in Type 2 Diabetes Mellitus
Choi, S. K., Galan, M., Kassan, M., Partyka, M., Trebak, M. and Matrougui, K. Poly (ADP-Ribose) Polymerase 1 Inhibition Improves Coronary Arteriole Function in Type 2 Diabetes Mellitus. (2012). Hypertension. 59 (5): 1060-1068.
The effect of endothelin receptor A antagonism on basilar artery endothelium-dependent relaxation after ischemic stroke
Coucha, M., Li, W. and Ergul, A. The effect of endothelin receptor A antagonism on basilar artery endothelium-dependent relaxation after ischemic stroke. (2012). Life Sciences. 91 (13-14): 676-680.
Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels
Dabertrand, F., Nelson, M. T. and Brayden, J. E. Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels. (2012). Circulation research. 110 (2): 285-294.
Intrinsic increase in lymphangion muscle contractility in response to elevated afterload
Davis, M. J., Scallan, J. P., Wolpers, J. H., Muthuchamy, M., Gashev, A. A. and Zawieja, D. C. Intrinsic increase in lymphangion muscle contractility in response to elevated afterload. (2012). Am J Physiol Heart Circ Physiol. 303 (7): H795-808.
Impaired myogenic properties of cerebral arteries from the Brown Norway rat
Delaney, P. J., Burnham, M. P., Heagerty, A. M. and Izzard, A. S. Impaired myogenic properties of cerebral arteries from the Brown Norway rat. (2012). Journal of Hypertension. 30 (5): 926-931.
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis
Derwall, M., Malhotra, R., Lai, C. S., Beppu, Y., Aikawa, E., Seehra, J. S., Zapol, W. M., Bloch, K. D. and Yu, P. B. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. (2012). Arterioscler Thromb Vasc Biol. 32 (3): 613-622.
Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy
Detterich, J., Alexy, T., Rabai, M., Wenby, R., Dongelyan, A., Coates, T., Wood, J. and Meiselman, H. Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. (2012). Transfusion.
Renovascular hypertension impairs formation of endothelium‐derived relaxing factors and sensitivity to endothelin‐1 in resistance arteries
Dohi, Y., Criscione, L. and Lüscher, T. F. Renovascular hypertension impairs formation of endothelium‐derived relaxing factors and sensitivity to endothelin‐1 in resistance arteries. (2012). British journal of pharmacology. 104 (2): 349-354.
Adenovirus-mediated gene transfection in the isolated lymphatic vessels
Gashev, A. A., Li, J., Muthuchamy, M. and Zawieja, D. C.Adenovirus-mediated gene transfection in the isolated lymphatic vessels. (2012). 843 199-204.
Regional heterogeneity of length-tension relationships in rat lymph vessels
Gashev, A. A., Zhang, R. Z., Muthuchamy, M., Zawieja, D. C. and Davis, M. J. Regional heterogeneity of length-tension relationships in rat lymph vessels. (2012). Lymphat Res Biol. 10 (1): 14-19.
Propensity matched analysis of bilateral internal mammary artery versus single left internal mammary artery grafting at 17-year follow-up: validation of a contemporary surgical experience
Grau, J. B., Ferrari, G., Mak, A. W., Shaw, R. E., Brizzio, M. E., Mindich, B. P., Strobeck, J. and Zapolanski, A. Propensity matched analysis of bilateral internal mammary artery versus single left internal mammary artery grafting at 17-year follow-up: validation of a contemporary surgical experience. (2012). Eur J Cardiothorac Surg. 41 (4): 770-775; discussion 776.
Hemodynamic, Vascular, and Reproductive Impact of FMS-Like Tyrosine Kinase 1 (FLT1) Blockade on the Uteroplacental Circulation During Normal Mouse Pregnancy
Khankin, E. V., Mandala, M., Colton, I., Karumanchi, S. A. and Osol, G. Hemodynamic, Vascular, and Reproductive Impact of FMS-Like Tyrosine Kinase 1 (FLT1) Blockade on the Uteroplacental Circulation During Normal Mouse Pregnancy. (2012). Biology of reproduction. 86 (2): 57.
Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels
Koide, M., Bonev, A. D., Nelson, M. T. and Wellman, G. C. Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels. (2012). Proceedings of the National Academy of Sciences of the United States of America. 109 (21): E1387-1395.
Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells
Adebiyi, A., Narayanan, D. and Jaggar, J. H. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. (2011). The Journal of biological chemistry. 286 (6): 4341-4348.
Measuring contraction propagation and localizing pacemaker cells using high speed video microscopy
Akl, T. J., Nepiyushchikh, Z. V., Gashev, A. A., Zawieja, D. C. and Cot, G. L. Measuring contraction propagation and localizing pacemaker cells using high speed video microscopy. (2011). Journal of biomedical optics. 16 (2): 026016.
Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric oxide ratio
Barhoumi, T., Jallat, I., Berthelot, A. and Laurant, P. Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric oxide ratio. (2011). Canadian journal of physiology and pharmacology. 89 (6): 435-443.
Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes
Beleznai, T., Feher, A., Spielvogel, D., Lansman, S. L. and Bagi, Z. Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes. (2011). American journal of physiology. Heart and circulatory physiology. 300 (3): H777-783.
Increased myoendothelial gap junctions mediate the enhanced response to epoxyeicosatrienoic acid and acetylcholine in mesenteric arterial vessels of cirrhotic rats
Bolognesi, M., Zampieri, F., Di Pascoli, M., Verardo, A., Turato, C., Calabrese, F., Lunardi, F., Pontisso, P., Angeli, P., Merkel, C., Gatta, A. and Sacerdoti, D. Increased myoendothelial gap junctions mediate the enhanced response to epoxyeicosatrienoic acid and acetylcholine in mesenteric arterial vessels of cirrhotic rats. (2011). Liver international : official journal of the International Association for the Study of the Liver. 31 (6): 881-890.
Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide
Chadha, P. S., Liu, L., Rikard-Bell, M., Senadheera, S., Howitt, L., Bertrand, R. L., Grayson, T. H., Murphy, T. V. and Sandow, S. L. Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide. (2011). The Journal of pharmacology and experimental therapeutics. 336 (3): 701-708.
Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R
Chakraborty, S., Nepiyushchikh, Z., Davis, M. J., Zawieja, D. C. and Muthuchamy, M. Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R. (2011). Microcirculation. 18 (1): 24-35.
Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-{gamma}
Chan, S. L. and Cipolla, M. J. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-{gamma}. (2011). The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25 (9): 3229-3239.
Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles
Cherng, T. W., Paffett, M. L., Jackson-Weaver, O., Campen, M. J., Walker, B. R. and Kanagy, N. L. Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles. (2011). Environmental health perspectives. 119 (1): 98-103.
Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia
Cipolla, M. J., Sweet, J. G. and Chan, S. L. Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia. (2011). Journal of applied physiology. 110 (2): 329-339.
Rottlerin Increases Cardiac Contractile Performance and Coronary Perfusion Through BKCa++ Channel Activation After Cold Cardioplegic Arrest in Isolated Hearts
Clements, R. T., Cordeiro, B., Feng, J., Bianchi, C. and Sellke, F. W. Rottlerin Increases Cardiac Contractile Performance and Coronary Perfusion Through BKCa++ Channel Activation After Cold Cardioplegic Arrest in Isolated Hearts. (2011). Circulation. 124 (11 Suppl): S55-61.
p38 MAPK-dependent small HSP27 and alphaB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest
Clements, R. T., Feng, J., Cordeiro, B., Bianchi, C. and Sellke, F. W. p38 MAPK-dependent small HSP27 and alphaB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest. (2011). American journal of physiology. Heart and circulatory physiology. 300 (5): H1669-1677.
Relaxin regulates vascular wall remodeling and passive mechanical properties in mice
Debrah, D. O., Debrah, J. E., Haney, J. L., McGuane, J. T., Sacks, M. S., Conrad, K. P. and Shroff, S. G. Relaxin regulates vascular wall remodeling and passive mechanical properties in mice. (2011). Journal of applied physiology. 111 (1): 260-271.
Heme oxygenase regulates renal arterial resistance and sodium excretion in cirrhotic rats
Di Pascoli, M., Zampieri, F., Quarta, S., Sacerdoti, D., Merkel, C., Gatta, A. and Bolognesi, M. Heme oxygenase regulates renal arterial resistance and sodium excretion in cirrhotic rats. (2011). Journal of hepatology. 54 (2): 258-264.
Metoprolol impairs resistance artery function in mice
El Beheiry, M. H., Heximer, S. P., Voigtlaender-Bolz, J., Mazer, C. D., Connelly, K. A., Wilson, D. F., Beattie, W. S., Tsui, A. K., Zhang, H., Golam, K., Hu, T., Liu, E., Lidington, D., Bolz, S. S. and Hare, G. M. Metoprolol impairs resistance artery function in mice. (2011). Journal of applied physiology. 111 (4): 1125-1133.
Neuropeptide Y overflow and metabolism in skeletal muscle arterioles
Evanson, K. W., Stone, A. J., Hammond, A. L. and Kluess, H. A. Neuropeptide Y overflow and metabolism in skeletal muscle arterioles. (2011). The Journal of physiology. 589 (Pt 13): 3309-3318.
Resistance artery adaptation to pregnancy counteracts the vasoconstricting influence of plasma from normal pregnant women
Amburgey, O. A., Reeves, S. A., Bernstein, I. M. and Cipolla, M. J. Resistance artery adaptation to pregnancy counteracts the vasoconstricting influence of plasma from normal pregnant women. (2010). Reprod Sci. 17 (1): 29-39.
Deleterious combined effects of salt-loading and endothelial cell restricted endothelin-1 overexpression on blood pressure and vascular function in mice
Amiri, F., Ko, E. A., Javeshghani, D., Reudelhuber, T. L. and Schiffrin, E. L. Deleterious combined effects of salt-loading and endothelial cell restricted endothelin-1 overexpression on blood pressure and vascular function in mice. (2010). J Hypertens. 28 (6): 1243-1251.
Effects of pregnancy, hypertension and nitric oxide inhibition on rat uterine artery myogenic reactivity
Barron, C., Mandala, M. and Osol, G. Effects of pregnancy, hypertension and nitric oxide inhibition on rat uterine artery myogenic reactivity. (2010). Journal of vascular research. 47 (6): 463-471.
Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat
Behbahani, J., Thandapilly, S. J., Louis, X. L., Huang, Y., Shao, Z., Kopilas, M. A., Wojciechowski, P., Netticadan, T. and Anderson, H. D. Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat. (2010). Am J Hypertens. 23 (12): 1273-1278.
Migraine models
Benemei, S., De Cesaris, F., Nicoletti, P., Materazzi, S., Nassini, R. and Geppetti, P. Migraine models. (2010). Methods in molecular biology. 617 105-114.
Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA
Broughton, B. R., Jernigan, N. L., Norton, C. E., Walker, B. R. and Resta, T. C. Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA. (2010). American journal of physiology. Lung cellular and molecular physiology. 298 (2): L232-242.
Lymphatic system: a vital link between metabolic syndrome and inflammation
Chakraborty, S., Zawieja, S., Wang, W., Zawieja, D. C. and Muthuchamy, M. Lymphatic system: a vital link between metabolic syndrome and inflammation. (2010). Ann N Y Acad Sci. 1207 Suppl 1 E94-102.
Effect of PPARgamma inhibition during pregnancy on posterior cerebral artery function and structure
Chan, S. L., Chapman, A. C., Sweet, J. G., Gokina, N. I. and Cipolla, M. J. Effect of PPARgamma inhibition during pregnancy on posterior cerebral artery function and structure. (2010). Frontiers in physiology. 1 130.
Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells
Crnich, R., Amberg, G. C., Leo, M. D., Gonzales, A. L., Tamkun, M. M., Jaggar, J. H. and Earley, S. Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells. (2010). Am J Physiol Cell Physiol. 299 (3): C682-694.
A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation
Earley, S., Gonzales, A. L. and Garcia, Z. I. A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation. (2010). Molecular pharmacology. 77 (4): 612-620.
Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock
Johnson, R. A., Durante, W., Craig, T., Peyton, K. J., Myers, J. G., Stewart, R. M. and Johnson, F. K. Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock. (2010). The Journal of trauma. 69 (2): 384-391.
Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteries
Lekontseva, O. N., Rueda-Clausen, C. F., Morton, J. S. and Davidge, S. T. Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteries. (2010). Menopause. 17 (3): 516-523.
Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring
Mazzuca, M. Q., Wlodek, M. E., Dragomir, N. M., Parkington, H. C. and Tare, M. Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring. (2010). The Journal of physiology. 588 (Pt 11): 1997-2010.
Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia
Miller, A. A., De Silva, T. M., Judkins, C. P., Diep, H., Drummond, G. R. and Sobey, C. G. Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. (2010). Stroke; a journal of cerebral circulation. 41 (4): 784-789.
Combinations of hydrostatic pressure and shear stress influence morphology and adhesion molecules in cultured endothelial cells
Nakadate, H., Minamitani, H. and Aomura, S. Combinations of hydrostatic pressure and shear stress influence morphology and adhesion molecules in cultured endothelial cells. (2010). Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2010 3812-3815.
Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat
Ochodnicky, P., Henning, R. H., Buikema, H. J., de Zeeuw, D., Provoost, A. P. and van Dokkum, R. P. Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat. (2010). American journal of physiology. Renal physiology. 298 (3): F625-633.