In vitro research is foundational to all biomedical research. The advancements made in studying cells, bacteria, and viruses are often the first strides into understanding the in vivo condition. We offer a laboratory solution for providing a stable physiologically relevant environment to cells as well as a solution to count colonies in colony forming assays.
Ex vivo research is key to understanding specific organ and tissue function removed from other bodily stimuli. These conditions allow experimentation on an organism’s tissues under more controlled conditions than is possible in vivo. We currently offer many isolated heart, tissue, and vessel options.
Hypoxia Incubator and Workstation
For studies requiring a physiologically accurate atmosphere the HypoxyLab offers full control of O2, CO2, temperature and humidity. This ergonomically designed benchtop system is the only one of its kind to take measurements using the partial pressure of oxygen, making it the most reliable system for measuring
oxygen on the market.
For those performing spheroids or tumor forming assays the GelCount is an automated colony counter that saves researchers from the painstaking task of potentially counting thousands of wells manually. Besides saving researchers large amounts of time and effort the system also calculates various growth dynamics, like diameter, which is not possible though manual counts alone.
The histology insert enables high-throughput, high resolution, 3D imaging of fixed samples. These images may be used for toxicology studies to help detect, localize, and quantify lesions within an organ sample. The histology insert expands the functionality of either the M3 or the M7 systems from Aspect Imaging.
The modular tissue bath system is suitable for use with smooth or striated muscle samples. Tissue and vessel ring holders enable the study of vessel rings and muscle tissue samples, adding to the versatility of the system. Force/displacement sensors quantify tissue reactivity, and the system can be coupled to a data acquisition system for data analysis.
Isolated Heart Systems
Isolated heart perfusion systems are ideal for ex vivo assessment of cardiac function. We offer gravitational, pump-controlled and compact systems for small animals. These systems can be configured as the Janicki-type Langendorff, where the heart is perfused through the aorta and the backward pressure forces flow into the coronary vessels, or the Neely-type working heart model.
The small vessel wire myograph system enables ex vivo assessment of vascular reactivity. The system is suitable for pharmacological studies of dissected vascular rings. The measuring unit is removable, and can be used with a microscope to make mounting vessel rings easier. An isometric tension sensor quantifies vascular contraction and relaxation.