Would you like to have access to an IVM System at your facility?

IVM is an all-in-one confocal/two-photon microscopy system designed and optimized for imaging live animal models.

 The platform is designed to overcome existing challenges associated with conducting in vivo longitudinal studies using conventional confocal and two-photon systems which are suitable for endpoint histological analysis on sectioned tissues. 

Animal maintenance platform, motion compensation function, and ultra-fast frame rate allow the acquisition of high-resolution images of all tissues and organs in the body. Monitoring the dynamics of biological phenomena at cellular and subcellular resolution in vivo and overtime is a next-generation core technology to unravel biology in healthy and diseased states. 

 

Do not miss the chance to see how the IVIM Tech System can help you hone your research.

Apply today to qualify for this great opportunity.

Use the demo system in your lab for 6 months!

IVIM Application Information

Publications

Bone Marrow

Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclearcytoplasmic labeling

Cranial Imaging

Delivery of Periodontopathogenic Extracellular Vesicles to Brain Monocytes and Microglial IL-6 Promotion by RNA Cargo

Fatty Liver Disease

Intravital longitudinal imaging of hepatic lipid droplet accumulation in a murine model for nonalcoholic fatty liver disease

Kidney Ischemia-reperfusion Injury

Exosome-based delivery of super-repressor IkBa ameliorates kidney ischemia-reperfusion injury

– J. Ahn, et. al., Biomed. Optics Express, 10(6):2719 (2019)

– D.Y.Kim, et. al., Scientific Reports, 9:3560 (2019)

– J. Ahn, et. al., Biomed. Optics Express, 6(10):3963 (2015)

– K. Jung, et. al., Circulation Res., 112(6):891 (2013)

– J. K. Kim, et. al., Nature Protocols, 7(8): 1456 (2012)

– P. Kim, et. al., Nature Methods, 7(4):303 (2010)

– Z. Fan, et. al., Nature Medicine, 16(6):718 (2010)

Lung

 – I. Park, et. al., European Respiratory Journal, 53:1800736 (2019)

 – I. Park, et. al., Biomedical Optics Express, 9(5):2383-2393 (2018)

 – S. Han, et. al., Science Translational Medicine, 8(335):335ra55 (2016)

Liver

– J. Moon, et. al., Biomed. Optics Express, 11(9):5132-5146 (2020)

– B. Oh, et. al., Diabetes, 67(3):473-485 (2018)

– Y. Hwang, et. al., Biomed. Optics Express, 8(10):4706-4716 (2017)
– A. L. van de Ven, et. al., Journal of Controlled Release, 158(1):148 (2012)

Small Intestine

 – K. Choe, et. al., Journal of Clinical Investigation, 125(11) :4042 (2015)

 – J. Ahn, et. al., Biomedical Optics Express, 6(10):3963-3972 (2015)

Colon

 – J. W. Choi, P. Kim, et. al., Theranostics, 5(7):724-732 (2015)

 – J. K. Kim, W. M. Lee, et. al., Nature Protocols, 7(8): 1456-1469 (2012)

 – P. Kim, E. Chung, et. al., Nature Methods, 7(4):303-305 (2010)

Heart

 – K. Jung, P. Kim, et. al., Circulation Research, 112(6):891-899 (2013)

Brain

 – J. Lee, et. al., Biomed. Optics Express, 11(8):4835-4847 (2020)

Bone Marrow

 – S. Ahn, et. al., PLos ONE, 12(11):e0187660 (2017)

Pancreas

 – I. Park, et. al., Diabetes & Metabolism Journal, 44:193-198 (2020)

Spleen

 – H. Choi, et. al., Science Advances, 6(15):eaa6980 (2020)

Prostate

 – S. K. Ghosh, et. al., Cancer Research, 70(15):6119-6127 (2010)

Kidney

 – E.M. Lee, et. al., Islets, 10(1):25-39 (2018)

 – Z. Fan, et. al., Nature Medicine, 16(6):718-722 (2010)

Thyroid gland

 – J. Y. Jang, et. al., EMBO Molecular Medicine, 9:750 (2017)

Mesentery

-K. Kim, et. al., Scientific Report, 6:33804 (2016)

Lymph Node

 – K. Choe, et. al., Journal of Biomedical Optics, 18(3):036005 (2013)

 – L. Zhi, P. Kim, et. al., Journal of Immunology, 187(5):2244-2251 (2011)

Eye / Retina

 – J. Kim, et. al. Science Advances, 5(2):eaau6732 (2019)

 – S. Ogura, et. al., JCI Insight, 2(3):e90905 (2017)

 – J. Y. Lee, et. al., Invest. Ophthalmology & Visual Sci., 57(7):3390 (2016)

 – J. R. Park, et. al., Invest. Ophthalmology & Visual Sci., 57:OCT331 (2016)

 – D-Y. Park, J. Lee, et. al., Journal of Clinical Investigation, 124(9):3960 (2014)

Skin

 – J. Ahn, et. al. Biomedical Optics Express, 9(8):3974-3982 (2018)

 – J.Y. Kim, et. al., ACS Nano, 12(7):6904-6916 (2018)
 – S. B. Kim, et. al., J. Cell Biology, 216(7):2201 (2017)

 – Y. Hwang, J. Ahn, et. al., Optics Express, 22(10):11465-11475 (2014)

 – J. Y. Lee, C. Park, et. al., Circulation, 122(14):1413-1425 (2010)

 – X. Chen, P. Kim, et. al., PLoS ONE, 5, e13776. doi:10.1371 (2010)

Tumor Model

 – J. Xu, et. al., Small, 14(50):1803601 (2018)

Circulating Tumor Cell

 – J. W. Choi, et. al, Cancer Research, 75(21):4474-4482 (2015)

 – H. Seo, et.al., Biomedical Optics Express, 6(6):2158-2167 (2015)

 – D. Lee, et. al., Hepatology, 61(6):1978-1997 (2015)

Microcirculation / Blood Cell Flow

– I. Park, et. al., European Respiratory Journal, 53:1800736 (2019)

– I. Park, et. al., Biomedical Optics Express, 9(5):2383-2393 (2018)

– Y. Hwang, et. al., Biomed. Optics Express, 8(10):4706 (2017)

– J. Y. Jang, et. al., EMBO Molecular Medicine, 9:750 (2017)

– S. Han, et. al., Science Translational Medicine, 8(335):335ra55 (2016)

– K. Kim, et. al., Scientific Report, 6:33804 (2016)

– K. Choe, et. al., Journal of Clinical Investigation, 125(11) :4042 (2015)

– H. Seo, et.al., Biomed. Optics Express, 6(6):2158 (2015)

– J. W. Choi, et. al, Cancer Research, 75(21):4474 (2015)

– J. Ahn, et. al., Biomed. Optics Express, 6(10):3963 (2015)

– A. L. van de Ven, et. al., J. of Controlled Release,   158(1):148 (2012)

Drug Delivery / Efficacy Monitoring

– H. Choi, et. al., Science Advances, 6(15):eaa6980 (2020)

– I. Park, et. al., European Respiratory Journal, 53:1800736 (2019)

– J. Xu, et. al., Small, 14(50):1803601 (2018)

– J.Y. Kim, et. al., ACS Nano, 12(7):6904-6916 (2018)
– J. Ahn, et. al. Biomedical Optics Express, 9(8):3974-3982 (2018)

– K. Choe, et. al., Journal of Clinical Investigation, 125(11) :4042 (2015)

– A. L. van de Ven, et. al., J. of Controlled Release,   158(1):148 (2012)
Cell Delivery / Transplantation

– B. Oh, et. al., Diabetes, 67(3):473-485 (2018)

– E.M. Lee, et. al., Islets, 10(1):25-39 (2018)

– Z. Fan, et. al., Nature Medicine, 16(6):718-722 (2010)

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