New technology video: The CondoCell
How can researchers ensure their cells grow at optimal conditions when incubator doors open and close at infrequent times on a daily basis? Is there an easy way to prevent contamination of key cell lines in a shared incubator?
In vivo tissue oxygenation: How do I know which method is best for my research?
There are a variety of ways that researchers today can measure oxygenation of tissue in vivo. Unfortunately, while a range of options do exist, choosing which technology to use to measure tissue oxygenation is often difficult, even to those who have
How modern hypoxia chambers and chemically defined media are changing the face of cancer research
Cancer micro-environments are essential in understanding cancer malignancy and can provide accurate insights into how therapies targeting tumors may respond. Looking into these micro-environments further, Scintica Instrumentation’s cellular oxygen expert, Justin Croft, teamed up with custom media specialist, Annie Cunningham, of InVitria
A Tale of Two Tubes: Exploring the Causes of Cardiovascular Disease from the Arteries to the Gut
The Integrative Cardiovascular Physiology laboratory at Colorado State University investigates the underlying causes of cardiovascular abnormalities in the settings of obesity and nutrient excess. Obese individuals are at an increased risk for developing cardiovascular disease (CVD)1. Prior to overt
Imaging Solutions for Preclinical Research: Imaging Modalities and Their Applications
With the ever-growing preclinical imaging field, it is difficult to know which imaging modality is ideal for your experiment. This brief overview aims to help researchers optimize their experiments and their funding by choosing ideal imaging modalities for their
Understanding oxygen sensing in cells: A video lecture by Dr. Peter Ratcliffe
The lecture “Elucidation of oxygen sensing pathways in human and animal cells; implications for Physiology” by esteemed professor Dr. Peter Ratcliffe of Oxford University delves into the topic of physoxia head on. Dr. Ratcliffe provides relevant and interesting data from
Investigating mechanisms driving acute kidney injury arising from heart surgery and sepsis
A team of researchers and clinicians at the Florey Institute of Neuroscience and Mental Health are investigating ways to reduce the incidence of kidney injury resulting from heart surgery and sepsis. Acute kidney injury is when our kidneys suddenly
Combating time and space issues in labs today: How a simple microscope is changing the way scientists do research
Combating time and space issue in labs todays: How a simple microscope is changing how scientists do research All researchers today, from grad students to principle investigators, are lacking 2 key factors that were widely available a generation
Cancer Biology and Magnetic Resonance Imaging (MRI): The Gold Standard of Soft Tissue Imaging
Magnetic resonance imaging (MRI) is a technique that utilizes magnetic fields to create images of the anatomy and the physiological processes within the body. Specifically, MRI, the gold standard in soft tissue imaging, offers researchers the ability to distinctly
A versatile tool for 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 vascular research
Vascular function can be assessed in vitro using a myograph. Benchtop wire myograph systems consist of an organ bath, mounting wire or prongs, a micrometer, and a force transducer and amplifier to measure tension development in the tissue. This
Is 1 tesla enough: How low-field MRI is permitting more preclinical researchers to utilize this gold standard technique than ever before
In my day to day interactions, I come across numerous researchers who are not able to fully utilize MRI systems as they would like or cannot see themselves using this technology even though it could immensely help their research.
The Importance of Cohousing During Telemetry Studies
Research animals must be housed under conditions that ensure their physiologic and behavioral needs are met. These conditions influence animal well-being and the quality of data obtained throughout a study. Facilities are often designed with many of these factors
PET/CT: Frequently Asked Questions
What is PET/CT Imaging? PET/CT imaging is the combination of two distinct imaging techniques. a What is PET Imaging? PET, or positron emission tomography, is a look at the metabolic or biochemical activity present in a given anatomical region
Cancer biology and High-Frequency Ultrasound: non-invasive identification, visualization, and quantification in a wide variety of preclinical tumor models
Ultrasound has become a widely used preclinical imaging modality that can be used to visualize a variety of internal structures within small animal models with high resolution (down to 30µm). This provides researchers with primary structural information in real-time
𝘐𝘯 𝘷𝘪𝘷𝘰 intermittent hypoxia: New chambers give researchers dynamic and controlled O₂ environment to enhance research
Intermittent hypoxia (IH), also referred to as hypoxia-reoxygenation, is a condition where periods of normal tissue oxygen pressure (normoxia) cycle with periods of low tissue oxygen pressure (hypoxia). This alternating lack of oxygen is associated with various forms of