Overview: Learning objectives: How to perform neonatal model of transverse aortic constriction (nTAC) to induce pressure overload in neonatal mice? How to confirm the surgery using Doppler Flow Velocity measurements? How to confirm the surgery and assess the outcome using echocardiography? What is the outcome of induced pressure overload at P1 vs P7?
Introduction The study of vascular function is central to understanding almost every aspect of physiology, pathophysiology and pharmacology since it is the vasculature that perfuses and maintains the entire body. Diseases such as hypertension, diabetes and arteriosclerosis, and even normal processes such as aging, directly impact vascular structure and function, so it is of
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Overview: Key topics covered during this webinar included: Evaluating cardiac contractility using mean or peak aortic acceleration Investigating cardiac relaxation using mitral peak early velocity to peak atrial velocity ratio Interpreting myocardial perfusion capacity through coronary flow reserve at baseline and with disease or other conditions How Doppler Flow Velocity measurements can be
Join us LIVE for a hands-on demonstration of the Doppler Flow Velocity System. You will learn: Measurement for Cardiac systolic and diastolic function Serial measurements in response to interventions Severity of transverse aortic constriction (TAC) Coronary flow distribution Hyperemic velocity responses Pulse Wave Velocity from two aortic locations simultaneously New
Chronic blood pressure recordings from the abdominal aorta are commonplace in cardiovascular physiology, however the surgical implantation of catheters can be challenging. This webinar provided an overview of the surgical protocol that we recommend when implanting Kaha Sciences blood pressure telemeters. We also discussed some simple strategies to avoid common problems and the
Aging sharply increases the risk of cardiovascular disease, the leading cause of death in the United States. Even in individuals without overt cardiovascular disease, aging is associated with increased prevalence of cardiac hypertrophy, impaired diastolic function and reduced myocardial performance. Diastolic dysfunction is a common contributor to heart failure with preserved ejection fraction (HFpEF),
Carbon paste electrodes connected to a potentiostat have been shown to provide stable measurement of tissue oxygen levels in vivo. Now wireless telemetry from Kaha Sciences allows the chronic long-term measurement of tissue oxygen in rats living in their home cages. This webinar discussed how tissue oxygen measurements are made using carbon paste electrodes, how
Diabetes is a devastating disease affecting millions worldwide. Vascular complications are a major cause of morbidity and mortality in the diabetic population. Although much effort has been placed in examining mechanisms of endothelial dysfunction in diabetes, vascular smooth muscle complications are understudied. The L-type Ca2+ channel CaV1.2 plays key roles in vascular smooth muscle
Telemetry allows the long-term collection of data over days, weeks or months from animals in their home cages. Performing chronic studies presents a number of opportunities in terms of experimental design but also results in the collection of very large data sets. Large data sets come with challenges for the collection and analysis of
