Circadian clocks are present in most cells of the body and act to coordinate human’s daily physiology and behavior with the environment. This is important as circadian misalignment between the bodies clock and the environment has been connected to various pathologies. Here, a group from Israel has shown that circadian misalignment can also occur
There have been a number of published reports recently suggesting a substantial amount of cancer related studies published in high-impact scientific journals could not be reproduced outside of their originator laboratories. These discoveries are remarkably problematic as many of the drugs screened are being developed past the preclinical stage, into human testing and
June 9, 2020 11:00 - 11:45 AM (EDT) (UTC−04:00) This free webinar hosted by Scintica Instrumentation will provide researchers with an overview on the effects of intermittent hypoxia in vivo. The talk will define intermittent hypoxia and provide some relevant research in this growing area. Further, the discussion will focus on issues
The survival of tissues and organs relies on an adequate supply of oxygen. Tissue oxygen tension (ptiO2) provides a direct measurement of the balance between oxygen supply (by the blood) and metabolic oxygen consumption (by the tissue), i.e. a readout of oxygen availability at the cellular level. On Demand
This free webinar hosted by Scintica Instrumentation provided researchers with an overview on the effects of oxygen during in vitro cell culturing. Further, the discussion focused on how to accurately determine and regulate the O2 levels during experiments. Last,we took researchers through our extensive list of hypoxia/physoxia options and guide them down the
How can researchers ensure their cells grow at optimal conditions when incubator doors open and close at infrequent times on a daily basis? Is there an easy way to prevent contamination of key cell lines in a shared incubator? Want to keep cells at optimal conditions even outside of an incubator (CO2 or Tri-gas)? The
Cancer micro-environments are essential in understanding cancer malignancy and can provide accurate insights into how therapies targeting tumors may respond. Looking into these micro-environments further, Scintica Instrumentation’s cellular oxygen expert, Justin Croft, teamed up with custom media specialist, Annie Cunningham, of InVitria to publish the article “How modern hypoxia chambers and chemically defined media are changing the
The lecture “Elucidation of oxygen sensing pathways in human and animal cells; implications for Physiology” by esteemed professor Dr. Peter Ratcliffe of Oxford University delves into the topic of physoxia head on. Dr. Ratcliffe provides relevant and interesting data from across his career’s work in solving mechanisms by which cells sense and signal hypoxia. The
Intermittent hypoxia (IH), also referred to as hypoxia-reoxygenation, is a condition where periods of normal tissue oxygen pressure (normoxia) cycle with periods of low tissue oxygen pressure (hypoxia). This alternating lack of oxygen is associated with various forms of the respiratory illness, sleep apnea. Those afflicted with sleep apnea can see oxygen fluctuate dramatically
Scintica Instrumentation Inc. is excited to announce its recent distribution agreement for the Baker Ruskinn preclinical VelO₂x hypoxia chamber for scientific research. The VelO₂x system has been engineered to provide an isolated and highly controlled oxygen environment to help researchers better understand how O₂ levels affect various conditions such as sleep apnea, systemic hypertension,
