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New Journal Article – Cell Proliferation Detected Using [18F]FLT PET/CT as an Early Marker of Abdominal Aortic Aaneurysm

Abdominal aortic aneurysm (AAA) is a localized dilatation of the abdominal aorta which shows limited symptomology prior to rupture. Once rupture occurs though, the results may be catastrophic leading to intense pain, loss of consciousness, and possibly death. Detection often occurs incidentally or through routine screening, and surgical intervention is generally limited to large

By |2020-06-26T14:20:38-04:00June 26th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: , |Comments Off on New Journal Article – Cell Proliferation Detected Using [18F]FLT PET/CT as an Early Marker of Abdominal Aortic Aaneurysm

Intermittent Hypoxia (OSA) and sustained hypoxia can prompt inter-tissue circadian clock misalignment

Circadian clocks are present in most cells of the body and act to coordinate human’s daily physiology and behavior with the environment. This is important as circadian misalignment between the bodies clock and the environment has been connected to various pathologies. Here, a group from Israel has shown that circadian misalignment can also occur

By |2020-06-18T10:29:16-04:00June 17th, 2020|Categories: Animal Models, Articles, Hypoxia, Molecular, Mouse, Rat|Tags: |Comments Off on Intermittent Hypoxia (OSA) and sustained hypoxia can prompt inter-tissue circadian clock misalignment

New Journal Article – Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

Circadian Rhythms lead to the coordination of a multitude of physiological, behavioural, and metabolic processes to the natural 24-hour periodicity of the earth’s rotation. In this paper from 2019 published in Molecular Metabolism, researchers demonstrated the important of an overall synchronized circadian clock network to maintain metabolic homeostasis. In mammals, many metabolic processes are

By |2020-06-03T12:56:00-04:00April 27th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: |Comments Off on New Journal Article – Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

Applying Imaging to Study Infectious Diseases

Gayatri Gowrishankar, PhD Research Scientist Multimodality Molecular Imaging Lab Stanford University Alvaro A. Ordonez, MD Assistant Professor Department of Pediatrics Johns Hopkins University School of Medicine With the current COVID-19 pandemic causing global disruption, scientists around the world are working tirelessly to apply their expertise within the field

By |2020-06-03T12:56:20-04:00April 6th, 2020|Categories: Animal Models, Articles, Imaging, Molecular, Mouse, MRI, PET/CT, Rat|Tags: , , |Comments Off on Applying Imaging to Study Infectious Diseases

New Journal Article – Ultrasound-Induced Microbubble Cavitation via a Transcanal or Transcranial Approach Facilitates Inner Ear Drug Delivery

In a recent paper published in JCI Insight, researchers have demonstrated for the first time the feasibility of applying Ultrasound-induced Microbubble Cavitation via the external auditory canal as a technique to increase the efficiency of drug delivery to the inner ear. Effective treatment of auditory diseases, such as hearing loss and tinnitus, has become

By |2020-06-03T12:56:42-04:00March 23rd, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: |Comments Off on New Journal Article – Ultrasound-Induced Microbubble Cavitation via a Transcanal or Transcranial Approach Facilitates Inner Ear Drug Delivery

New Journal Article – Development of a Novel Superparamagnetic Nanoparticles to Quantify Nerve Density in Prostate Cancer and for Targeted Drug Delivery in the Same Model

In this journal article published in early February 2020 titled “Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer” in Science Advances, Huijuan You et al. discuss the development of their novel superparamagnetic iron oxide nerve peptide nanoparticles (PSN NPs) to image and quantify nerve density in a mouse

By |2020-06-03T13:01:32-04:00February 25th, 2020|Categories: Animal Models, Articles, Mouse, Rat, Telemetry, Tissue Oxygen|Tags: , |Comments Off on New Journal Article – Development of a Novel Superparamagnetic Nanoparticles to Quantify Nerve Density in Prostate Cancer and for Targeted Drug Delivery in the Same Model

New technology video: The CondoCell

How can researchers ensure their cells grow at optimal conditions when incubator doors open and close at infrequent times on a daily basis? Is there an easy way to prevent contamination of key cell lines in a shared incubator? Want to keep cells at optimal conditions even outside of an incubator (CO2 or Tri-gas)? The

By |2020-06-03T13:02:15-04:00October 30th, 2019|Categories: Articles, Cancer Research, Hypoxia, Lab Equipment, Molecular|Tags: |Comments Off on New technology video: The CondoCell

In vivo tissue oxygenation: How do I know which method is best for my research?

There are a variety of ways that researchers today can measure oxygenation of tissue in vivo. Unfortunately, while a range of options do exist, choosing which technology to use to measure tissue oxygenation is often difficult, even to those who have years of experience in the field. Here, we cover the four most prominent ways

By |2020-06-03T13:02:52-04:00October 18th, 2019|Categories: Animal Models, Articles, Micro-Vascular Flow, Mouse, Physiology, Rat, Telemetry, Tissue Oxygen|Tags: , |Comments Off on In vivo tissue oxygenation: How do I know which method is best for my research?

How modern hypoxia chambers and chemically defined media are changing the face of cancer research

Cancer micro-environments are essential in understanding cancer malignancy and can provide accurate insights into how therapies targeting tumors may respond. Looking into these micro-environments further, Scintica Instrumentation’s cellular oxygen expert, Justin Croft, teamed up with custom media specialist, Annie Cunningham, of InVitria to publish the article “How modern hypoxia chambers and chemically defined media are changing the

By |2020-06-03T13:03:17-04:00October 15th, 2019|Categories: Articles, Cancer Research, Hypoxia, Molecular|Tags: , , , |Comments Off on How modern hypoxia chambers and chemically defined media are changing the face of cancer research

A Tale of Two Tubes: Exploring the Causes of Cardiovascular Disease from the Arteries to the Gut

The Integrative Cardiovascular Physiology laboratory at Colorado State University investigates the underlying causes of cardiovascular abnormalities in the settings of obesity and nutrient excess. Obese individuals are at an increased risk for developing cardiovascular disease (CVD)1. Prior to overt clinical manifestation of CVD, the arteries of obese individuals (and other at-risk populations) begin to

By |2020-05-22T15:45:11-04:00September 11th, 2019|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Fish, Mouse, Physiology, Rat|Tags: |Comments Off on A Tale of Two Tubes: Exploring the Causes of Cardiovascular Disease from the Arteries to the Gut