Hypoxia Archives - Scintica Instrumentation

How modern hypoxia chambers and chemically defined media are changing the face of cancer research

How modern hypoxia chambers and chemically defined media are changing the face of cancer research

Cancer micro-environments are essential in understanding cancer malignancy and can provide accurate insights into how therapies targeting tumors may respond. Looking into these micro-environments further, Scintica Instrumentation’s cellular oxygen expert, Justin Croft, teamed up with custom media specialist, Annie Cunningham, of InVitria to publish the article “How modern hypoxia chambers and chemically defined media are changing the

By Justin Croft|2019-10-15T14:33:31-04:00October 15th, 2019|Categories: Articles, Cancer Research, Hypoxia, Molecular|Comments Off

Understanding oxygen sensing in cells: A video lecture by Dr. Peter Ratcliffe

Understanding oxygen sensing in cells: A video lecture by Dr. Peter Ratcliffe

The lecture “Elucidation of oxygen sensing pathways in human and animal cells; implications for Physiology” by esteemed professor Dr. Peter Ratcliffe of Oxford University delves into the topic of physoxia head on. Dr. Ratcliffe provides relevant and interesting data from across his career’s work in solving mechanisms by which cells sense and signal hypoxia. The

By Justin Croft|2019-08-28T10:28:41-04:00August 27th, 2019|Categories: Articles, Cancer Research, Hypoxia, Molecular, Physiology|Comments Off

𝘐𝘯 𝘷𝘪𝘷𝘰 intermittent hypoxia: New chambers give researchers dynamic and controlled O₂ environment to enhance research

𝘐𝘯 𝘷𝘪𝘷𝘰 intermittent hypoxia: New chambers give researchers dynamic and controlled O₂ environment to enhance research

Intermittent hypoxia (IH), also referred to as hypoxia-reoxygenation, is a condition where periods of normal tissue oxygen pressure (normoxia) cycle with periods of low tissue oxygen pressure (hypoxia). This alternating lack of oxygen is associated with various forms of the respiratory illness, sleep apnea. Those afflicted with sleep apnea can see oxygen fluctuate dramatically

By Justin Croft|2019-03-06T12:29:31-04:00March 6th, 2019|Categories: Animal Models, Articles, Cancer Research, Hypoxia, Molecular, Mouse, Rat|Comments Off

Scintica Instrumentation to distribute the VelO₂x hypoxia chamber system from Baker Ruskinn

Scintica Instrumentation to distribute the VelO₂x hypoxia chamber system from Baker Ruskinn

Scintica Instrumentation Inc. is excited to announce its recent distribution agreement for the Baker Ruskinn preclinical VelO₂x hypoxia chamber for scientific research. The VelO₂x system has been engineered to provide an isolated and highly controlled oxygen environment to help researchers better understand how O₂ levels affect various conditions such as sleep apnea, systemic hypertension,

By Sam Sandoval|2019-03-06T13:52:16-04:00March 5th, 2019|Categories: Event, Hypoxia, News|Comments Off

Investigating the role of metabolism in human induced pluripotent stem cell generation

Investigating the role of metabolism in human induced pluripotent stem cell generation

This team of researchers in the Biology Department at Western University are investigating metabolic ways to increase efficiency of reprogramming adult cells to iPSCs. Embryonic stem cells are pluripotent, which means they can turn into any cell type found in the adult body and are therefore critical for human development1. Stem cells show great promise in

By Justin Croft|2019-03-01T15:28:47-04:00February 21st, 2019|Categories: Articles, Cancer Research, Hypoxia, Lab Equipment, Molecular|Comments Off

WEBINAR: What is hyperoxia, normoxia and hypoxia to cells: Why researchers should care about environmental oxygen and how it influences results

WEBINAR: What is hyperoxia, normoxia and hypoxia to cells: Why researchers should care about environmental oxygen and how it influences results

What oxygen levels are you using in your cellular research? Are your cells under hyperoxia, normoxia, hypoxia, or are you unsure? This free webinar hosted by Scintica Instrumentation provided our audience with an overview on the effects of oxygen during in vitro cell culturing. Further, the discussion focused on how to

By Nicky Pansters|2019-09-24T12:17:02-04:00December 21st, 2018|Categories: Cancer Research, Event, Hypoxia, Molecular, Webinar|Comments Off

Normoxia isn’t normal: Conventional incubators generate more questions than they answer

Normoxia isn’t normal: Conventional incubators generate more questions than they answer

Since the first CO2 incubators were made commercially available in the late 1960’s they have become a staple for researchers to grow and maintain cells in vitro. These chambers have been highly effective for this task; however, they do not take into account one significant factor - oxygen. Currently, there is a push from

By Justin Croft|2019-03-01T15:30:55-04:00November 26th, 2018|Categories: Articles, Cancer Research, Hypoxia, Lab Equipment, Molecular|Comments Off

Bringing hypoxia chambers into the 21st century: Making a case for absolute measurements

Bringing hypoxia chambers into the 21st century: Making a case for absolute measurements

In the last year, I’ve spoken to countless hypoxia researchers in person, at conferences, and over the phone. When I reach out to these people the one question I always ask is “in what units does your current chamber report measured oxygen content?” to which I almost always get a resounding answer of percentage

By Justin Croft|2019-03-01T15:33:00-04:00October 29th, 2018|Categories: Articles, Cancer Research, Hypoxia, Molecular|0 Comments

Important questions to consider when doing hypoxia research

Important questions to consider when doing hypoxia research

The review article “Frequently asked questions in hypoxia research” by Wenger et al. covers several issues every researcher performing In vivo or In vitro hypoxia-based research should think about before performing their studies. This article is meant to help those in the early stages of attempting hypoxic studies. It should also be useful to

By Justin Croft|2019-04-09T15:44:59-04:00September 26th, 2018|Categories: Articles, Hypoxia, Molecular, Physiology|Comments Off