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You are here:///Combined Systems – Oxford Optronix
Combined Systems – Oxford Optronix2018-11-07T10:19:43+00:00

OxyLite™ and OxyFlo™

Single-channel combined oxygen, temperature and laser-Doppler tissue blood perfusion monitoring (stacked single-channel OxyLite™ and OxyFlo™ monitors)

OxyLite Brochure
OxyFlo Brochure
Oxford Optronix - OxyLite and OxyFlo

OxyLite™ Pro and OxyFlo™ Pro

Combined TWO or FOUR channel oxygen, temperature and laser-Doppler tissue blood flow monitoring, with integrated touch-screen displays (stacked multi-channel OxyLite™ Pro and OxyFlo™ Pro monitors)

OxyLite Pro Brochure
OxyFlo Pro Brochure
Oxford Optronix - OxyLite Pro and OxyFlo Pro

Overview

One of the most powerful and unique features offered by Oxford Optronix tissue vitality monitors is the ability to measure tissue oxygen, laser-Doppler blood flow and temperature simultaneously from the same tissue micro-region. This is achieved by combining counterpart monitors into a ‘stack’ arrangement and the use of the unique, combined, multi-parameter sensors.

The use in this way of a 4-channel OxyLite™ Pro XL and a 4-channel OxyFlo™ Pro XL device enables the collection of multi-parameter physiological data from up to four independent tissue sites at one time, providing unsurpassed data collection and productivity potential.

Please refer to the individual product pages for in-depth key features and benefits.

Applications in which Oxford Optronix OxyLite™ and OxyFlo™ monitors have been employed together for the simultaneous, single-sensor monitoring of tissue oxygen, blood perfusion and temperature include:

  • Tumour angiogenesis

  • Vital organ vitality during transplantation and shock monitoring

  • Cerebral vitality monitoring during stroke

  • Brain and spinal cord injury models

  • Tissue flap surgery and wound healing

Statement of intended use:
OxyLite™ (Pro) and OxyFlo™ (Pro) monitors are intended for laboratory, industrial and research use and are NOT medical devices.
OxyLite™ (Pro) and OxyFlo™ (Pro) do NOT possess regulatory approval(s) for use in human subjects/patients.

Oxford Optronix - Made In Britain

Data Example

A Model of Global Ischaemia/Reperfusion Injury in Rat

A single, combined oxygen/blood flow/temperature sensor was used to invasively measure the effect of transient global cerebral ischaemia induced by common carotid artery occlusion. The upper trace shows pO2 in units of mmHg, the middle trace shows temperature in units of degrees C, while the lower trace shows continuous blood flow in arbitrary ‘blood perfusion units’ (BPU).

Click the data set image to view full screen.

Oxford Optronix - Combined Systems - Global Ischaemia/Reperfusion Injury in Rat

User Testimonials

“I found Oxford Optronix´s group of experts to be knowledgeable, friendly and supportive with regular feedback capable to overcome any challenge. The [OxyLite / OxyFlo] system offers a broad range of in vivo applications that provided us the data we require.”
– Prof. Martin Matejovic, Charles University and Teaching Hospital, Plzen, Czech Republic

“.. great products with tremendous support. The knowledgeable members of your team are always extremely helpful. The OxyLite and OxyFlo units have been a great asset to our research”
– Dr Gregory Hare, University of Toronto, St. Michael’s Hospital, Toronto, Canada

“We use OxyFlo Pro and OxyLite Pro devices in our piglet experiments that focus on validating the non-invasive modalities of quantifying cerebral pressure autoregulation and neurovascular coupling. This is an ongoing project to understand elucidate the mechanisms of brain injury in critically ill infants. We are extremely satisfied with the Oxford Optronix devices. Their customer support service is phenomenal.”
– Dr Rathinaswamy Govindan, Children’s National Medical Center, Washington DC, United States

“We collaborate with Oxford Optronix for several years now. Oxford Optronix provided us with an excellent technical support during our efforts in the field of multi-parametric neuro-monitoring. We are impressed not only by their products but also by their commitment to develop cutting edge products for experimental and clinical neuroscience.”
– Dr Beat Alessandri, University Medical Center of the Johannes Gutenberg-University, Germany

“In [our] experiments we measure: continuous, relative cortical CBF with your laser Doppler implanted probes, intermittent, but absolute CBF with fluorescent-labelled microspheres, cortical tissue pO2 with your implanted [sensors], cerebral arterio-venous difference and thus the cerebral metabolic rate for O2 by having a sagittal sinus catheter, and electroencephalogram (EEG) for neuronal activity and “sleep state”. Technologically, the experiments are quite a Tour de Force. I thank you, because without the technological expertise Oxford Optronix provides, we could not perform these studies.”
– Prof Lawrence Longo, Loma Linda University, CA, United States

“In our studies on the response to gas inhalation in abdominal organs, OxyLite and OxyFlo allowed us to monitor tissue pO2 and perfusion response simultaneously in the liver and kidney. No other minimally invasive system could capture dynamic changes with such fine temporal resolution, and no other system could provide concurrent pO2 and perfusion measurement in multiple tissue regions. Oxford Optronix enabled us to understand the physiological phenomena underlying our magnetic resonance imaging measurements. It is truly a powerful, must-have technology.”
– Dr Hai-Ling Margaret Cheng, University of Toronto, Hospital for Sick Children, Toronto, Canada

“We are currently using … the OxyLab LDF and the … OxyLab pO2 … in animal experiments to take recordings in brain tissue. Both of these monitoring systems have proven of great value in studies on focal brain ischemia and reperfusion, in which we have addressed the role of collateral blood flow on tissue perfusion, oxygen supply, and the development of ischemic brain damage. A publication of these data is presently in preparation.”
– Prof Lothar Schilling, Universitätsklinikum, Mannheim, Germany

Literature Citations

Research areas in which Oxford Optronix OxyLite™ and OxyFlo™ monitors have been combined to provide simultaneous measurements of tissue oxygen, blood flow and temperature are numerous. Click any abstract to view online, or click DOWNLOAD CITATIONS PDF for a complete list of all known literature citations.

Please note that this PDF contains a mix of articles citing the use of OxyLite™ and OxyFlo™ in isolation, as well as articles demonstrating their use for combined parameter monitoring.

Selected Citations

Ophthalmology

Lim JK, Nguyen CT, He Z, Vingrys AJ and Bui BV, The effect of ageing on ocular blood flow, oxygen tension and retinal function during and after intraocular pressure elevation. PLoS One (2014); 9(5), e98393 [LINK]

Instruments cited: OxyLab pO2™ and OxyLab LDF™

Current product: OxyLite™ and OxyFlo™ &trade

Physiology/Ischaemia

Radiloff D, Zhao Y, Boico A, Blueschke G, Palmer G, Fontanella A, Dewhirst M, Piantadosi CA, Noveck R, Irwin D, Hamilton K, Klitzman B, Schroeder T,  Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude. PLoS One (2014); 9(6), e99309 [LINK]

Instruments cited: OxyLite™ 2000 and OxyFlo™ 2000

Khan MA, Maasch C, Vater A, Klussmann S, Morser J, Leung LL, Atkinson C, Tomlinson S, Heeger PS, Nicolls MR., Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Proc Natl Acad Sci USA (2013); 110(15), 6061-6 [LINK]

Instruments cited: OxyLab pO2™ and OxyLab LDF™

Nasui1 OC, Nathanael G, Miller E, Belik J, Crawley A, Weiss R, Detzler G, Zhong A, Moineddin R and Doria AS, Responsiveness of BOLD MRI to Short-Term Temperature Changes in Rabbit Knees with Inflammatory Arthritis. Rheumatol Curr Res (2012); S2 http://dx.doi.org/10.4172/2161-1149.S2-003 [LINK]

Instruments cited: OxyLite™ 2000 and OxyFlo™ 2000

Vital Organs/Shock

Calzavacca P, Evans RG, Bailey M, Lankadeva YR, Bellomo R and May CN, Long-term measurement of renal cortical and medullary tissue oxygenation and perfusion in unanesthetized sheep. Am J Physiol Regul Integr Comp Physiol (2015); 308(10):R832-9 [LINK]

Instruments cited: OxyLite™ 2000 and OxyFlo™ 2000

Patel NN, Toth T, Jones C, Lin H, Ray P, George SJ, Welsh G, Satchell SC, Sleeman P, Angelini GD, Murphy GJ, Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade. Crit Care Med (2011); 39(4): 793-802 [LINK]

Instruments cited: OxyLab pO2™ and OxyLab LDF™

Dyson A, Stidwill R, Taylor V and Singer M, Tissue oxygen monitoring in rodent models of shock. Am J Physiol Heart Circ Physiol (2007); 293, H526–H533 [LINK]

Instruments cited: OxyLite™ 2000 and OxyFlo™ 4000

Cerebral/Stroke/MCAO

Hsu CC, Chen LF, Lin MT, Tian YF, Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats. Int J Endocrinol (2014); 134575 [LINK]

Instruments cited: OxyLite™ 2000 and OxyFlo™ 2000

Jan Mazela, T. Allen Merritt, Michael H. Terry, Timothy J. Gregory and Arlin B. Blood, Comparison of poractant alfa and lyophilized lucinactant in a preterm lamb model of acute respiratory distress. Pediatric Research (2012); 72, 32–37 [LINK]

Instruments cited: OxyLite™ 2000 and OxyFlo™ 2000

Lee WC, Wen HC, Chang CP, Chen MY and Lin MT, Heat shock protein 72 overexpression protects against hyperthermia, circulatory shock, and cerebral ischemia during heatstroke. J Appl Physiol. (2006); 100(6), 2073-82 [LINK]

Instruments cited: OxyLite™ 2000 and OxyFlo™ 2000

Tumour/Cancer

Kieda C, Hafny-Rahbi B, Collet G, Lamerant-Fayel N, Grillon C, Guichard A, Dulak J, Jozkowicz A, Kotlinowski J, Fylaktakidou KC, Vidal A, Auzeloux P, Miot-Noirault E, Beloeil JC, Lehn JM, Nicolau C., Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatmentJ Mol Med (Berl) (2013); 91(7), 883-99 [LINK]

Instruments cited: OxyLite™ 2000 and OxyFlo™ 2000

Specifications for Combined Systems

For instrument specifications please refer to respective OxyLite and OxyFlo product pages.

Frequently Asked Questions

Do I need separate instruments to measure all supported parameters?

Yes, Oxford Optronix instruments are provided as modular units for enhanced user flexibility and therefore both an oxygen monitor and a blood flow monitor are required to drive the combined, multi-parameter sensors. Oxford Optronix multi-parameter, combined sensors feature two connectors, one for each monitor type. Normal configuration involves ‘stacking’ together either single-channel monitors or multi-channel monitors. Potentially a mix of single and multi-channel monitors can be used.

Are Oxford Optronix multi-parameter sensors MRI-compatible?

Oxford Optronix offers one combined oxygen and blood flow sensor that provides full MRI compatibility. This requires Oxford Optronix specialist oxygen/blood flow extension cable. Integrated temperature is not supported since this constitutes a metallic component.

Can I use more than one combined sensor at the same time?

Yes. Using a stack of dual-channel (Pro) or four-channel (Pro XL) monitors, up to two or up to four combined sensors can be driven simultaneously, potentially providing multi-parameter physiological data from up to four different tissue sites at the same time. This may be useful when comparing pathological versus control tissue sites or in mitigating for natural tissue variability by allowing multi-site data averaging.

Do Oxford Optronix monitors possess regulatory approval for clinical use?

At this time Oxford Optronix instruments and sensors do NOT possess CE or FDA regulatory approvals for use on human subjects.

Do you offer on-site demonstrations of your instruments?

Yes, depending on geographical location we will try to arrange for an on-site demonstration of our products by an experienced product specialist. Ideally this will involve a full simulation of your application in order to maximise the benefit of the demonstration. On-site demonstrations are usually free of charge and can typically be arranged at 2 – 8 weeks notice. Alternatively we can also arrange for a limited free trial of our monitors and sensors.

Sensors for Combined Oxygen and Blood Flow Monitoring

When used together (typically in the ‘stack’ arrangement depicted above), Oxford Optronix oxygen and blood flow monitors uniquely support combined parameter sensors for the simultaneous measurement of tissue oxygen, blood perfusion and temperature from the same tissue micro-region. The following is a list of available combined oxygen and blood flow parameter sensor types.

Oxygen sensors are supplied in sealed Tyvek® pouches.

Combined, Bare-Fibre Oxygen/Blood Flow Sensor
Product Code: ‘NX-BF/OF/E’

Oxford Optronix - Combined Systems - Product Code 'NX-BF/OF/E'

Flexible, minimally invasive sensor suitable for localized , combined tissue oxygen and blood flow measurements from virtually any tissue type in vivo.

  • Tissue placement via introducer (e.g. Angiocath®)
  • T-90 response time approx. 20 s
  • Manual temperature compensation
  • Removable/adjustable Luer
  • MRI compatible

Dimensions:

  • Tip diameter: approx. 450 µm
  • Exposed tip fibre length: 6 cm
  • Total sensor length: 2.5 m

Reusability: Limited due to fragility

NOTE: THIS SENSOR TYPE IS ALSO AVAILABLE IN 8 M LENGTH FOR MRI APPLICATIONS

Combined, Bare-Fibre, Triple-Parameter Oxygen/Blood Flow/Temperature Sensor
Product Code: ‘NX-BF/OFT/E’

Oxford Optronix - Combined Systems - Product Code 'NX-BF/OFT/E'

Flexible, minimally invasive sensor suitable for localized , combined tissue oxygen, blood flow and temperature measurements from virtually any tissue type in vivo.

  • Tissue placement via introducer (e.g. Angiocath®)
  • T-90 response time approx. 20 s
  • Manual temperature compensation
  • Removable/adjustable Luer

Dimensions:

  • Tip diameter: approx. 450 µm
  • Exposed tip fibre length: 6 cm
  • Total sensor length: 2.5 m

Reusability: Limited due to fragility

Optional Accessories

For available accessories please refer to respective OxyLite and OxyFlo product pages.

Measuring Tissue Perfusion and PO2 in Conscious Animals to Investigate Organ Failure

To watch the complete webinar click here