Zebrafish (Danio rerio) models are increasing in popularity, given several characteristics that make them suitable for genetic and disease research. These small, inexpensive fish produce hundreds of offspring, exhibit rapid growth, and have a similar genetic structure to humans. Their nearly transparent bodies make it possible to observe development and vasculature with simple microscopes. We offer solutions for cardiovascular research in zebrafish models.
Zebrafish Cardiac Function
Adult zebrafish (Danio rerio) are used to study cardiac development and tissue regeneration. The Doppler Flow Velocity System enables non-invasive assessment of cardiac function using blood flow velocity measurements. The fish are anesthetized and stabilized on a sponge, and the small, non-invasive probe is placed on the surface of the body to detect flow velocity waveforms.
Ultrasound imaging is a non-invasive way to visualize a number of anatomical structures and disease processes in fish mainly for cardiovascular research and cancer biology. Image guided needle injection and 3D imaging are all possible using this system.
The CardioFish system is especially useful for pharmacology and toxicology research. ECG signals can be recorded for later analysis, for example QT analysis and heart rate variability. The system can be configured with a cannula connection for drug injection into the surrounding liquid, or an external drug injection port for injection directly into tissues.