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Physiology

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New Journal Article – Cell Proliferation Detected Using [18F]FLT PET/CT as an Early Marker of Abdominal Aortic Aaneurysm

Abdominal aortic aneurysm (AAA) is a localized dilatation of the abdominal aorta which shows limited symptomology prior to rupture. Once rupture occurs though, the results may be catastrophic leading to intense pain, loss of consciousness, and possibly death. Detection often occurs incidentally or through routine screening, and surgical intervention is generally limited to large

By |2020-06-26T14:20:38-04:00June 26th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: , |Comments Off on New Journal Article – Cell Proliferation Detected Using [18F]FLT PET/CT as an Early Marker of Abdominal Aortic Aaneurysm

(July 14, 2020) WEBINAR: Vascular Aging – New Lessons From a Novel “Knock-In” Mouse Model

Zoom Registration Form Below July 14, 2020 11:00 AM - 12:00 PM (EDT) (UTC−04:00) In this webinar Dr. Lakshmi Santhanam an associate professor of Anesthesiology and Critical Care Medicine and Biomedical Engineering at the Johns Hopkins University School of Medicine will discuss her most recent work in vascular aging. Dr.

By |2020-06-16T12:43:05-04:00June 9th, 2020|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Event, Fish, Webinar|Tags: |Comments Off on (July 14, 2020) WEBINAR: Vascular Aging – New Lessons From a Novel “Knock-In” Mouse Model

(June 10, 2020) WEBINAR: Aging and the Cardiovascular System; An in vivo and in vitro approach to the pre-clinical assessment of arterial stiffness

Almost one third of deaths world-wide can be attributed to cardiovascular diseases (CVD). More than half of those cases are related to systemic arterial hypertension (SAH). There are several risk factors that contribute to the development of SAH. Type II diabetes causes structural and functional damage to arterial walls, which leads to stiffness

By |2020-06-24T09:54:47-04:00May 29th, 2020|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Event, Mouse, Physiology, Rat, Webinar|Tags: , |Comments Off on (June 10, 2020) WEBINAR: Aging and the Cardiovascular System; An in vivo and in vitro approach to the pre-clinical assessment of arterial stiffness

(June 3, 2020) Webinar: The Importance of Oxygenation in Tissue; an in vivo Approach in Animal Models

The survival of tissues and organs relies on an adequate supply of oxygen. Tissue oxygen tension (ptiO2) provides a direct measurement of the balance between oxygen supply (by the blood) and metabolic oxygen consumption (by the tissue), i.e. a readout of oxygen availability at the cellular level. On Demand

By |2020-06-03T16:30:01-04:00May 27th, 2020|Categories: Cancer Research, Event, Hypoxia, Molecular, Tissue Oxygen, Webinar|Tags: |Comments Off on (June 3, 2020) Webinar: The Importance of Oxygenation in Tissue; an in vivo Approach in Animal Models

WEBINAR: Cardiac Fibrosis – A Comprehensive Overview of Mechanisms, Tools and Potential Targets

This free webinar hosted by Scintica Instrumentation looked at the following: 1) Fibrosis– general introduction, 2) signaling pathways regulating cardiac fibrosis, 3) potential targets of cardiac fibrosis 4) techniques to measure cardiac fibrosis including using Doppler Flow Velocity measurements Slide Deck On Demand Q & A

By |2020-06-12T14:31:57-04:00May 25th, 2020|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Event, Mouse, Physiology, Rat, Webinar|Tags: , , , |Comments Off on WEBINAR: Cardiac Fibrosis – A Comprehensive Overview of Mechanisms, Tools and Potential Targets

New Journal Article – Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

Circadian Rhythms lead to the coordination of a multitude of physiological, behavioural, and metabolic processes to the natural 24-hour periodicity of the earth’s rotation. In this paper from 2019 published in Molecular Metabolism, researchers demonstrated the important of an overall synchronized circadian clock network to maintain metabolic homeostasis. In mammals, many metabolic processes are

By |2020-06-03T12:56:00-04:00April 27th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: |Comments Off on New Journal Article – Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

New Journal Article – Ultrasound-Induced Microbubble Cavitation via a Transcanal or Transcranial Approach Facilitates Inner Ear Drug Delivery

In a recent paper published in JCI Insight, researchers have demonstrated for the first time the feasibility of applying Ultrasound-induced Microbubble Cavitation via the external auditory canal as a technique to increase the efficiency of drug delivery to the inner ear. Effective treatment of auditory diseases, such as hearing loss and tinnitus, has become

By |2020-06-03T12:56:42-04:00March 23rd, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: |Comments Off on New Journal Article – Ultrasound-Induced Microbubble Cavitation via a Transcanal or Transcranial Approach Facilitates Inner Ear Drug Delivery

New Journal Article – Development of a Novel Superparamagnetic Nanoparticles to Quantify Nerve Density in Prostate Cancer and for Targeted Drug Delivery in the Same Model

In this journal article published in early February 2020 titled “Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer” in Science Advances, Huijuan You et al. discuss the development of their novel superparamagnetic iron oxide nerve peptide nanoparticles (PSN NPs) to image and quantify nerve density in a mouse

By |2020-06-03T13:01:32-04:00February 25th, 2020|Categories: Animal Models, Articles, Mouse, Rat, Telemetry, Tissue Oxygen|Tags: , |Comments Off on New Journal Article – Development of a Novel Superparamagnetic Nanoparticles to Quantify Nerve Density in Prostate Cancer and for Targeted Drug Delivery in the Same Model

WEBINAR: Utilizing Doppler Flow to Investigate the Hemodynamic Effects of Anti-Cancer Therapies

Recent advances in targeted cancer therapies has led to the development of a number of novel approaches that have demonstrated some clinical advantages in terms of prolonging overall survival and progression free survival. One of these approaches involves inhibiting angiogenesis (the growth of blood vessels from a pre-existing vasculature), using therapies that

By |2020-05-22T15:42:32-04:00January 6th, 2020|Categories: Animal Models, Cancer Research, Cardiovascular Research, Event, Mouse, Physiology, Rat, Telemetry, Upcoming, Webinar|Tags: |Comments Off on WEBINAR: Utilizing Doppler Flow to Investigate the Hemodynamic Effects of Anti-Cancer Therapies

Experimental Biology – April 5 – 7, 2020 – San Diego, CA

Scintica Instrumentation will be attending EB (Experimental Biology) Annual Meeting 2020. We will be at booth 1509 and will have on display: High Frequency 3D Ultrasound Compact MRI with optional PET insert Doppler Flow Velocity System Telemetry for Small Animals Small Vessel Myograph Systems Blood and Oxygen Tissue Monitors Stop by and chat

By |2020-05-22T15:42:40-04:00December 17th, 2019|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Conference, Event, Fish, Imaging, Micro-Vascular Flow, Mouse, MRI, Physiology, Rat, Telemetry, Tissue Oxygen, Ultrasound, Upcoming|Comments Off on Experimental Biology – April 5 – 7, 2020 – San Diego, CA