Overview:

In this webinar, Katie discussed the role hypoxia plays in disease progression and treatment response, specifically in cancer. She also explained the various molecular imaging technologies that can be used to visualize and assess hypoxia in preclinical cancer models. Some modalities that were covered include magnetic resonance imaging (MRI), positron emission tomography (PET), and optical imaging. 

Topics Covered:

  • What is hypoxia?
  • Is there a link between hypoxia and cancer?
  • What imaging modalities can be used to visualize hypoxia in vivo?
  • What are the advantages and limitations of each technique?
  • What are some applications of hypoxia imaging?

Hypoxia has been shown to influence many facets of cancer including tumor growth, treatment response, and metastatic potential. Thus, the ability to noninvasively visualize hypoxia in vivo may be critical to understanding the underlying tumor biology, guiding treatment plans, and determining prognosis in the clinic.

Many different modalities have been used for preclinical hypoxia imaging. While some techniques have been around for decades and have extensive data behind them, others are emerging technologies that aim to overcome existing limitations in the field. Choosing the right modality can be challenging and is dependent on experimental conditions including tumor model, animal strain, and the desired measurement, as each technique will target a different aspect of hypoxia. In this webinar, we will discuss some molecular imaging techniques that can be used to visualize and characterize tumor hypoxia including MRI, PET, optical, and PAI. We will compare the various options, discuss the advantages and limitations of each approach, and show some examples of how scientists are using these techniques within their research.

References

Rebecca A. D’Alonzo, Suki Gill, Pejman Rowshanfarzad, Synat Keam, Kelly M. MacKinnon, Alistair M. Cook & Martin A. Ebert (2021) In vivo noninvasive preclinical tumor hypoxia imaging methods: a review, International Journal of Radiation Biology, 97:5, 593-631, DOI: 10.1080/09553002.2021.1900943

Presentation and Video:

On Demand
Slide Deck
Questions

About the Speaker:

Katie Parkins

Katie Parkins, Ph.D.

Head of Scientific Division

Katie Parkins holds a Ph.D. from the University of Western Ontario in Medical Biophysics. Throughout her research training, she was focused on the development and application of novel molecular imaging tools to monitor and treat disease, specifically, cancer. Additionally, Katie completed a Postdoctoral Fellowship at Johns Hopkins University where she used multimodal imaging to investigate the molecular mechanisms that may determine immunotherapy response. In her present role as Head of Scientific Integration at Scintica, Katie supports our customers in understanding the products offered and how these instruments help to meet their research needs.