Newton 7.0

In Vivo Optical, Fluorescence & Bioluminescence, Imaging

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System Overview

The Newton 7.0 is a cutting-edge optical imaging system that offers the versatility to perform bioluminescence, fluorescence, and 3D tomographic imaging in a single device. Its user-friendly interface and advanced features make it ideal for in vivo, ex vivo, and in vitro imaging applications, as well as simultaneous imaging of multiple specimens.

The system features a state-of-the-art 4.6 megapixel CCD camera that boasts one of the largest apertures in the market. This camera provides excellent sensitivity for a variety of luciferase enzymes and fluorophores commonly used in preclinical research, allowing for fast and efficient signal acquisition. The intuitive workflow and user-friendly software are optimized for multi-user use, saving valuable time in longitudinal studies.

Features & Benefits

The Newton 7.0 is an innovative optical bioluminescence, fluorescence, and 3D tomographic imaging system designed with the user in mind.

State-of-the-art Camera Technology

Scientific grade 0 16-bit CCD
4.6 MP Native Resolution
-90oC Absolute Cooling
f/0.7 Lens Aperture
10 MP Image Resolution
4.8 Optical Density

Powerful Fluorescent Excitation

The Newton 7.0 features eight excitation channels across the visible and near-infrared spectrums. Two powerful Laser Class II arrays tightly control the illumination light, delivering a direct, high-intensity light.

Motorized Darkroom with Adjustable Field-of-View

Vilber’s intelligent darkroom architecture allows for a fully motorized movement of the camera (Z-axis) and animal pad (X/Y axis) to move through both the macro imaging FOV (6x6cm) to the full FOV (20x20cm) for imaging up to 5 mice.

Full Spectrum Tunability

Powerful with 8 excitation channels and 8 emission filters that cover the complete spectrum from blue to infrared.

Hard-coated narrow bandpass filters are used for the collection of emission wavelengths to reduce cross talk between signals, allowing for seamless imaging of all of the most commonly used fluorophores.

3D Optical Tomography

An integrated 3D tomography module allows for bioluminescent signals to be reconstructed in 3D and overlaid within a topographical model of the imaging subject.

The digital organ and bone library allows for the superimposition of the mouse organs and bones onto the topographical model to better understand anatomical and deeper tissue structures.

License-Free Acquisition and Analysis Software

The user-friendly software comes with unlimited licenses and free updates.

New and experienced users can quickly image their subjects using factory default acquisition protocols or create custom acquisition protocols.

Fully GLP and CFR21-compliant data can be exported in 16-bit .tiff or 8-bit .jpg formats.

In the analysis module, save ROI and analysis templates for high throughput analysis of up to 10 images side by side.

Imaging Modes

Fluorescence Imaging

Fluorescence imaging

Fluorescence imaging can be used to detect fluorescent reporter genes or dyes in vivo using Vilber’s dynamic range of emission filters.

Subcutaneous tumor expressing mCherry

Bioluminescence Imaging

Bioluminescence imaging

Bioluminescence imaging can be used to detect luciferase expressing or secreting molecules in the tissue of interest

Subcutaneous tumor expressing firefly luciferase

Multispectral In Vivo Imaging

Multispectral Imaging

Multispectral in vivo imaging is possible by using different luciferase enzyme/substrate pairs or by using different fluorescent dyes. Up to 3 signals can be overlaid within the same image.

Multispectral imaging

Longitudinal Imaging

Images that are acquired at different time points can be arranged to form a longitudinal image sequence.
For example, a time series could be constructed from images acquired on different days following an experimental treatment.
Software then compares the image data throughout the experimental treatment.

Models & Specifications

3 & 5 Mice

In Vivo / In Vitro Optical imaging platform
Bioluminescence Detection
3D Optical Tomography

3, 5 & 10 Mice

In Vivo / In Vitro Optical imaging platform
Bioluminescence Detection
3D Optical Tomography
Fluorescence Detection

POPULAR

Plant Imaging

In Vivo / In Vitro Optical imaging platform
Bioluminescence Detection Fentogram
Fluorescence Detection Picogram

POPULAR

All Models

16-bit Scientific Grade CCD Camera
Cooling: -90°C absolute
Cooling: -120°C Delta

All Models

Proprietary V.070 – Fixed
Focal Length Motorized lens
Aperture: f/0.7

All Models

Resolution: 2160×2160
Monochrome & Color Imaging

All Models

11-Position motorized filter wheel for all models
8 Narrow Band-pass filters included as standard 500 / 550 / 600 / 650/ 700/ 750 / 800 / 850 nm

Excitation

	BT100	BT500	FT100	FT500	BIO
White-Light	Dual EPI-White Light LED Panels	Dual EPI-White Light LED Panels	Dual EPI-White Light LED Panels	Dual EPI-White Light LED Panels	Dual EPI-White Light LED Panels
Fluorescence	Upgradeable to Fluorescence	Upgradeable to Fluorescence	8 Fluorescent Channels Included 420 / 480 / 520 / 580 / 640 / 680 / 740 / 780nm	8 Fluorescent Channels Included 420 / 480 / 520 / 580 / 640 / 680 / 740 / 780nm	8 Fluorescent Channels Included 420 / 480 / 520 / 580 / 640 / 680 / 740 / 780nm

Emission

	BT100	BT500	FT100	FT500	BIO
Filter Wheel	11-position Motorized Filter Wheel	11-position Motorized Filter Wheel	11-position Motorized Filter Wheel	11-position Motorized Filter Wheel	11-position Motorized Filter Wheel
Emission Filters	4 Narrow Band-pass filters included for BLI Tomography: 500/550/600/650nm	4 Narrow Band-pass filters included for BLI Tomography: 500/550/600/650nm	8 Narrow Band-pass filters included: 500/550/600/ 650/700/750/800/850nm	8 Narrow Band-pass filters included: 500/550/600/650/ 700/750/800/850nm	8 Narrow Band-pass filters included: 500/550/600/650/ 700/750/800/850nm

Darkroom

	BT100	BT500	FT100	FT500	BIO
Motorization	Fixed Camera Fixed Animal Stage	Z-Axis Motorized Camera X/Y-Axis Motorized Animal Stage	Fixed Camera Fixed Animal Stage	Z-Axis Motorized Camera X/Y-Axis Motorized Animal Stage	Z-axis Motorized Camera 15° Tilting Sample Stage
Animal Handling	Heated Mouse Bed (+37°C) included Animal breathers included	Heated Mouse Bed (+37°C) included Animal breathers included	Heated Mouse Bed (+37°C) included Animal breathers included	Heated Mouse Bed (+37°C) included Animal breathers included	Not Applicable

Heated Mouse Bed (+37°C) (included)

Animal breathers (included)

(Not Included with Newton 7.0 BIO)

Accessories / Add-ons

	BT100	BT500	FT100	FT500	BIO
Monitorization	Fixed Camera Fixed Animal Stage	Z-Axis Motorized Camera X/Y-Axis Motorized Animal Stage	Fixed Camera Fixed Animal Stage	Z-Axis Motorized Camera X/Y-Axis Motorized Animal Stage	Z-axis Motorized Camera 15° Tilting Sample Stage