Scientists out of Vanderbilt and the University of North Carolina at Chapel Hill have established two separate organoid lines derived from active Kras-induced mouse stomach tissue. These organoid lines embody an in vitro system displaying characteristics of abnormal cells within the tissue known as dysplasia. The study published in Nature Communications provides further insights
Programmed death ligand 1 (PD-L1) is the principal ligand of the programmed death one (PD-1) receptor and is essential in the development of immune tolerance and prevention of autoimmunity. Unfortunately, PD-L1 is also expressed in many tumour types which is instrumental in allowing cancer cells to evade immune recognition. Immunohistochemistry may be used to
Externally nothing was altered. The HypoxyLab continues to be a well designed, compact, and ergonomically friendly hypoxia workstation perfect for any lab bench. All the changes themselves revolve around a complete redesign of the inner turret which houses the gas distribution system, temperature regulation, various sensors and HEPA filter. What does this mean for
Overview: In this free webinar, CytoSMART has partnered with prominent labs from academia to facilitate an open discussion about the use of live-cell imaging for viability analysis. We will be covering: The use of both brightfield and fluorescent live-cell imaging to analyze the effect of a treatment on cell viability. How cell viability
Introduction Dual Energy X-Ray Absorptiometry (DXA/DEXA) is a technique used to assess body composition, providing measurements of bone mineral density and content along with lean and fat mass measurements. In essence, each pixel on the x-ray image is assigned to one of three categories – bone, fat, or lean mass. Clinical DXA DXA is
Whether detecting DNA, RNA, or proteins, it is challenging to find many biological publications today not using some form of gel and/or western blot documentation in their findings. While the imaging of high amounts of nucleic acids or proteins should not ever be a challenge for a documentation system, researchers more often find themselves needing to resolve small amounts of these end products. For these researchers and these types of experiments, high-end optics with intelligent analysis
What is live cell imaging and what sets it apart? Live cell imaging is an umbrella term that refers to a plethora of methods that use time-lapse microscopy to observe, track, and quantify dynamic processes in cells or subcellular systems. This type of imaging is vital for a variety of fields including cell biology, developmental biology,
There have been a number of published reports recently suggesting a substantial amount of cancer related studies published in high-impact scientific journals could not be reproduced outside of their originator laboratories. These discoveries are remarkably problematic as many of the drugs screened are being developed past the preclinical stage, into human testing
In this webinar Dr. Robert Lenkinski, Professor at UT Southwestern, discussed his work using the compact 1T preclinical magnetic resonance imaging (MRI) scanner from Aspect Imaging. The work presented is from his time at both Harvard Medical School and UT Southwestern, as he purchased the same system when working at both institutions.
June 9, 2020 11:00 - 11:45 AM (EDT) (UTC−04:00) This free webinar hosted by Scintica Instrumentation will provide researchers with an overview on the effects of intermittent hypoxia in vivo. The talk will define intermittent hypoxia and provide some relevant research in this growing area. Further, the discussion will focus on issues
