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PET/CT: Frequently Asked Questions

What is PET/CT Imaging? PET/CT imaging is the combination of two distinct imaging techniques. a What is PET Imaging? PET, or positron emission tomography, is a look at the metabolic or biochemical activity present in a given anatomical region using radiotracers. a What is a radiotracer? A radiotracer is a chemical compound in which

By |2019-04-11T16:07:11-04:00April 11th, 2019|Categories: Animal Models, Articles, Cancer Research, Imaging, Mouse, PET/CT, Rat|Comments Off on PET/CT: Frequently Asked Questions

Cancer biology and High-Frequency Ultrasound: non-invasive identification, visualization, and quantification in a wide variety of preclinical tumor models

Ultrasound has become a widely used preclinical imaging modality that can be used to visualize a variety of internal structures within small animal models with high resolution (down to 30µm). This provides researchers with primary structural information in real-time allowing for the non-invasive quantification of organ/tumor parameters in both two- and three-dimensions, as well

By |2019-04-11T16:08:26-04:00March 7th, 2019|Categories: Animal Models, Articles, Cancer Research, Imaging, Molecular, Mouse, Physiology, Rat, Ultrasound|Comments Off on Cancer biology and High-Frequency Ultrasound: non-invasive identification, visualization, and quantification in a wide variety of preclinical tumor models

𝘐𝘯 𝘷𝘪𝘷𝘰 intermittent hypoxia: New chambers give researchers dynamic and controlled O₂ environment to enhance research

Intermittent hypoxia (IH), also referred to as hypoxia-reoxygenation, is a condition where periods of normal tissue oxygen pressure (normoxia) cycle with periods of low tissue oxygen pressure (hypoxia). This alternating lack of oxygen is associated with various forms of the respiratory illness, sleep apnea. Those afflicted with sleep apnea can see oxygen fluctuate dramatically

By |2019-03-06T12:29:31-04:00March 6th, 2019|Categories: Animal Models, Articles, Cancer Research, Hypoxia, Molecular, Mouse, Rat|Comments Off on 𝘐𝘯 𝘷𝘪𝘷𝘰 intermittent hypoxia: New chambers give researchers dynamic and controlled O₂ environment to enhance research

Investigating the role of metabolism in human induced pluripotent stem cell generation

This team of researchers in the Biology Department at Western University are investigating metabolic ways to increase efficiency of reprogramming adult cells to iPSCs. Embryonic stem cells are pluripotent, which means they can turn into any cell type found in the adult body and are therefore critical for human development1. Stem cells show great promise in

By |2019-03-01T15:28:47-04:00February 21st, 2019|Categories: Articles, Cancer Research, Hypoxia, Lab Equipment, Molecular|Comments Off on Investigating the role of metabolism in human induced pluripotent stem cell generation

Counting Highly Dense Colonies

Perhaps you’ve been there - looking at a colony formation assay (CFA) where there are hundreds (or thousands) of colonies of various sizes and wondering “how can I possibly count all of these colonies accurately”? The logistical problem becomes even more difficult when you realize you should only be counting colonies over 30μm and

By |2019-03-01T15:29:17-04:00February 4th, 2019|Categories: Articles, Cancer Research, Molecular|Comments Off on Counting Highly Dense Colonies

A Non-Invasive Method to Assess Coronary Flow Reserve

Coronary flow reserve (CFR) is a measure of the ability of the coronary arteries to increase blood flow to the myocardium via dilation during periods of stress.  CFR is reduced by age, as well as various disease states including coronary artery disease.  Given the small size and significant branching of these arteries, traditional methods

By |2019-03-01T15:29:35-04:00January 17th, 2019|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Fish, Physiology, Rat|Comments Off on A Non-Invasive Method to Assess Coronary Flow Reserve

Transverse Aortic Constriction (TAC): Why, how and the outcome as it relates to pressure overload-induced cardiac hypertrophy and/or heart failure

Chronic congestive heart failure, more commonly referred to as heart failure (HF), is a multifactorial cardiac disease which can affect the heart both structurally and/or functionally thereby impairing its ability to properly fill and eject blood from the ventricles. It is one of the leading causes of death with increasing incidence and prevalence rates,

By |2019-03-01T15:30:38-04:00December 7th, 2018|Categories: Animal Models, Articles, Cardiac Function, Cardiovascular Research, Mouse, Physiology, Transverse Aortic Constriction|Comments Off on Transverse Aortic Constriction (TAC): Why, how and the outcome as it relates to pressure overload-induced cardiac hypertrophy and/or heart failure

Normoxia isn’t normal: Conventional incubators generate more questions than they answer

Since the first CO2 incubators were made commercially available in the late 1960’s they have become a staple for researchers to grow and maintain cells in vitro. These chambers have been highly effective for this task; however, they do not take into account one significant factor - oxygen. Currently, there is a push from

By |2019-03-01T15:30:55-04:00November 26th, 2018|Categories: Articles, Cancer Research, Hypoxia, Lab Equipment, Molecular|Comments Off on Normoxia isn’t normal: Conventional incubators generate more questions than they answer

Re-evaluating manual colony counting: How automated counting is saving researchers time and effort

Manual colony counting method A typical manual counting scenario looks like this: The researcher finds an object and decides whether it is a colony. If it is determined to be a colony, the researcher then ascertains if it meets a minimum threshold to be a colony. If it does then 1 is added to

By |2019-03-01T15:32:27-04:00November 8th, 2018|Categories: Articles, Cancer Research, Lab Equipment, Molecular|Comments Off on Re-evaluating manual colony counting: How automated counting is saving researchers time and effort

Benchtop blood pressure: A fast, affordable and non-invasive technique

The capability to precisely and non-invasively measure the systolic and diastolic blood pressure, on top of heart rate and other blood flow parameters in rodents, can be of great clinical value to researchers. The non-invasive rat and mouse blood pressure measurement consists of using a tail-cuff placed on the tail to occlude blood flow.

By |2019-03-01T15:32:36-04:00November 7th, 2018|Categories: Animal Models, Articles, Cardiovascular Research, Lab Equipment, Mouse, Physiology, Rat|Comments Off on Benchtop blood pressure: A fast, affordable and non-invasive technique