Large animals including swine and ovine models, are particularly useful for translational research. These species have anatomic, physiological, genomic and immunologic similarities to humans that are sometimes lacking in rodent models. We offer solutions for assessing vascular function as well as in vivo confocal microscopy in large animal models.
Peripheral blood flow velocity
The Doppler Flow Velocity system can connect to surgically implanted silicone cuff probes, having a wide variety of diameters, which may be placed on specific vessels of interest. Repeated velocity measurements can be made at any time over the course of a longitudinal study.
Assessing vascular function in large animals can be achieved in ex vivo preparations with wire myographs and tissue baths. These systems assess vascular reactivity and smooth and striated muscle contractility using dissected tissue samples. For in vivo assessment of vascular function, the OxyLite/OxyFlo systems measure dissolved oxygen and tissue perfusion and offer implantable options for chronic studies.
In vivo confocal microscopy
The FIVE2 (ViewnVivo) is a miniaturized fluorescence endomicroscope on a small probe for in vivo imaging in large animal models. The system features patented Point Scanning Technology to capture full field of view images of cellular and sub-cellular structures. It has been used successfully in dog, horse, sheep and swine for imaging brain, vaginal tract, endometrium, and intestines.
High Frequency Ultrasound
Ultrasound imaging is a non-invasive way to visualize some of the superficial targets in large animals including opthamology applications. Image guided needle injection, 3D imaging, sonoporation, and shear wave elastography are all possible using this system.