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New Journal Article – Cell Proliferation Detected Using [18F]FLT PET/CT as an Early Marker of Abdominal Aortic Aaneurysm

Abdominal aortic aneurysm (AAA) is a localized dilatation of the abdominal aorta which shows limited symptomology prior to rupture. Once rupture occurs though, the results may be catastrophic leading to intense pain, loss of consciousness, and possibly death. Detection often occurs incidentally or through routine screening, and surgical intervention is generally limited to large

By |2020-06-26T14:20:38-04:00June 26th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: , |Comments Off on New Journal Article – Cell Proliferation Detected Using [18F]FLT PET/CT as an Early Marker of Abdominal Aortic Aaneurysm

(July 29, 2020) WEBINAR: Cancer Research in Small Animals: A Review of Recent Publications Using High Frequency Ultrasound

Zoom Registration Form Below July 29, 2020 11:00 AM – 12:00 PM (EDT) (UTC−04:00) This webinar hosted by Scintica Instrumentation will discuss the benefits of ultrasound imaging in cancer research. Ms. Tonya Coulthard will be the presenter of this webinar, she will touch on several topics throughout the presentation as

By |2020-06-26T16:35:09-04:00June 26th, 2020|Categories: Animal Models, Event, Imaging, Mouse, Rat, Ultrasound, Upcoming, Webinar|Tags: |Comments Off on (July 29, 2020) WEBINAR: Cancer Research in Small Animals: A Review of Recent Publications Using High Frequency Ultrasound

Intermittent Hypoxia (OSA) and sustained hypoxia can prompt inter-tissue circadian clock misalignment

Circadian clocks are present in most cells of the body and act to coordinate human’s daily physiology and behavior with the environment. This is important as circadian misalignment between the bodies clock and the environment has been connected to various pathologies. Here, a group from Israel has shown that circadian misalignment can also occur

By |2020-06-18T10:29:16-04:00June 17th, 2020|Categories: Animal Models, Articles, Hypoxia, Molecular, Mouse, Rat|Tags: |Comments Off on Intermittent Hypoxia (OSA) and sustained hypoxia can prompt inter-tissue circadian clock misalignment

(June 17, 2020) WEBINAR: Fluorescence 𝘪𝘯 𝘷𝘪𝘷𝘰 Endomicroscopy: Imaging and Analysis (Co-Hosted w/Invicro)

Advanced benchtop microscopes can deliver resolution on the order of nanometers. However, they are highly invasive and require hours to days of tedious sample preparation, increasing the possibility of artifacts. Imagine a microscope that can capture images in real time directly from a living animal! Slide Deck On

By |2020-06-17T13:10:27-04:00May 30th, 2020|Categories: Animal Models, Confocal, Event, Imaging, Mouse, Rat, Webinar|Tags: |Comments Off on (June 17, 2020) WEBINAR: Fluorescence 𝘪𝘯 𝘷𝘪𝘷𝘰 Endomicroscopy: Imaging and Analysis (Co-Hosted w/Invicro)

(June 10, 2020) WEBINAR: Aging and the Cardiovascular System; An in vivo and in vitro approach to the pre-clinical assessment of arterial stiffness

Almost one third of deaths world-wide can be attributed to cardiovascular diseases (CVD). More than half of those cases are related to systemic arterial hypertension (SAH). There are several risk factors that contribute to the development of SAH. Type II diabetes causes structural and functional damage to arterial walls, which leads to stiffness

By |2020-06-24T09:54:47-04:00May 29th, 2020|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Event, Mouse, Physiology, Rat, Webinar|Tags: , |Comments Off on (June 10, 2020) WEBINAR: Aging and the Cardiovascular System; An in vivo and in vitro approach to the pre-clinical assessment of arterial stiffness

WEBINAR: Cardiac Fibrosis – A Comprehensive Overview of Mechanisms, Tools and Potential Targets

This free webinar hosted by Scintica Instrumentation looked at the following: 1) Fibrosis– general introduction, 2) signaling pathways regulating cardiac fibrosis, 3) potential targets of cardiac fibrosis 4) techniques to measure cardiac fibrosis including using Doppler Flow Velocity measurements Slide Deck On Demand Q & A

By |2020-06-12T14:31:57-04:00May 25th, 2020|Categories: Animal Models, Cardiac Function, Cardiovascular Research, Event, Mouse, Physiology, Rat, Webinar|Tags: , , , |Comments Off on WEBINAR: Cardiac Fibrosis – A Comprehensive Overview of Mechanisms, Tools and Potential Targets

New Journal Article – Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

Circadian Rhythms lead to the coordination of a multitude of physiological, behavioural, and metabolic processes to the natural 24-hour periodicity of the earth’s rotation. In this paper from 2019 published in Molecular Metabolism, researchers demonstrated the important of an overall synchronized circadian clock network to maintain metabolic homeostasis. In mammals, many metabolic processes are

By |2020-06-03T12:56:00-04:00April 27th, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: |Comments Off on New Journal Article – Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

Applying Imaging to Study Infectious Diseases

Gayatri Gowrishankar, PhD Research Scientist Multimodality Molecular Imaging Lab Stanford University Alvaro A. Ordonez, MD Assistant Professor Department of Pediatrics Johns Hopkins University School of Medicine With the current COVID-19 pandemic causing global disruption, scientists around the world are working tirelessly to apply their expertise within the field

By |2020-06-03T12:56:20-04:00April 6th, 2020|Categories: Animal Models, Articles, Imaging, Molecular, Mouse, MRI, PET/CT, Rat|Tags: , , |Comments Off on Applying Imaging to Study Infectious Diseases

New Journal Article – Ultrasound-Induced Microbubble Cavitation via a Transcanal or Transcranial Approach Facilitates Inner Ear Drug Delivery

In a recent paper published in JCI Insight, researchers have demonstrated for the first time the feasibility of applying Ultrasound-induced Microbubble Cavitation via the external auditory canal as a technique to increase the efficiency of drug delivery to the inner ear. Effective treatment of auditory diseases, such as hearing loss and tinnitus, has become

By |2020-06-03T12:56:42-04:00March 23rd, 2020|Categories: Animal Models, Articles, Imaging, Mouse, Physiology, Rat, Ultrasound|Tags: |Comments Off on New Journal Article – Ultrasound-Induced Microbubble Cavitation via a Transcanal or Transcranial Approach Facilitates Inner Ear Drug Delivery

New Journal Article – Development of a Novel Superparamagnetic Nanoparticles to Quantify Nerve Density in Prostate Cancer and for Targeted Drug Delivery in the Same Model

In this journal article published in early February 2020 titled “Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer” in Science Advances, Huijuan You et al. discuss the development of their novel superparamagnetic iron oxide nerve peptide nanoparticles (PSN NPs) to image and quantify nerve density in a mouse

By |2020-06-03T13:01:32-04:00February 25th, 2020|Categories: Animal Models, Articles, Mouse, Rat, Telemetry, Tissue Oxygen|Tags: , |Comments Off on New Journal Article – Development of a Novel Superparamagnetic Nanoparticles to Quantify Nerve Density in Prostate Cancer and for Targeted Drug Delivery in the Same Model