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In vivo tissue oxygenation: How do I know which method is best for my research?

There are a variety of ways that researchers today can measure oxygenation of tissue in vivo. Unfortunately, while a range of options do exist, choosing which technology to use to measure tissue oxygenation is often difficult, even to those who have years of experience in the field. Here, we cover the four most prominent ways researchers

By |2019-10-18T17:12:50-04:00October 18th, 2019|Categories: Animal Models, Articles, Micro-Vascular Flow, Mouse, Physiology, Rat, Telemetry, Tissue Oxygen|Comments Off on In vivo tissue oxygenation: How do I know which method is best for my research?

How modern hypoxia chambers and chemically defined media are changing the face of cancer research

Cancer micro-environments are essential in understanding cancer malignancy and can provide accurate insights into how therapies targeting tumors may respond. Looking into these micro-environments further, Scintica Instrumentation’s cellular oxygen expert, Justin Croft, teamed up with custom media specialist, Annie Cunningham, of InVitria to publish the article “How modern hypoxia chambers and chemically defined media are changing the

By |2019-10-15T14:33:31-04:00October 15th, 2019|Categories: Articles, Cancer Research, Hypoxia, Molecular|Comments Off on How modern hypoxia chambers and chemically defined media are changing the face of cancer research

A Tale of Two Tubes: Exploring the Causes of Cardiovascular Disease from the Arteries to the Gut

The Integrative Cardiovascular Physiology laboratory at Colorado State University investigates the underlying causes of cardiovascular abnormalities in the settings of obesity and nutrient excess. Obese individuals are at an increased risk for developing cardiovascular disease (CVD)1. Prior to overt clinical manifestation of CVD, the arteries of obese individuals (and other at-risk populations) begin to

By |2019-10-15T14:26:38-04:00September 11th, 2019|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Fish, Mouse, Physiology, Rat|Comments Off on A Tale of Two Tubes: Exploring the Causes of Cardiovascular Disease from the Arteries to the Gut

Imaging Solutions for Preclinical Research: Imaging Modalities and Their Applications

With the ever-growing preclinical imaging field, it is difficult to know which imaging modality is ideal for your experiment. This brief overview aims to help researchers optimize their experiments and their funding by choosing ideal imaging modalities for their prospective publications.  Modalities discussed include: Magnetic Resonance Imaging (MRI) Positron Emission Tomography (PET) Computed Tomography

By |2019-08-28T10:28:24-04:00August 27th, 2019|Categories: Animal Models, Articles, Cancer Research, Cardiovascular Research, Confocal, Fish, Imaging, Mouse, MRI, PET/CT, Physiology, Rat, Ultrasound|Comments Off on Imaging Solutions for Preclinical Research: Imaging Modalities and Their Applications

Understanding oxygen sensing in cells: A video lecture by Dr. Peter Ratcliffe

The lecture “Elucidation of oxygen sensing pathways in human and animal cells; implications for Physiology” by esteemed professor Dr. Peter Ratcliffe of Oxford University delves into the topic of physoxia head on. Dr. Ratcliffe provides relevant and interesting data from across his career’s work in solving mechanisms by which cells sense and signal hypoxia. The

By |2019-08-28T10:28:41-04:00August 27th, 2019|Categories: Articles, Cancer Research, Hypoxia, Molecular, Physiology|Comments Off on Understanding oxygen sensing in cells: A video lecture by Dr. Peter Ratcliffe

Investigating mechanisms driving acute kidney injury arising from heart surgery and sepsis

A team of researchers and clinicians at the Florey Institute of Neuroscience and Mental Health are investigating ways to reduce the incidence of kidney injury resulting from heart surgery and sepsis. Acute kidney injury is when our kidneys suddenly stop working. This happens in up to 30% of patients after heart surgery. Up to

By |2019-07-12T15:48:24-04:00July 12th, 2019|Categories: Animal Models, Articles, Micro-Vascular Flow, Mouse, Physiology, Rat, Tissue Oxygen|Comments Off on Investigating mechanisms driving acute kidney injury arising from heart surgery and sepsis

Combating time and space issues in labs today: How a simple microscope is changing the way scientists do research

Combating time and space issue in labs todays: How a simple microscope is changing how scientists do research      All researchers today, from grad students to principle investigators, are lacking 2 key factors that were widely available a generation ago. Today, both overall time and lab space have become a commodity in the research

By |2019-07-12T15:25:51-04:00June 10th, 2019|Categories: Articles, Cancer Research, Lab Equipment, Molecular, Physiology|Comments Off on Combating time and space issues in labs today: How a simple microscope is changing the way scientists do research

Cancer Biology and Magnetic Resonance Imaging (MRI): The Gold Standard of Soft Tissue Imaging

Magnetic resonance imaging (MRI) is a technique that utilizes magnetic fields to create images of the anatomy and the physiological processes within the body. Specifically, MRI, the gold standard in soft tissue imaging, offers researchers the ability to distinctly contrast between normal and pathological tissue. When it comes to the strengths of MRI in

By |2019-05-21T17:12:43-04:00May 21st, 2019|Categories: Animal Models, Articles, Cancer Research, Imaging, Molecular, Mouse, MRI, PET/CT, Rat|Tags: , , , , , , , , , , , , , , , , , , , , |Comments Off on Cancer Biology and Magnetic Resonance Imaging (MRI): The Gold Standard of Soft Tissue Imaging

A versatile tool for 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 vascular research

Vascular function can be assessed in vitro using a myograph. Benchtop wire myograph systems consist of an organ bath, mounting wire or prongs, a micrometer, and a force transducer and amplifier to measure tension development in the tissue. This simple set-up is used in many fields of research, including pharmacology and vascular physiology. In

By |2019-05-15T12:48:53-04:00May 14th, 2019|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Lab Equipment, Mouse, Physiology, Rat|Comments Off on A versatile tool for 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 vascular research

Is 1 tesla enough: How low-field MRI is permitting more preclinical researchers to utilize this gold standard technique than ever before

In my day to day interactions, I come across numerous researchers who are not able to fully utilize MRI systems as they would like or cannot see themselves using this technology even though it could immensely help their research. The reasons for this are numerous but often fall into 1 of 3 categories. Price

By |2019-05-06T13:05:16-04:00May 6th, 2019|Categories: Animal Models, Articles, Cancer Research, Imaging, Molecular, Mouse, MRI, PET/CT, Rat|Comments Off on Is 1 tesla enough: How low-field MRI is permitting more preclinical researchers to utilize this gold standard technique than ever before