Vascular function can be assessed in vitro using a myograph. Benchtop wire myograph systems consist of an organ bath, mounting wire or prongs, a micrometer, and a force transducer and amplifier to measure tension development in the tissue. This simple set-up is used in many fields of research, including pharmacology and vascular physiology. In
Research animals must be housed under conditions that ensure their physiologic and behavioral needs are met.Β These conditions influence animal well-being and the quality of data obtained throughout a study. Facilities are often designed with many of these factors in mind, including temperature and humidity control, lighting, noise and vibration.Β However, there are other
This free webinar hosted by Scintica Instrumentation introduced participants to some of the basics of high frequency ultrasound imaging and reviewed the most common preclinical research applications for this exciting technology. Our presenter, Ms. Tonya Coulthard, discussed the basic principles of ultrasound imaging, presented sample images from various organs and tissues as
This free webinar hosted by Scintica Instrumentation reviewed with the viewer the importance of monitoring their surgical outcomes, specifically following transverse aortic constriction (TAC) Join Tonya Coulthard as she discussed some background information about the TAC surgery, variability in the surgical outcomes and how to monitor those, as well as the
Coronary flow reserve (CFR) is a measure of the ability of the coronary arteries to increase blood flow to the myocardium via dilation during periods of stress.Β CFR is reduced by age, as well as various disease states including coronary artery disease.Β Given the small size and significant branching of these arteries, traditional methods
These videos summarize common techniques for assessing cardiac function using the Doppler Flow Velocity System. Fill out the form below with your name and email address to get access to these resources. Pulse Wave Velocity Coronary Flow Transverse Aortic Constriction
Chronic congestive heart failure, more commonly referred to as heart failure (HF), is a multifactorial cardiac disease which can affect the heart both structurally and/or functionally thereby impairing its ability to properly fill and eject blood from the ventricles. It is one of the leading causes of death with increasing incidence and prevalence rates,
The capability to precisely and non-invasively measure the systolic and diastolic blood pressure, on top of heart rate and other blood flow parameters in rodents, can be of great clinical value to researchers. The non-invasive rat and mouse blood pressure measurement consists of using a tail-cuff placed on the tail to occlude blood flow.
Dr. Anil Reddy discusses how to use noninvasive blood flow velocity measurements to quantify cardiac contractility as a surrogate to +dP/dtmax. Invasive measurement of left ventricular pressure is considered the gold standard for evaluating cardiac contractility and relaxation in preclinical research. Β However, studying disease progression in the same subject over time is not possible,
Join Dr. Tim Hacker for a discussion on experimental design, strategy, technology, common challenges and best-practices associated with planning long-term, chronic models of cardiovascular disease in rodents. Watch on Demand Creating chronic, long-term models of heart disease in rodents continues to be a fundamental
