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New Article: Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach

Scientists out of Vanderbilt and the University of North Carolina at Chapel Hill have established two separate organoid lines derived from active Kras-induced mouse stomach tissue. These organoid lines embody an in vitro system displaying characteristics of abnormal cells within the tissue known as dysplasia. The study published in Nature Communications provides further insights

By |2021-02-01T16:46:30-05:00February 1st, 2021|Categories: Articles, Cancer Research, Lab Equipment, Molecular|Tags: |Comments Off on New Article: Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach

Development of [¹⁸F]FPy-WL12 as a PD-L1 Specific PET Imaging Peptide

Programmed death ligand 1 (PD-L1) is the principal ligand of the programmed death one (PD-1) receptor and is essential in the development of immune tolerance and prevention of autoimmunity. Unfortunately, PD-L1 is also expressed in many tumour types which is instrumental in allowing cancer cells to evade immune recognition. Immunohistochemistry may be used to

By |2021-02-03T10:44:58-05:00January 27th, 2021|Categories: Animal Models, Articles, Cancer Research, Imaging, Molecular, Mouse, PET/CT, Rat|Tags: |Comments Off on Development of [¹⁸F]FPy-WL12 as a PD-L1 Specific PET Imaging Peptide

New Year, New HypoxyLab: Big Changes Coming to the System in 2021

Externally nothing was altered. The HypoxyLab continues to be a well designed, compact, and ergonomically friendly hypoxia workstation perfect for any lab bench. All the changes themselves revolve around a complete redesign of the inner turret which houses the gas distribution system, temperature regulation, various sensors and HEPA filter. What does this mean for

By |2021-02-04T14:26:19-05:00January 25th, 2021|Categories: Articles, Cancer Research, Hypoxia, Lab Equipment, Molecular|Tags: |Comments Off on New Year, New HypoxyLab: Big Changes Coming to the System in 2021

Pressure Arteriography or Wire Myography? How to choose for your model.

Introduction The study of vascular function is central to understanding almost every aspect of physiology, pathophysiology and pharmacology since it is the vasculature that perfuses and maintains the entire body.  Diseases such as hypertension, diabetes and arteriosclerosis, and even normal processes such as aging, directly impact vascular structure and function, so it is of

By |2021-02-04T14:26:56-05:00January 21st, 2021|Categories: Articles, Cardiovascular Research, Physiology|Tags: |Comments Off on Pressure Arteriography or Wire Myography? How to choose for your model.

Dual Energy X-Ray Absorptiometry How Does it Work?

Introduction Dual Energy X-Ray Absorptiometry (DXA/DEXA) is a technique used to assess body composition, providing measurements of bone mineral density and content along with lean and fat mass measurements. In essence, each pixel on the x-ray image is assigned to one of three categories – bone, fat, or lean mass. Clinical DXA DXA is

By |2021-01-25T12:55:53-05:00December 22nd, 2020|Categories: Articles, Cancer Research, Imaging|Tags: |Comments Off on Dual Energy X-Ray Absorptiometry How Does it Work?

The New Benchmark: How Vilber optics are revolutionizing gel and blot imaging for researchers

Whether detecting DNA, RNA, or proteins, it is challenging to find many biological publications today not using some form of gel and/or western blot documentation in their findings. While the imaging of high amounts of nucleic acids or proteins should not ever be a challenge for a documentation system, researchers more often find themselves needing to resolve small amounts of these end products. For these researchers and these types of experiments, high-end optics with intelligent analysis

By |2021-02-05T12:04:11-05:00November 23rd, 2020|Categories: Articles, Cancer Research, Imaging, Molecular|Tags: |Comments Off on The New Benchmark: How Vilber optics are revolutionizing gel and blot imaging for researchers

Live cell imaging is making research easier and adding efficiency to labs under COVID-19 restrictions

What is live cell imaging and what sets it apart?  Live cell imaging is an umbrella term that refers to a plethora of methods that use time-lapse microscopy to observe, track, and quantify dynamic processes in cells or subcellular systems. This type of imaging is vital for a variety of fields including cell biology, developmental biology,

By |2021-02-05T12:08:35-05:00July 20th, 2020|Categories: Articles, Cancer Research, Imaging, Molecular|Tags: |Comments Off on Live cell imaging is making research easier and adding efficiency to labs under COVID-19 restrictions

Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis

Tumor hypoxia and aerobic glycolysis are well-known resistance factors for anticancer therapies. Most tumour cells are subject to conditions in which oxygen is not readily available, known as tumour hypoxia, due to abnormal vasculature. Effective radiotherapy relies on the creation of reactive oxygen species, therefore hypoxic tumors are radiation resistant. Further, both chemotherapy and

By |2021-02-08T13:00:13-05:00July 16th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, MRI, PET/CT, Rat|Tags: , |Comments Off on Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis

SimPET: A Preclinical PET Insert for Simultaneous PET/MR Imaging

Simultaneous Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) provides a unique non-invasive opportunity to image both the functional and structural characteristics of biological systems. PET imaging shows high-sensitivity to dynamic metabolic and functional processes through tracking of biomarkers in-vivo but lacks the resolution to resolve detailed anatomy. MRI produces exceptional soft-tissue contrast

By |2021-02-08T20:04:10-05:00July 16th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, MRI, PET/CT, Rat|Tags: , |Comments Off on SimPET: A Preclinical PET Insert for Simultaneous PET/MR Imaging

New Journal Article – Cell Proliferation Detected Using [18F]FLT PET/CT as an Early Marker of Abdominal Aortic Aaneurysm

Abdominal aortic aneurysm (AAA) is a localized dilatation of the abdominal aorta which shows limited symptomology prior to rupture. Once rupture occurs though, the results may be catastrophic leading to intense pain, loss of consciousness, and possibly death. Detection often occurs incidentally or through routine screening, and surgical intervention is generally limited to large

By |2021-02-08T23:13:19-05:00June 26th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: , |Comments Off on New Journal Article – Cell Proliferation Detected Using [18F]FLT PET/CT as an Early Marker of Abdominal Aortic Aaneurysm
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