The mechanisms involved in the progression of heart failure includes cardiomyocyte death, initiation of the inflammatory response, and subsequent formation of a fibrotic scar. For this reason, diverse experimental models, such as cultured cardiac cells, isolated hearts, and animal models, have been created to mimic human myocardial infarction and heart failure. In a 2012
This free webinar hosted by Scintica Instrumentation provides an overview of different rodent anesthesia options and highlights the importance of rodent surgical monitoring and user safety. Topics discussed include: the benefits of inhalation versus injectable anesthesia, the physiological side effects of anesthesia, increasing Institutional Animal Care and Use Committee (IACUC) requirements,
Why is surgical monitoring important? Updates found in the 8th edition of the National Research Council’s Guide for the Care and Use of Laboratory Animals highlight the importance of thermoregulation, and vital signs monitoring during surgical procedures. This updated guide has led to increasing Institutional Animal Care and Use Committee (IACUC) requirements for surgical
Clinical advancements in the diagnosis and treatment of cardiovascular disease stem from essential pre-clinical research. Small animal models, such as rodents, are used to study the pathophysiology of disease as well as the effects of pharmacologic interventions. In some cases, surgical methods are required to generate a disease model, such as transverse aortic constriction
Let's talk lab safety Anesthesia is essential in small animal research. Many different types of anesthetics are available, and understanding the associated benefits and risks helps to ensure animal and user safety. Certain procedures may necessitate injectable anesthesia, however, there are multiple advantages to using inhalants whenever possible. With injectables, difficulty choosing
