Would you like to have access to an IVM System at your facility?

IVM is an all-in-one confocal/two-photon microscopy system designed and optimized for imaging live animal models.

 

IVIM Tech

The IVM line of intravital microscopy systems have been specifically designed for longitudinal, in vivo, imaging on small animals. This all-in-one system includes an enclosed system, simplifying the citing of this instrument, as a dark room is not required. Additionally the IVM systems include physiological monitoring and support to ensure the welfare of the imaging subject. Various models are available, allowing for confocal and/or two photon imaging capabilities.

Do not miss the chance to see how the IVIM Tech System can help you hone your research.

Request Your Software DEMO at WMIC 2022! 

IVIM Application Information

Presentations at WMIC 2022

Publications

Bone Marrow

Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclearcytoplasmic labeling

Cranial Imaging

Delivery of Periodontopathogenic Extracellular Vesicles to Brain Monocytes and Microglial IL-6 Promotion by RNA Cargo

A Novel Pancreatic Imaging Window

A Novel Pancreatic Imaging Window for Stabilized Longitudinal In Vivo Observation of Pancreatic Islets in Murine Model

Caspase-8

Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells

Periodontopathogenic

Delivery of Periodontopathogenic Extracellular Vesicles to Brain Monocytes and Microglial IL-6 Promotion by RNA Cargo

Exosome-based delivery

Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality

In vivo cellular-level

In vivo cellular-level real-time pharmacokinetic imaging of free-form and liposomal indocyanine green in liver

Kidney Ischemia-reperfusion Injury

Exosome-based delivery of super-repressor IkBa ameliorates kidney ischemia-reperfusion injury

– J. Ahn, et. al., Biomed. Optics Express, 10(6):2719 (2019)

– D.Y.Kim, et. al., Scientific Reports, 9:3560 (2019)

– J. Ahn, et. al., Biomed. Optics Express, 6(10):3963 (2015)

– K. Jung, et. al., Circulation Res., 112(6):891 (2013)

– J. K. Kim, et. al., Nature Protocols, 7(8): 1456 (2012)

– P. Kim, et. al., Nature Methods, 7(4):303 (2010)

– Z. Fan, et. al., Nature Medicine, 16(6):718 (2010)

Lung

 – I. Park, et. al., European Respiratory Journal, 53:1800736 (2019)

 – I. Park, et. al., Biomedical Optics Express, 9(5):2383-2393 (2018)

 – S. Han, et. al., Science Translational Medicine, 8(335):335ra55 (2016)

Liver

– J. Moon, et. al., Biomed. Optics Express, 11(9):5132-5146 (2020)

– B. Oh, et. al., Diabetes, 67(3):473-485 (2018)

– Y. Hwang, et. al., Biomed. Optics Express, 8(10):4706-4716 (2017)
– A. L. van de Ven, et. al., Journal of Controlled Release, 158(1):148 (2012)

Small Intestine

 – K. Choe, et. al., Journal of Clinical Investigation, 125(11) :4042 (2015)

 – J. Ahn, et. al., Biomedical Optics Express, 6(10):3963-3972 (2015)

Colon

 – J. W. Choi, P. Kim, et. al., Theranostics, 5(7):724-732 (2015)

 – J. K. Kim, W. M. Lee, et. al., Nature Protocols, 7(8): 1456-1469 (2012)

 – P. Kim, E. Chung, et. al., Nature Methods, 7(4):303-305 (2010)

Heart

 – K. Jung, P. Kim, et. al., Circulation Research, 112(6):891-899 (2013)

Brain

 – J. Lee, et. al., Biomed. Optics Express, 11(8):4835-4847 (2020)

Bone Marrow

 – S. Ahn, et. al., PLos ONE, 12(11):e0187660 (2017)

Pancreas

 – I. Park, et. al., Diabetes & Metabolism Journal, 44:193-198 (2020)

Spleen

 – H. Choi, et. al., Science Advances, 6(15):eaa6980 (2020)

Prostate

 – S. K. Ghosh, et. al., Cancer Research, 70(15):6119-6127 (2010)

Kidney

 – E.M. Lee, et. al., Islets, 10(1):25-39 (2018)

 – Z. Fan, et. al., Nature Medicine, 16(6):718-722 (2010)

Thyroid gland

 – J. Y. Jang, et. al., EMBO Molecular Medicine, 9:750 (2017)

Mesentery

-K. Kim, et. al., Scientific Report, 6:33804 (2016)

Lymph Node

 – K. Choe, et. al., Journal of Biomedical Optics, 18(3):036005 (2013)

 – L. Zhi, P. Kim, et. al., Journal of Immunology, 187(5):2244-2251 (2011)

Eye / Retina

 – J. Kim, et. al. Science Advances, 5(2):eaau6732 (2019)

 – S. Ogura, et. al., JCI Insight, 2(3):e90905 (2017)

 – J. Y. Lee, et. al., Invest. Ophthalmology & Visual Sci., 57(7):3390 (2016)

 – J. R. Park, et. al., Invest. Ophthalmology & Visual Sci., 57:OCT331 (2016)

 – D-Y. Park, J. Lee, et. al., Journal of Clinical Investigation, 124(9):3960 (2014)

Skin

 – J. Ahn, et. al. Biomedical Optics Express, 9(8):3974-3982 (2018)

 – J.Y. Kim, et. al., ACS Nano, 12(7):6904-6916 (2018)
 – S. B. Kim, et. al., J. Cell Biology, 216(7):2201 (2017)

 – Y. Hwang, J. Ahn, et. al., Optics Express, 22(10):11465-11475 (2014)

 – J. Y. Lee, C. Park, et. al., Circulation, 122(14):1413-1425 (2010)

 – X. Chen, P. Kim, et. al., PLoS ONE, 5, e13776. doi:10.1371 (2010)

Tumor Model

 – J. Xu, et. al., Small, 14(50):1803601 (2018)

Circulating Tumor Cell

 – J. W. Choi, et. al, Cancer Research, 75(21):4474-4482 (2015)

 – H. Seo, et.al., Biomedical Optics Express, 6(6):2158-2167 (2015)

 – D. Lee, et. al., Hepatology, 61(6):1978-1997 (2015)

Microcirculation / Blood Cell Flow

– I. Park, et. al., European Respiratory Journal, 53:1800736 (2019)

– I. Park, et. al., Biomedical Optics Express, 9(5):2383-2393 (2018)

– Y. Hwang, et. al., Biomed. Optics Express, 8(10):4706 (2017)

– J. Y. Jang, et. al., EMBO Molecular Medicine, 9:750 (2017)

– S. Han, et. al., Science Translational Medicine, 8(335):335ra55 (2016)

– K. Kim, et. al., Scientific Report, 6:33804 (2016)

– K. Choe, et. al., Journal of Clinical Investigation, 125(11) :4042 (2015)

– H. Seo, et.al., Biomed. Optics Express, 6(6):2158 (2015)

– J. W. Choi, et. al, Cancer Research, 75(21):4474 (2015)

– J. Ahn, et. al., Biomed. Optics Express, 6(10):3963 (2015)

– A. L. van de Ven, et. al., J. of Controlled Release,   158(1):148 (2012)

Drug Delivery / Efficacy Monitoring

– H. Choi, et. al., Science Advances, 6(15):eaa6980 (2020)

– I. Park, et. al., European Respiratory Journal, 53:1800736 (2019)

– J. Xu, et. al., Small, 14(50):1803601 (2018)

– J.Y. Kim, et. al., ACS Nano, 12(7):6904-6916 (2018)
– J. Ahn, et. al. Biomedical Optics Express, 9(8):3974-3982 (2018)

– K. Choe, et. al., Journal of Clinical Investigation, 125(11) :4042 (2015)

– A. L. van de Ven, et. al., J. of Controlled Release,   158(1):148 (2012)
Cell Delivery / Transplantation

– B. Oh, et. al., Diabetes, 67(3):473-485 (2018)

– E.M. Lee, et. al., Islets, 10(1):25-39 (2018)

– Z. Fan, et. al., Nature Medicine, 16(6):718-722 (2010)

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