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New Journal Article – Ultrasound-Induced Microbubble Cavitation via a Transcanal or Transcranial Approach Facilitates Inner Ear Drug Delivery

In a recent paper published in JCI Insight, researchers have demonstrated for the first time the feasibility of applying Ultrasound-induced Microbubble Cavitation via the external auditory canal as a technique to increase the efficiency of drug delivery to the

By |March 23rd, 2020|Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|

New Journal Article – Development of a Novel Superparamagnetic Nanoparticles to Quantify Nerve Density in Prostate Cancer and for Targeted Drug Delivery in the Same Model

In this journal article published in early February 2020 titled “Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer” in Science Advances, Huijuan You et al. discuss the development of their novel superparamagnetic iron

By |February 25th, 2020|Animal Models, Articles, Mouse, Rat, Telemetry, Tissue Oxygen|

In vivo tissue oxygenation: How do I know which method is best for my research?

There are a variety of ways that researchers today can measure oxygenation of tissue in vivo. Unfortunately, while a range of options do exist, choosing which technology to use to measure tissue oxygenation is often difficult, even to those who

How modern hypoxia chambers and chemically defined media are changing the face of cancer research

Cancer micro-environments are essential in understanding cancer malignancy and can provide accurate insights into how therapies targeting tumors may respond. Looking into these micro-environments further, Scintica Instrumentation’s cellular oxygen expert, Justin Croft, teamed up with custom media specialist, Annie Cunningham, of InVitria

By |October 15th, 2019|Articles, Cancer Research, Hypoxia, Molecular|

A Tale of Two Tubes: Exploring the Causes of Cardiovascular Disease from the Arteries to the Gut

The Integrative Cardiovascular Physiology laboratory at Colorado State University investigates the underlying causes of cardiovascular abnormalities in the settings of obesity and nutrient excess. Obese individuals are at an increased risk for developing cardiovascular disease (CVD)1. Prior to overt

Imaging Solutions for Preclinical Research: Imaging Modalities and Their Applications

With the ever-growing preclinical imaging field, it is difficult to know which imaging modality is ideal for your experiment. This brief overview aims to help researchers optimize their experiments and their funding by choosing ideal imaging modalities for their

Understanding oxygen sensing in cells: A video lecture by Dr. Peter Ratcliffe

The lecture “Elucidation of oxygen sensing pathways in human and animal cells; implications for Physiology” by esteemed professor Dr. Peter Ratcliffe of Oxford University delves into the topic of physoxia head on. Dr. Ratcliffe provides relevant and interesting data from

By |August 27th, 2019|Articles, Cancer Research, Hypoxia, Molecular, Physiology|

Investigating mechanisms driving acute kidney injury arising from heart surgery and sepsis

A team of researchers and clinicians at the Florey Institute of Neuroscience and Mental Health are investigating ways to reduce the incidence of kidney injury resulting from heart surgery and sepsis. Acute kidney injury is when our kidneys suddenly

Combating time and space issues in labs today: How a simple microscope is changing the way scientists do research

Combating time and space issue in labs todays: How a simple microscope is changing how scientists do research      All researchers today, from grad students to principle investigators, are lacking 2 key factors that were widely available a generation

By |June 10th, 2019|Articles, Cancer Research, Lab Equipment, Molecular, Physiology|

Cancer Biology and Magnetic Resonance Imaging (MRI): The Gold Standard of Soft Tissue Imaging

Magnetic resonance imaging (MRI) is a technique that utilizes magnetic fields to create images of the anatomy and the physiological processes within the body. Specifically, MRI, the gold standard in soft tissue imaging, offers researchers the ability to distinctly

A versatile tool for 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 vascular research

Vascular function can be assessed in vitro using a myograph. Benchtop wire myograph systems consist of an organ bath, mounting wire or prongs, a micrometer, and a force transducer and amplifier to measure tension development in the tissue. This

Is 1 tesla enough: How low-field MRI is permitting more preclinical researchers to utilize this gold standard technique than ever before

In my day to day interactions, I come across numerous researchers who are not able to fully utilize MRI systems as they would like or cannot see themselves using this technology even though it could immensely help their research.

By |May 6th, 2019|Animal Models, Articles, Cancer Research, Imaging, Molecular, Mouse, MRI, PET/CT, Rat|

The Importance of Cohousing During Telemetry Studies

Research animals must be housed under conditions that ensure their physiologic and behavioral needs are met.  These conditions influence animal well-being and the quality of data obtained throughout a study. Facilities are often designed with many of these factors