The survival of tissues and organs relies on an adequate supply of oxygen which is distributed together with nutrients and signal molecules via microvascular blood perfusion. Tissue oxygen tension (ptiO2) is a readout of oxygen availability at the cellular level representing the balance between oxygen supply and metabolic oxygen consumption. in addition, the measurement of microvascular blood perfusion provides critical information for research applications where blood supply has been disrupted. Combining these measurements gives the researcher a very powerful and unique tool to answer questions in the areas of physiology, oncology, cerebral monitoring, ischemia/reperfusion, ophthalmology and many more.
During this webinar, sponsored by Scintica Instrumentation, Professor Clive May and Dr. Yugeesh Lankadeva, from the Florey Institute of Neuroscience and Mental Health in Melbourne, discuss their research investigating the causes of acute renal failure in large animal models, the effects of resuscitation with volume or vasopressor drugs on renal perfusion and oxygenation in sepsis, and the measurement of bladder urinary pO2 as a real-time estimate of renal medullary ptiO2.
First, they will present the development and validation of methodology to measure renal cortical and medullary tissue perfusion and oxygenation long-term in conscious animals. Specifically, they will review selective changes in renal cortical and medullary tissue perfusion and oxygenation in response to alterations in total organ blood flow and administration of drugs.
In addition, Professor May and Dr. Lankadeva will share data from their studies demonstrating changes in total renal blood flow, renal function and differential changes in renal cortical and medullary perfusion, and pO2 during resuscitation and in models of sepsis. They will conclude the presentation with a focus on why the study of septic acute kidney injury is so important.