In vitro research is foundational to all biomedical research. The advancements made in studying cells, bacteria, and viruses are often the first strides into understanding the in vivo condition. We offer a laboratory solution for providing a stable physiologically relevant environment to cells as well as a solution to count colonies in colony forming assays.
Ex vivo research is key to understanding specific organ and tissue function removed from other bodily stimuli. These conditions allow experimentation on an organism’s tissues under more controlled conditions than is possible in vivo. We currently offer many isolated heart, tissue, and vessel options.
Hypoxia Incubator and Workstation
For studies requiring a physiologically accurate atmosphere the HypoxyLab offers full control of O2, CO2, temperature and humidity. This ergonomically designed benchtop system is the only one of its kind to take measurements using the partial pressure of oxygen, making it the most reliable system for measuring
oxygen on the market.
For those performing spheroids or tumor forming assays the GelCount is an automated colony counter that saves researchers from the painstaking task of potentially counting thousands of wells manually. Besides saving researchers large amounts of time and effort the system also calculates various growth dynamics, like diameter, which is not possible though manual counts alone.
Live Cell Imaging
Live-cell imaging itself has become a desired and often necessary analytical tool in many cell biology laboratories that operate in the field of neurobiology, developmental biology, pharmacology. Currently live-cell imaging is often difficult, because it required large costly high-end devices that are difficult to operate. The CytoSMART Lux2 is a highly compact, easy to use, and affordable inverted microscope for bright-field live cell imaging so it can be used in every biological laboratory.
For cell researchers who have a standard CO2 incubator and want the option to perform studies controlling O2, there is the PhO2x Box. Perfect for short term hypoxia studies (where media does not need to be changed). The PhO2x Box grants researchers’ full control of O2 and CO2 while utilizing the temperature and humidity of the incubator.
OxyGenie is a low oxygen culture system for plant and cell biology. A miniaturized incubation platform, OxyGenie delivers researchers a small, portable and continuous physoxic (hypoxic) environment for short term physiological oxygen and temperature studies. OxyGenie is ideal for conducting high resolution microscopy or irradiation under physiological oxygen conditions
Luxury accommodation for cells. The CondoCell provides researchers 2 hypoxia options. 1) it allows them to take cells out of an existing hypoxia chamber and keeps them under those conditions for up to 20 mins and 2) an oxygen purging unit allows for a condo to be quickly purged of O2 for short term hypoxia studies.
The histology insert enables high-throughput, high resolution, 3D imaging of fixed samples. These images may be used for toxicology studies to help detect, localize, and quantify lesions within an organ sample. The histology insert expands the functionality of either the M3 or the M7 systems from Aspect Imaging.
The modular tissue bath system is suitable for use with smooth or striated muscle samples. Tissue and vessel ring holders enable the study of vessel rings and muscle tissue samples, adding to the versatility of the system. Force/displacement sensors quantify tissue reactivity, and the system can be coupled to a data acquisition system for data analysis.
Isolated Heart Systems
Isolated heart perfusion systems are ideal for ex vivo assessment of cardiac function. We offer gravitational, pump-controlled and compact systems for small animals. These systems can be configured as the Janicki-type Langendorff, where the heart is perfused through the aorta and the backward pressure forces flow into the coronary vessels, or the Neely-type working heart model.
The small vessel wire myograph system enables ex vivo assessment of vascular reactivity. The system is suitable for pharmacological studies of dissected vascular rings. The measuring unit is removable, and can be used with a microscope to make mounting vessel rings easier. An isometric tension sensor quantifies vascular contraction and relaxation.