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Articles2019-03-01T16:35:24-04:00

A Tale of Two Tubes: Exploring the Causes of Cardiovascular Disease from the Arteries to the Gut

The Integrative Cardiovascular Physiology laboratory at Colorado State University investigates the underlying causes of cardiovascular abnormalities in the settings of obesity and nutrient excess. Obese individuals are at an increased risk for developing cardiovascular disease (CVD)1. Prior to overt

Imaging Solutions for Preclinical Research: Imaging Modalities and Their Applications

With the ever-growing preclinical imaging field, it is difficult to know which imaging modality is ideal for your experiment. This brief overview aims to help researchers optimize their experiments and their funding by choosing ideal imaging modalities for their

Understanding oxygen sensing in cells: A video lecture by Dr. Peter Ratcliffe

The lecture “Elucidation of oxygen sensing pathways in human and animal cells; implications for Physiology” by esteemed professor Dr. Peter Ratcliffe of Oxford University delves into the topic of physoxia head on. Dr. Ratcliffe provides relevant and interesting data from

By |August 27th, 2019|Articles, Cancer Research, Hypoxia, Molecular, Physiology|

Investigating mechanisms driving acute kidney injury arising from heart surgery and sepsis

A team of researchers and clinicians at the Florey Institute of Neuroscience and Mental Health are investigating ways to reduce the incidence of kidney injury resulting from heart surgery and sepsis. Acute kidney injury is when our kidneys suddenly

Combating time and space issues in labs today: How a simple microscope is changing the way scientists do research

Combating time and space issue in labs todays: How a simple microscope is changing how scientists do research      All researchers today, from grad students to principle investigators, are lacking 2 key factors that were widely available a generation

By |June 10th, 2019|Articles, Cancer Research, Lab Equipment, Molecular, Physiology|

Cancer Biology and Magnetic Resonance Imaging (MRI): The Gold Standard of Soft Tissue Imaging

Magnetic resonance imaging (MRI) is a technique that utilizes magnetic fields to create images of the anatomy and the physiological processes within the body. Specifically, MRI, the gold standard in soft tissue imaging, offers researchers the ability to distinctly

A versatile tool for 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 vascular research

Vascular function can be assessed in vitro using a myograph. Benchtop wire myograph systems consist of an organ bath, mounting wire or prongs, a micrometer, and a force transducer and amplifier to measure tension development in the tissue. This

Is 1 tesla enough: How low-field MRI is permitting more preclinical researchers to utilize this gold standard technique than ever before

In my day to day interactions, I come across numerous researchers who are not able to fully utilize MRI systems as they would like or cannot see themselves using this technology even though it could immensely help their research.

By |May 6th, 2019|Animal Models, Articles, Cancer Research, Imaging, Molecular, Mouse, MRI, PET/CT, Rat|

The Importance of Cohousing During Telemetry Studies

Research animals must be housed under conditions that ensure their physiologic and behavioral needs are met.  These conditions influence animal well-being and the quality of data obtained throughout a study. Facilities are often designed with many of these factors

Cancer biology and High-Frequency Ultrasound: non-invasive identification, visualization, and quantification in a wide variety of preclinical tumor models

Ultrasound has become a widely used preclinical imaging modality that can be used to visualize a variety of internal structures within small animal models with high resolution (down to 30µm). This provides researchers with primary structural information in real-time

𝘐𝘯 𝘷𝘪𝘷𝘰 intermittent hypoxia: New chambers give researchers dynamic and controlled O₂ environment to enhance research

Intermittent hypoxia (IH), also referred to as hypoxia-reoxygenation, is a condition where periods of normal tissue oxygen pressure (normoxia) cycle with periods of low tissue oxygen pressure (hypoxia). This alternating lack of oxygen is associated with various forms of

By |March 6th, 2019|Animal Models, Articles, Cancer Research, Hypoxia, Molecular, Mouse, Rat|

Investigating the role of metabolism in human induced pluripotent stem cell generation

This team of researchers in the Biology Department at Western University are investigating metabolic ways to increase efficiency of reprogramming adult cells to iPSCs. Embryonic stem cells are pluripotent, which means they can turn into any cell type found in the

By |February 21st, 2019|Articles, Cancer Research, Hypoxia, Lab Equipment, Molecular|

A Non-Invasive Method to Assess Coronary Flow Reserve

Coronary flow reserve (CFR) is a measure of the ability of the coronary arteries to increase blood flow to the myocardium via dilation during periods of stress.  CFR is reduced by age, as well as various disease states including