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Cardiac Function

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A versatile tool for π˜ͺ𝘯 𝘷π˜ͺ𝘡𝘳𝘰 vascular research

Vascular function can be assessed in vitro using a myograph. Benchtop wire myograph systems consist of an organ bath, mounting wire or prongs, a micrometer, and a force transducer and amplifier to measure tension development in the tissue. This simple set-up is used in many fields of research, including pharmacology and vascular physiology. In

By |2019-05-15T12:48:53-04:00May 14th, 2019|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Lab Equipment, Mouse, Physiology, Rat|Comments Off on A versatile tool for π˜ͺ𝘯 𝘷π˜ͺ𝘡𝘳𝘰 vascular research

The Importance of Cohousing During Telemetry Studies

Research animals must be housed under conditions that ensure their physiologic and behavioral needs are met.Β  These conditions influence animal well-being and the quality of data obtained throughout a study. Facilities are often designed with many of these factors in mind, including temperature and humidity control, lighting, noise and vibration.Β  However, there are other

By |2019-04-29T11:39:20-04:00April 29th, 2019|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Lab Equipment, Mouse, Physiology, Rat, Telemetry|Comments Off on The Importance of Cohousing During Telemetry Studies

Webinar: How high frequency ultrasound imaging is supporting preclinical research applications

This free webinar hosted by Scintica Instrumentation introduced participants to some of the basics of high frequency ultrasound imaging and reviewed the most common preclinical research applications for this exciting technology. Our presenter, Ms. Tonya Coulthard, discussed the basic principles of ultrasound imaging, presented sample images from various organs and tissues as

By |2019-04-26T13:40:48-04:00February 25th, 2019|Categories: Cancer Research, Cardiac Function, Cardiovascular Research, Event, Imaging, Physiology, Ultrasound, Webinar|Comments Off on Webinar: How high frequency ultrasound imaging is supporting preclinical research applications

Webinar: Transverse Aortic Constriction: The Importance of Monitoring Surgical Outcomes

This free webinar hosted by Scintica Instrumentation reviewed with the viewer the importance of monitoring their surgical outcomes, specifically following transverse aortic constriction (TAC) Join Tonya Coulthard as she discussed some background information about the TAC surgery, variability in the surgical outcomes and how to monitor those, as well as the

By |2019-06-04T16:34:18-04:00February 7th, 2019|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Event, Mouse, Physiology, Rat, Transverse Aortic Constriction, Webinar|Comments Off on Webinar: Transverse Aortic Constriction: The Importance of Monitoring Surgical Outcomes

A Non-Invasive Method to Assess Coronary Flow Reserve

Coronary flow reserve (CFR) is a measure of the ability of the coronary arteries to increase blood flow to the myocardium via dilation during periods of stress.Β  CFR is reduced by age, as well as various disease states including coronary artery disease.Β  Given the small size and significant branching of these arteries, traditional methods

By |2019-03-01T15:29:35-04:00January 17th, 2019|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Fish, Physiology, Rat|Comments Off on A Non-Invasive Method to Assess Coronary Flow Reserve

Doppler Flow Velocity Video Resources

These videos summarize common techniques for assessing cardiac function using the Doppler Flow Velocity System. Fill out the form below with your name and email address to get access to these resources. Pulse Wave Velocity Coronary Flow Transverse Aortic Constriction

By |2019-03-06T11:11:43-04:00January 15th, 2019|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Fish, Mouse, Rat, Transverse Aortic Constriction|Comments Off on Doppler Flow Velocity Video Resources

Transverse Aortic Constriction (TAC): Why, how and the outcome as it relates to pressure overload-induced cardiac hypertrophy and/or heart failure

Chronic congestive heart failure, more commonly referred to as heart failure (HF), is a multifactorial cardiac disease which can affect the heart both structurally and/or functionally thereby impairing its ability to properly fill and eject blood from the ventricles. It is one of the leading causes of death with increasing incidence and prevalence rates,

By |2019-05-29T09:55:49-04:00December 7th, 2018|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Mouse, Physiology, Transverse Aortic Constriction|Comments Off on Transverse Aortic Constriction (TAC): Why, how and the outcome as it relates to pressure overload-induced cardiac hypertrophy and/or heart failure

WEBINAR: A Noninvasive Alternative to +dP/dtmax: Peak Aortic Blood Acceleration

Dr. Anil Reddy discusses how to use noninvasive blood flow velocity measurements to quantify cardiac contractility as a surrogate to +dP/dtmax. Invasive measurement of left ventricular pressure is considered the gold standard for evaluating cardiac contractility and relaxation in preclinical research. Β However, studying disease progression in the same subject over time is not possible,

By |2018-11-07T10:35:58-04:00November 7th, 2018|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Event, Mouse, Physiology, Rat, Webinar|Comments Off on WEBINAR: A Noninvasive Alternative to +dP/dtmax: Peak Aortic Blood Acceleration

Cardiac Capacity and Thermal Performance: an examination of cardiovascular development in Atlantic salmon

This team of researchers in the Biology Department at Western University are investigating ways to reintroduce Atlantic salmon to the Great Lakes, specifically Lake Ontario. Hatchery stocking programs are a major tool used to improve recreational fishing opportunities. They are also often used to help supplement at-risk populations of fish in vulnerable habitats. One

By |2019-03-01T15:32:53-04:00October 30th, 2018|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Fish, Physiology|Comments Off on Cardiac Capacity and Thermal Performance: an examination of cardiovascular development in Atlantic salmon

Endothelial Dysfunction and Arterial Stiffness: Elucidating the mechanisms of the underlying pathophysiological changes

Cardiovascular changes associated with aging result in significant morbidity and mortality worldwide. The research community invests a tremendous amount of effort in investigating endothelial dysfunction and arterial stiffness. By measuring both tissue-level and system-level physiology the mechanisms surrounding the pathological changes associated with aging may be elucidated. In addition to aging,

By |2019-03-01T15:33:48-04:00October 1st, 2018|Categories: Articles, Cardiac Function, Cardiovascular Research, Mouse, Physiology, Rat|Comments Off on Endothelial Dysfunction and Arterial Stiffness: Elucidating the mechanisms of the underlying pathophysiological changes