Rats are essential for a wide variety of research models, as they enable researchers to elucidate the pathogenesis of numerous diseases, and develop novel therapeutics. We offer laboratory solutions for anesthesia and surgical monitoring essentials, as well as more advanced tools such as telemetry, Doppler Flow Velocity systems, tissue oxygen and perfusion measurement systems, several blood pressure monitoring options, and a fluorescence endomicroscope to study a wide variety of disease models.
Chronic monitoring of physiological parameters is made possible with telemetry. The Indus Instruments telemetry system enables ECG, temperature and activity recording in rats. The Kaha Sciences telemetry system enables biopotential, pressure, sympathetic nerve activity and oxygen measurement. Telemetry enables long-term studies, and reduces animal stress from repeated handling.
There are multiple methods for assessing cardiovascular function in rat models of disease. We offer a variety of solutions for in vivo and in vitro measurement, as well as options for chronic measurement in a variety of rat models. These systems are suitable for assessing a wide range of parameters including blood flow velocity, isolated heart function, ECG, blood pressure and more.
We offer acute and chronic ECG measurement systems. For acute recordings, the Rodent Surgical Monitor⁺ (RSM⁺) enables non-invasive ECG measurement streamed to a display tablet. For studies that require chronic ECG measurement, Kaha Sciences telemetry and Indus Instruments enable long-term recordings in conscious, free moving rats and can be integrated with a data acquisition system for analysis.
Rat blood pressure may be measured invasively or non-invasively. The NIBP tail cuff system enables pressure measurement in up to six rats simultaneously. Alternatively, pressure catheters integrated with the RSM⁺ enable acute vascular or ventricular pressure measurements coupled to vital signs. Kaha Sciences telemeters are suited for chronic single or dual pressure measurements.
There are multiple techniques to assess vascular function in rat models. Non-invasive pulse wave velocity can be quantified with the Doppler Flow Velocity System, whereas the OxyLite and OxyFlo systems are minimally invasive and quantify dissolved oxygen and tissue perfusion. Wire myographs and tissue baths are suitable for ex vivo assessment of vascular reactivity.
In vivo confocal microscopy
The FIVE2 (ViewnVivo) from Optiscan is a miniaturized fluorescence endomicroscope that enables in vivo imaging in rat and rodent models. Using patented Point Scanning Technology, the system captures full field of view images of cellular and sub-cellular structures. The system can be used to generate 3D visualizations through continuously variable depth control.
Anesthesia and ventilation
Anesthesia systems are laboratory essentials. UNO BV anesthesia systems are designed especially for low flows, incorporate active waste gas scavenging and have nose cones and induction boxes designed for rats. The ventilator features positive end-expiratory settings, and is suitable for use in rats as large as 700 grams.
Surgical monitoring is important for meeting IACUC guidelines and ensuring successful surgical procedures. The Rodent Surgical Monitor⁺ (RSM⁺) integrates a heating platform with a touchscreen tablet for ECG, heart rate, respiration, and temperature monitoring. Optional pulse oximetry and vascular/ventricular pressure modules increase functionality.
MRI is the gold standard in soft tissue imaging. The M-seriesTM compact MRI system from Aspect Imaging provides anatomical and morphological images to pre-clinical researcher focused on a variety of rat (rodent) disease models including cancer, neurology, cardiovascular, inflammation, obesity & diabetes, as well as specific organ diseases and developmental biology.