Vascular function is regulated by multiple factors such as endothelial and smooth muscle cells, inflammatory cells and the autonomic nervous system. It can be assessed with invasive or non-invasive methods in vivo, and with ex vivo isolated tissue methods. Impaired vascular function may be indicative of atherosclerosis and other cardiovascular diseases.
Pulse Wave Velocity
Pulse Wave Velocity is the velocity at which a pulse of blood travels through the vasculature. It is a measure of arterial stiffness, often used to assess hypertension and atherosclerosis. The Doppler Flow Velocity System is ideal for pulse wave velocity measures as two non-invasive probes can be positioned simultaneously to detect the same pulse of blood.
The small vessel wire myograph systems enables ex vivo assessment of vascular reactivity. These systems are suitable for pharmacological studies of dissected vascular rings. The measuring unit is removable, and can be used with a microscope to make mounting vessel rings easier. An isometric tension sensor quantifies vascular contraction and relaxation.
The modular tissue bath system is suitable for use with smooth or striated muscle samples. Tissue and vessel ring holders enable the study of vessel rings and muscle tissue samples, adding to the versatility of the system. Force/displacement sensors quantify tissue reactivity, and the system can be coupled to a data acquisition system for data analysis.
The OxyLite system uses fluorescence quenching and fiber optic technology to quantify the absolute dissolved oxygen content of tissues. The OxyFlo is a laser Doppler tissue blood flow/perfusion monitor. Systems can be configured with many different sensors, and combined systems simultaneously measure tissue oxygen, blood flow and temperature.