Programmed death ligand 1 (PD-L1) is the principal ligand of the programmed death one (PD-1) receptor and is essential in the development of immune tolerance and prevention of autoimmunity. Unfortunately, PD-L1 is also expressed in many tumour types which is instrumental in allowing cancer cells to evade immune recognition. Immunohistochemistry may be used to
Overview: Dr. Lee will discuss how simultaneous PET and MR data acquisition using a fully integrated system, such as the SimPET-M7 simultaneous PET/MRI solution, can provide several advantages over sequential PET/CT for small animal imaging. He will also introduce the SimPET-M7 simultaneous PET/MRI solution for small animal imaging in this talk. Note: That
(February 23, 2021) WEBINAR: Neonatal model of transverse aortic constriction (nTAC) to induce pressure overload
Overview: Learning objectives: How to perform neonatal model of transverse aortic constriction (nTAC) to induce pressure overload in neonatal mice? How to confirm the surgery using Doppler Flow Velocity measurements? How to confirm the surgery and assess the outcome using echocardiography? What is the outcome of induced pressure overload at P1 vs P7?
(February 24, 2021) WEBINAR: Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury
Overview: Learning Objectives: PT-BsAbs can treat cardiovascular diseases PT-BsAbs redirect HSCs via pulmonary blood circulation to the heart Hematopoietic stem cells from the lungs can be used to treat heart injury Inhalation of PT-BsAbs had more therapeutic benefits than intravenous injection On Demand Slide Deck Q & A
(March 3, 2021) WEBINAR: The SuperArgus state-of-the-art preclinical PET/CT system: An overview of the technical specifications, unique product features and novel applications
Overview: Learning Objectives: Introduction to preclinical positron emission tomography Introduction to Sedecal The SuperArgus: product overview What makes the Sedecal systems unique Applications and current research On Demand Slide Deck These systems are ideally suited for pre-clinical imaging of small animals such as mice and rats, all
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(February 2, 2021) WEBINAR: Preclinical DXA for in vivo body composition and bone mineral density measurements
Overview: Topics discussed in this webinar included: What is DXA and How Does it Work iNSiGHT System & Software Overview Key Research Applications: Metabolic Bone Disease Arthritis Metabolic Disorders Musculoskeletal Diseases Drug Safety and Toxicology This webinar introduced the iNSiGHT preclinical DXA system from OsteoSys. The system is
(March 4, 2021) WEBINAR: Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
Overview: Key topics covered during this webinar included: Evaluating cardiac contractility using mean or peak aortic acceleration Investigating cardiac relaxation using mitral peak early velocity to peak atrial velocity ratio Interpreting myocardial perfusion capacity through coronary flow reserve at baseline and with disease or other conditions How Doppler Flow Velocity measurements can be
Overview: Learning Objectives: How to add optical imaging capabilities to your lab How to detect very few cells How to differentiate multiple signals within the same animal How to properly acquire and analyze data How to do ex vivo imaging…and much more In this webinar, Katie will answer the most frequently asked questions
Overview: Dr. Bogdanov will discuss how multimodality registration of optical and magnetic resonance imaging (MRI) in the same voxels of live tissue could be aided by paramagnetic contrast agents that provide optical clearing (OC) effect. We investigate the effects of gadobutrol (GB) and its combination with DMSO/water as potential OC agent for imaging