(August 18, 2020) WEBINAR: Inflammation and the Resolution of Inflammation in Heart Failure: Preclinical and Clinical Findings
This webinar hosted by Scintica Instrumentation looked primarily at inflammation and the resolution of inflammation in the preclinical mouse model. Physiological short-term inflammation is a primary signal of the immune system activation that is an important defense system of the body. If inflammation remains activated for an extended period of time, in the presence or absence of injury due to risk factors, it will lead to a pathological response. Response to cardiac injury inflammation is widely studied, however the resolution of inflammation (safe clearance of inflammation) is understudied. In the majority of cases, the outcome of inflammation blockade is less encouraging and sometimes fatal to cardiac health.
Dr. Ganesh Halade, Associate Professor of Medicine at the University of South Florida in Tampa, Florida, discussed the resolution of inflammation in cardiac repair with a major focus on bioactive lipid mediators in preclinical studies and confirmation of these molecules in patients following myocardial infarction. He considered the most common risk factors such as obesity and aging as primary causes of the unresolved inflammation following myocardial infarction.
During Dr. Halade’s presentation, he provided examples of functional data using high resolution ultrasound echocardiography, quantification of bioactive lipid species using mass spectrometry, histological data, and also provided a brief introduction to confirming permanent coronary ligation by monitoring ECG waveforms, specifically ST segment elevation.
Key questions addressed during this webinar will include:
What is the role of inflammation in cardiac repair?
What are the bioactive signature molecules of inflammation and resolution?
How is inflammation dysregulated leading to unresolved inflammation?
What type of functional, quantification and histological data is typically acquired?
Ganesh Halade, Ph.D.
Dr. Halade received training in cardiovascular sciences with a major focus on obesity and cardiac remodeling. After obtaining a Ph.D. degree in Pharmacology, he completed postdoctoral training with Dr. Merry Lindsey at the San Antonio Cardiovascular Proteomics Center and Barshop Institute for Longevity Studies in Aging at the University of Texas Health Science Center at San Antonio. Dr. Halade has spent more than 7 years working on obesity and is now focusing on the regulation and dysregulation of inflammation and resolution following myocardial infarction in the setting of obesity. He is working on leukocyte kinetics, immune responsive fatty acids metabolism, and their role in an inflammation resolution signaling. Early in his research career, Dr. Halade worked to segregate the distinct effect of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in lupus. In May 2013, Dr. Halade joined the Division of Cardiovascular Disease in the Department of Medicine at the University of Alabama at Birmingham where he spent almost 7 years. Dr. Halade is currently an Associate Professor in the Department of Medicine, Division of Cardiovascular Sciences, Heart Institute, at the University of South Florida in Tampa, FL.