The Prospect T1 has been specifically designed for preclinical imaging of small animals including mice and rats. These species require very high resolution images (up to 30µm) to observe anatomical structures, and considerations to monitor changes in hemodynamics due to their high heart rates. This tablet based, high frequency, compact ultrasound system is a cost effective alternative to other preclinical ultrasound systems on the market, allowing individual labs to harness the power of this real-time imaging modality.
The system is well equipped with standard ultrasound capabilities including B-mode, EKV mode, M-mode, Color and Power Doppler, Pulsed Wave Doppler, Tissue Doppler, and Contrast imaging (reference subtracted and harmonic options are available). Additionally the system’s capabilities may be expanded by adding on a 3D motor to acquire 3D B-mode images, integration of a sonoporation probe for use with microbubbles, or push probe to perform shear wave elastography, and finally an integrated injection mount can also be used to aide in image guided injections.
The standard configuration and capabilities of the Prospect T1 allow for researchers with a wide variety of research interests to utilize the system; these applications include cardiovascular research, cancer biology, general abdominal/anatomical imaging, developmental biology, as well as ophthalmology applications. The suite of analytical tools and measurement packages allow imagers to quickly generate quantitative results over the course of their longitudinal studies.
Included with the system is the scanning platform which may be equipped with either a heated mouse or rat sized bed, which has integrated physiological monitoring. This platform has been ergonomically designed to allow for easy positioning of the ultrasound probe, while being easy to clean as needed between imaging subjects.
Currently there are three different single element probes available, the choice of which to use is dependent on the animal to be imaged and the anatomical targets. The PB406e probe has a user selectable broadband frequency of between 30 – 50 MHz with a center frequency of 40MHz, with its main application being for mice and superficial imaging targets on other species. The PB506e probe has a user selectable broadband frequency of between 30-50MHz, with a center frequency of 50MHz.The PB207e probe ranges in frequency from 15 – 30 MHz, which again is user selectable, with its main application for rats and harmonic contrast imaging.
The system operates using a touch screen tablet, the user interface has been designed with the pre-clinical researcher in mind. Animal and study information can be entered at the start of an imaging session and is associated with all of the saved images. Depending on the imaging application the data may be saved in a RAW format if the raw radio frequency data is required, or cineloop format for further measurements and analysis. Additionally, there are options to simply save tiff/jpg/bmp images or avi files for presentation. Offline data analysis is also available to ensure that the system time is reserved for image acquisition, while data can be transferred to an analysis station to perform measurements as needed.