Mice are essential for a wide variety of research models, as they enable researchers to elucidate the pathogenesis of numerous diseases, and develop novel therapeutics. We offer laboratory solutions for anesthesia and surgical monitoring essentials, as well as more advanced tools such as telemetry, Doppler Flow Velocity systems, tissue oxygen and perfusion measurement systems, several blood pressure monitoring options, and a fluorescence endomicroscope to study a wide variety of disease models
Chronic monitoring of physiological parameters is made possible with telemetry. The mouse telemetry system from Indus Instruments enables ECG, temperature and activity recording in mice. The telemetry system from Kaha Sciences enables biopotential and activity recording in mice. Using telemetry enables long-term studies and reduces stress artifacts in data as animals do not require constant handling.
High Frequency Ultrasound
Ultrasound imaging is a non-invasive way to visualize a number of anatomical structures and disease processes in mice including, cardiovascular research, cancer biology, abdominal/anatomical targets, developmental biology, and opthamology. Image guided needle injection, 3D imaging, sonoporation, and shear wave elastography are all possible using this system.
There are multiple methods for assessing cardiovascular function in mouse models of cardiovascular disease. We offer a variety of solutions for in vivo and in vitro measurement, as well as options for chronic measurement in a variety of murine models. These systems are suitable for assessing a wide range of parameters including blood flow velocity, isolated heart function, ECG, blood pressure and more.
PET/CT Imaging is a non-invasive way to visualize metabolic or biochemical activity in the mouse. In mouse models, PET/CT imaging can now be an affordable way to make the most of models relevant in cancer biology, cardiovascular research, neurological research, and developmental biology. Customizable radioactive tracers allow for the investigation of any compound within the mouse anatomy.
MRI is the gold standard in soft tissue imaging. The M-seriesTM compact MRI system provides anatomical and morphological images to pre-clinical researcher focused on a variety of disease models including cancer, neurology, cardiovascular, inflammation, obesity & diabetes, as well as specific organ diseases and developmental biology.
Surgical monitoring is important for meeting IACUC guidelines and ensuring successful surgical procedures. The Rodent Surgical Monitor+ (RSM+) integrates a heating platform with a tablet for ECG, heart rate, respiration and temperature monitoring. Optional pulse oximetry and vascular/ventricular pressure modules increase functionality.
There are multiple techniques to assess vascular function in mouse models. Non-invasive pulse wave velocity can be quantified with the Doppler Flow Velocity System, whereas the OxyLite and OxyFlo systems are minimally invasive and quantify dissolved oxygen and tissue perfusion. Wire myographs and tissue baths are suitable for ex vivo assessment of vascular reactivity.
Anesthesia and ventilation
Anesthesia systems are laboratory essentials. UNO BV anesthesia systems are designed especially for low flows, incorporate active waste gas scavenging and have nose cones and induction boxes designed for mice. The ventilator features positive end-expiratory pressure settings, and is suitable for use in mice as small as twelve grams.
In vivo confocal microscopy
The FIVE2 (Vienvivo) from Optiscan is a miniaturized fluorescence endomicroscope that enables in vivo imaging in mouse models. Using patented Point Scanning Confocal Technology, the system captures full field of view images of cellular and sub-cellular structures. The system can be used to generate 3D visualizations through continuously variable depth control.
Blood pressure measurements in mice may be achieved invasively or non-invasively, depending on the nature of the study. With tail cuff probes, the NIBP systems enable blood pressure measurements in up to six mice simultaneously, and provides a pressure waveform. Alternatively, pressure catheters integrated with the RSM+ enable acute vascular or ventricular measurements coupled to vital signs.
We offer acute and chronic ECG measurement systems. For acute recordings, the Rodent Surgical Montior+ (RSM+) enables non-invasive ECG measurement streamed to a display tablet. For studies that require chronic ECG measurement, Kaha Sciences telemetry and Indus Instruments enable long-term recordings in conscious, free moving mice and can be integrated with a data acquisition system for analysis.
Ideal for mouse models, the VelO2x system was created to provide controlled and isolated environments. By simulating the conditions experienced within a diseased state, VelO2x allows researchers to better understand the impact that O2 levels have across various conditions.