Small Animal Implantable Telemetry

The Indus Small Animal Telemetry System and associated wireless implants offer a simplified and cost-effective approach to studying physiology in conscious, unrestrained small animals. Scientists are able to monitor ECG, Heart Rate, Core Body Temperature and Activity in multiple, socially housed, animals simultaneously.

The system consists of four core components:

  • Telemetry Communication Module
  • Wireless Charging Station  
  • Wireless Implant
  • Data Acquisition Software

ECG

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Subcutaneously-sutured leads allow researchers to record high-resolution heart rhythm free of anesthesia.

Temperature

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Core Temperature can identify changes in circadian rhythm, inflammatory response, environment, and more.

Activity

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Accelerometers provide data useful for identifying circadian rhythm and general subject movement.

Heart Rate

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High frequency measurements allow researchers to track long-term and short-term autonomic responses.

Wireless Data Transfer and Charging

Advanced wireless technology allows one benchtop station to collect data from multiple subjects simultaneously. Included wireless implant chargers allow implants to record in subjects for extended periods.

Communication Module Specifications
Communications CapacityUp to 100 implants
Communication RangeUp to 5 meters (~16 feet)
ConnectorUSB Mini, Type B
Antenna2, External
Size6.0 x 3.5 x 1.0 inches
Weight0.4 pounds
SAT Communication Module - Indus Instruments
Under the Cage Wireless Charger Specifications
Charging CapabilityOne Unit will Recharge All Devices withing a Standard Mouse Cage
Charging DistanceUp to 5cm from Charger Surface
Charging Frequency13.56MHz ISM Band
Power SourceStandard USB Wall Charger, Input: Universal AC, Output: DC 5V 0.5A USB
Dimensions250mm x 170mm x 20mm
Weight0.4 Kg
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Wireless Implants

These small biocompatible devices are surgically implanted subcutaneously or within the subject’s peritoneal cavity, with ECG leads sutured to the pectoral muscles, one on each side of the chest. Once implanted, the devices can be wirelessly set to automatically collect ECG, heart rate, core temperature, and activity data at defined time periods and intervals.

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Wireless Implants – General Specifications
ModelC19BTA
Volume1.9 cc
Weight2.7 grams
Body ShapeRectangular Solid
Size7.0 x 12.5 x 23.0 mm
Subject WeightSubcutaneous: >20g Interperitoneal: >25g
Measurement Specifications – Biopotential (ECG) & Heart Rate
Sampling Frequency1024Hz or 512Hz
Input Voltage Range±5mV
Electrode TypeFlexible, trimmable & repairable
Electrode Lead Length20 cm, customizable
Heart Rate Reporting Frequency1Hz when ECG active
Measurement Specifications – Activity
Sensor TypeOnboard Accelerometer
Sampling Frequency6 Hz
Max Reporting Frequency1 sample/5 seconds (1x/5 sec)
Reporting Frequency Options1x/5 sec, 1x/15 sec, 1x/30 sec, 1x/1 min, 1x/5 min, 1x/15 min
Measurement Specifications – Temperature
Max Sampling Frequency1 sample/0.5 seconds
Sampling Frequency1x/0.5 sec, 1x/1 sec, 1x/5 sec, 1x/15 sec, 1x/30 sec, 1x/1 min, 1x/5 min, 1x/15 min
Range0-50°C
Accuracy0.1°C (Initial Calibration)
Resolution0.1°C
Measurement Specifications – Battery & Memory
Battery TypeRechargeable
Battery Life Off Charger5 Days
Battery Charge Time7 Days
Onboard Data Capacity1GB
Useful Device Life> 1 Year

Features that help you do better science…

  • Rechargeable Batteries

    scientists can collect longitudinal data for longer duration and reuse implants in new subjects

  • Automatic Recording

    once configured, implants start and stop recording data automatically, eliminating stress from unnecessary handling

  • Social Housing

    unique implant IDs permit multiple animals per cage, improving surgical recovery and optimizing throughput

  • Onboard Memory

    no gaps in data: record during behavioral tests and transfer the data once the subject is back in its cage

Data Acquisition Software

The Indus Rodent Implantable Monitor software connects to the wireless transfer module and provides a station to view and configure implants, monitor a subject’s current vital signs, and review recorded data.

Acquisition & Analysis Functions:
Implants can be set to record data for specific durations and intervals. Collected data can then be reviewed on the Rodent Implantable Monitor laptop workstation. Data can be exported into standard formats, such as .CSV, permitting further analysis and data management through various software programs.

Telemetry System Dashboard - Indus Instruments

The Three Rs of Animal Research

The 3Rs (Replacement, Reduction, and Refinement), introduced in 1959 by William Russell and Rex Burch and discussed more frequently in the past 15 years, serve as guidelines when designing experiments involving animals. The Doppler Flow Velocity System embraces these concepts in its design and everyday use.

  • By collecting data serially, researchers are able to both gather more data and gain extra control over variability – Reducing the number of animals potentially required used per study.

  • Refining catheter-based or other invasive measurements by using noninvasive handheld probes decreases unnecessary pain.

  • Further, the small diameter of these probes allow measurements that would be difficult or impossible with systems with larger footprints.