Rodent Surgical Monitor+

The Indus Rodent Surgical Monitor+ is an advanced, integrated surgical warming and vital signs monitoring solution for preclinical research in mice, rats and other small animals. The system provides detailed information, in real time, regarding subject body temperature, ECG, heart rate, pressure and respiration.

A standard setup consists of three components:

  • Touchscreen Display Unit
  • Heated Surgical Platform 
  • Temperature Probe

Optional components:

  • Pulse Oximetry Thigh Clip
  • Pressure Adapter Cable and Pressure Catheter  
  • External Needle Electrodes
Brochure
SpecSheet
REFERENCES
Resources

Temperature

IndusInstruments_BT_icon1-200x200

Core body temperature is measured by rectal probe and regulated via the Heated Surgical Platform.

ECG

IndusInstruments_ECG_icon1-200x200 - Copy

High-resolution multi-lead ECG measured by noninvasive paw or subcutaneous needle electrodes.

Heart Rate

IndusInstruments_Activity_Icon1-200x200

Heart rates between 60 – 999 bpm are automatically calculated from the R peaks of the ECG signal.

Respiration

IndusInstruments_Resp_icon1-200x200

Properly titrate anesthesia based on respiration rate, measured using electrical impedance.

Pressure

IndusInstruments_HR_icon1-200x200 - Copy

Measure high fidelity arterial and ventricle pressure in mice and rats using a solid state pressure catheter.

SPO2

Measure arterial blood oxygenation non-invasively in mice and rats using a thigh clip sensor.

Touchscreen Display Unit

Configurable, clear waveforms and numeric panels provide information to monitor subject physiological status. Recording, playback and export functions are included to make data collection easy.

Touchscreen Display Unit
Type High Resolution Color with Capacitive Touch
Size & Resolution 10.1 Inches; 2560 x 1600 pixels
Storage Capacity 25 GB available
Power Supply Universal Adapter (100 – 240 VAC)
Connection to the Heated Surgical Platform Wireless or optional USB-C

Physiologic Measurements

Measurement Range
Heart Rate (Lead I, II, II) 60-999 BPM
Respiration Rate 15-400 BrPM
Core Temperature 0 – 50°C
Pad Temperature 25.0 – 43.5°C
R-R Interval (Lead I, II, III) 60 – 1000 ms
SpO2 * 80 – 100%
Pressure ** -50 – 300 mmHg
Waveform Display Options
ECG Lead I, II, III
ECG Lead aVL, aVR, aVF
Respiration
Respiration (from ECG)
Pulse Plethysmogram *
Pressure **

* SpO2 and Pulse Plethysmogram measurements require the “Pulse Oximeter software and clip”

** Pressure measurements require the “Pressure software upgrade and pressure catheters”

Features that help you do better science…

  • Real Time Monitoring

    clearly labelled numeric panels and measurement waveforms make it easy to monitor critical parameters

  • Customizable Presets

    define optimal study conditions and ensure consistency between subjects and collaborating labs

  • Easy Documentation

    a single image can capture animal ID, vital signs, study ID, researcher, date, time and all filter settings

  • Standalone Data Collection

    capture data, make comments and view recordings on the tablet to quickly take measurements and verify experiment details

Heated Surgical Platform

The surgical-grade stainless steel operating platform is easy to clean and disinfect, designed to support surgical best practices. It incorporates intelligent zone heating, ultra-low noise, high-resolution ECG electronics, noninvasive electrodes and a port for external needle electrodes for when subjects cannot be laid prone or supine.

Heated Surgical Platform
Dimensions 7.6 x 11.6 x 0.75 inches
Weight 3.4 pounds
Heater Type Responsive with Multiple Zone Control
Heater Uniformity < 0.5°C Across Active Area
Startup Time < 2 minutes from room temperature
Heater Set Temperature Adjustable, 25.0 – 43.5°C by 0.1°C
Power Supply Universal Adapter (100-240 VAC)
Noninvasive Electrodes Two sets of limb ECG contact electrodes; inner set for mouse, outer for rats or subjects of similar size
Optional External Electrodes 3.5mm 4-pole audio jack to four 13mm stainless steel needle electrodes

Temperature Probe

Each Rodent Surgical Monitoris delivered with a single rectal temperature probe. Customers may select between probes ideal for adult mice or for adult rats.

The temperature probe sensor is a Copper-Constantan Thermocouple, located at the tip of the probe. Probe temperature resolution is +/-0.1°C. Calibrated probe accuracy is +/-0.1°C at operating temperature.

IndusInstruments_MMS_Mouse_Thermocouple-e1480092531330 - Copy

Versatile

three sets of electrodes make it easy to work with small mice, large rats and many small animals in between

Dynamic

responsive electronic heating can respond to changing lab conditions within seconds, not minutes

Flexible

expansion modules allow you to easily add functionality later as your lab and study’s needs change

Pressure Catheter Option

The Pressure Catheter Option includes a software and firmware update, along with a catheter connection cable. When connected to an Indus pressure catheter, measurements of arterial and ventricular pressures can be performed. This adds another real-time continuous data stream to the Rodent Surgical Monitor+.

The Indus high fidelity rodent pressure catheters are specifically designed for use with mice and rats. These catheters have solid state sensors mounted at the tip that measure pressures with a high degree of precision. They are ideal for arterial, venous, or ventricular pressures due to the solid state sensor’s ability to accurately respond to minute and rapid changes in pressure.

Pressure Catheter Specifications
Available Sizes 1.2F and 1.6F
Sensor Type Solid state sensor, mounted at the tip of the catheter; pressure membrane recessed for protection
Catheter Material Polymide tubing, providing balance of flexibility and rigidity
Pressure Resolution 10uV/mmHg; higher than the industry standard
Pressure Amplifier Specifications
Input Pressure Range -50 – 300 mmHg
High Pass Filter Settings None
Low Pass Filter Settings Can be set to Off, 30Hz, 100Hz, 200Hz, 500Hz, or 1000Hz
Notch Filter Settings Can be set to Off, 50Hz, or 60Hz
Calibration Allows zero calibration and a high-point calibration

Pulse Oximetery Option

The Pulse Oximeter Option includes a software and firmware update, along with a sensor clip. This option allows you to noninvasively measure arterial blood oxygenation.  This adds another real-time continuous data stream to the Rodent Surgical Monitor+, providing valuable information about depth of anesthesia and ventilation efficacy.  Pulse oximetry has been mandated in hospital care for more than a decade: the preclinical research community has taken note of this and current NIH guidelines repeatedly suggest monitoring pulse oximetry during surgery and postoperative care to ensure correct anesthesia delivery and ventilation.

Cable Specifications
Pulse Rate Range 200-999 BPM
Pulse Rate Resolution 1 BPM
Sp02 Range 80% – 100%
Sp02 Resolution 1%
Connector Built-In Connector
Available Sensors Thigh Clip (Mouse & Rat)

4 or 8 Channel Analog Output Cable

The 4 or 8 Channel Analog Output Cable provides the capability to acquire raw data from the Rodent Surgical Monitor+, in real time, with virtually any data acquisition system. A total of four or eight output channels are included, each configurable for optimal data output. In addition, the cable can be used as an R-trigger for ultrasound imaging systems, as a TTL trigger for high-speed dual camera image capture systems and to supply data to many different brands of data acquisition systems.  Each channel can be individually configured with its own filtering options.

8 Channel also available
Analog Output Specifications
BNC Outputs 4 or 8 Channels
Sample Rate 4 kHz
DAC Resolution 14-bit
Output Impedance 75 ohms typical
Output Voltage ± 5V
Maximum Output Current 30mA short circuit current
Slew Rates 1.8V per microsecond
Settling Time 5µs typical
Linearity Error ± 1 LSB
High Pass Filtering Can be set to Off, 0.2Hz, 0.5Hz, 1Hz, 2Hz, 5Hz, or 10Hz
Low Pass Filtering Can be set to Off, 1Hz, 2Hz, 5Hz, 10Hz, 20Hz, 30Hz, 100Hz, 200Hz, 500Hz, or 1000Hz. There is also a 2000Hz hardware filter setting
Notch Filtering This filter suppresses cyclic 50Hz or 60Hz AC power line noise that can interfere with the instrumentation.
Available Signal Outputs
ECG Lead I, II, III ECG Lead II Trigger
Respiration Waveform Core Temperature
Pad Temperature Pulse Plethysmography (IR)
Pulse Plethysmography (R) Pressure

NRC Guide for the Care and use of Laboratory Animals

The Indus Rodent Surgical Monitor+ ensures scientist meet today’s laboratory standards as detailed by the NRC. The following are excerpts from the guide… to download a full copy, click here.

“Careful monitoring and timely attention to problems increase the likelihood of a successful surgical outcome. Monitoring includes routine evaluation of anesthetic depth and physiologic functions and conditions, such as body temperature, cardiac and respiratory rates and pattern, and blood pressure, and should be appropriately documented… Maintenance of normal body temperature minimizes cardiovascular and respiratory disturbances caused by anesthetic agents, and is of particular importance in small animals where the high ratio of surface area to body weight may easily lead to hypothermia.” [pg. 119]

“For anesthesia delivery, precision vaporizers and monitoring equipment (e.g., pulse oximeter for determining arterial blood oxygen saturation levels) increase the safety and choices of anesthetic agents for use in rodents and other small species.” [pg. 122]

NRC Guide for the Care and use of Laboratory Animals, 8th edition, 2011