Supporting Cancer and Biomedical Research

Thanks to spectacular advances in cancer research, more than 16.9 million people in the US and millions more around the world are living with, through, and beyond their diagnoses – American Association of Cancer Research

Aspect Imaging M-Series™ Compact MRI Series

The M-Series™ Compact MRI systems enable high-resolution imaging without the need for special shielding, cryogens or water connections, making it a standalone system that can easily be placed within a core facility, laboratory, or inside an animal facility right next to other equipment or fixtures.

  • Simple to Operate – Requires no previous background in MR physics

  • Easy Installation – Easy to install with images being acquired on the first day

  • Requires no specialized infrastructure –No electricity is required to maintain the magnetic field, they utilize a permanent magnet made of neodymium

The M-SeriesTM high-performance, compact MRI systems from Aspect Imaging have been designed with the preclinical researcher in mind.

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Vilber Smart Imaging Newton 7.0

The Vilber Newton 7.0 is an innovative optical bioluminescence and fluorescence imaging system designed with the user in mind. It is ideal for in vivo, ex vivo and in vitro imaging applications, allowing for simultaneous imaging of multiple animals or samples at a time. It combines the best optics and animal handling features for optimum scientific images and results. Capable for large throughput studies, up to 5 mice at a time.

  • No Radiation – Does not require any radiation to acquire images

  • Powerful Fluorescence Excitation – Offers 8 excitation channels in the visible RGB and near-infrared spectrums.

  • Macro-imaging to large throughput studies –  intelligent darkroom architecture allows for fully automated movement of the camera (Z-axis) and animal pad (X/Y axis) to move through both the macro imaging FOV to the full FOV for imaging up to 5 mice

The Newton 7.0 is a highly sensitive optical imaging system dedicated to pre-clinical imaging of small animals in vivo, and may also be used on a variety of in vitro and ex vivo samples. It combines the best optics and animal handling features for optimum scientific images and results. The Newton 7.0 systems are capable of bioluminescence, fluorescence as well as 3D tomographic imaging.

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Sedecal’s SuperArgus PET/CT & Compact PET or CT

Sedecal’s SuperArgus PET/CT are state-of-the-art systems, varying in sizes to allow molecular imaging of small animals such as mice, rats, and marmosets, through to rabbits, and all the way up to non-human primates. The Compact systems can be either PET or CT, with the animal handling systems being interchangeable allowing for sequential image acquisition on the same animal. Both systems have:

  • State-of-the-art phoswich detectors – Provide true depth of interaction (tDOI) information resulting in and Highest resolution on the market; ≤1.0mm Uniform resolution across the entire field of view

  • Optimized reconstruction algorithms – FBP (Filtered Back Projection) completed in less than 5 seconds, 2D OSEM (Ordered Subset Expectation Maximization) completed in less than 1 minutes, 3D OSEM completed in less than 2 minutes

  • Self-shielded – Self-shielded design of the Compact CT system, meeting FDA guidelines, reducing infrastructure requirements for installation

Sedecal’s SuperArgus PET/CT and Compact PET or CT offer unique key benefits for different pre clinical studies.

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S- Sharp’s Prospect T1

The Prospect T1 is a cost effective high-frequency preclinical ultrasound system for mice, rats and other small animals, optimized to study the hemodynamics and vascular function at the laboratory benchtop instead of from inside a core imaging facility.  It produces high resolution images, with spatial resolution up to 30µm, and provides exquisite details of anatomical structures.

  • Well-equipped standard system-  includes B-mode, M-mode, Pulsed Wave/Tissue/Color/Power Doppler, and Contrast Mode; one single element probe (mouse or rat) and one imaging platform (mouse or rat)

  • Offline Software Analysis – By performing analysis offline on an office/analysis computer time on the system is reserved for image acquisition.

  • ECG Gated Kilohertz Visualization (EKV) mode– This mode allows for up to 190fps imaging of the heart; these images provide exquisite detail of the cardiac motion and may be used with any of the standard measurement tools available in regular B-mode imaging.

The Prospect T1 has been specifically designed for preclinical imaging of small animals including mice and rats. These species require very high resolution images (up to 30µm) to observe anatomical structures, and considerations to monitor changes in hemodynamics due to their high heart rates. This tablet based, high frequency, compact ultrasound system is a cost effective alternative to other preclinical ultrasound systems on the market, allowing individual labs to harness the power of this real-time imaging modality.

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Oxford Optronix’s OxyLite™ & OxyFlo™

One of the most powerful and unique features offered by Oxford Optronix tissue vitality monitors is the ability to measure tissue oxygen, laser-Doppler blood flow, and temperature simultaneously from the same tissue micro-region. This is achieved by combining counterpart monitors into a ‘stack’ arrangement and the use of unique, combined, multi-parameter sensors. The use in this way of a 4-channel OxyLite™ Pro XL and a 4-channel OxyFlo™ Pro XL device enables the collection of multi-parameter physiological data from up to four independent tissue sites at one time, providing unsurpassed data collection and productivity potential.  Applications in which Oxford Optronix OxyLite™ and OxyFlo™ monitors have been employed together for the simultaneous, single-sensor monitoring of tissue oxygen, blood perfusion, and temperature include:

  • Tumour Angiogenesis 

  • Vital organ Vitality during Transplantation and Shock Monitoring

  • Cerebral Vitality Monitoring During Stroke

  • Brain and Spinal Cord Injury Models

  • Tissue Flap Surgery and Wound Healing 

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  • Oxford Optronix - OxyLite and OxyFlo
  • Oxford Optronix - OxyLite Pro and OxyFlo Pro

IVIM Technology’s  IntraVital Microscopy (IVM)

Intravital microscopy is a technique that enables you to directly observe the movement of live cells that make up living tissue in vivo. With this technique, it is possible to distinguish an individual cell among a large number of cells in various organs, which is not possible with conventional biomedical imaging technologies such as MRI or CT, and to track the movement of each cell in three dimensions in real-time. IVIM Technology’s All-in-One IntraVital Microscopy (IVM) system is extensively optimized and carefully engineered to provide superb performance in the intravital imaging of live animal models in vivo.

  • Integrated Temperature Support-  Ensures animal’s well being throughout the imaging session and consistency between animals within a study

  • Integrated inhaled anesthesia– Ensures ease of animal handling and consistent plane of anasthesia

  • Animal Motion Compensation – Provides enhanced image quality on organs which may be affected by respiratory motion

  • User-Friendly design –  both software and hardware that allows for ease of use, and reproducible results

  • 4- Color Simultaneous Imaging –  Confocal / Two-Photon Modes – Allows users to track the movement of several cells in vivo to better understand the biological processes being examined.

  • Ultrafast RoTating Polygonal Mirror Scanner –  Allows for ultrafast uniform laser – beam scanning with uniform excitation illumination over the entire field of view (FOV). It also enables ultra-high speed in vivo  imaging

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Baker Ruskinn’s VelO2x Hypoxia Chamber

The VelO2x system has been engineered to provide an isolated and highly controlled oxygen environment to small animal models (ie mouse and/or rat). By directly mimicking the oxygen conditions experienced across a wide variety of disease or treatment models, the VelO2x grants researchers a better understanding of how O2 levels affect various conditions such as sleep apnea, systemic hypertension, pulmonary dysfunction, and ischemia to name a few.

  • Full Control of Oxygen Levels – Researchers have the ability to control Olevels from 0.1% to 23.0% (can be increased). Unlike other systems, the VelO2x comes standard with the ability of static and dynamic control of O2.

  • Rapid Changes in O2 Levels– In the 31L chamber, oxygen can be ramped down from 20.9% to 6% in 15 seconds and ramped up from 6% to 20.9% in 35 seconds. The 66L chamber can do 20%.9% to 6% in 30 seconds and from 6% to 20.9% in 45 seconds

  • Ease of Use – A fully integrated touch screen makes adjusting all parameters needed for a particular experiment easy. All data of O2 and COlevels are saved continuously to a USB and can be transferred to any computer for analysis or for validation and verification of animal welfare.

While the VelO2x system has been optimized for rapid transitions in Ooften seen in acute hypoxia studies, its functionality allows it to be used for chronic studies as well.

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Cytosmart’s Live-cell Imaging Systems 

CytoSMART is an innovator in kinetic live-cell imaging. Combining compact and fast imaging hardware with powerful image analysis algorithms supported by cloud computing. The Lux2 is a highly compact, easy to use, and affordable inverted microscope for bright-field live-cell imaging so it can be used in every biological laboratory.  The Omni has been developed as an automated bright-field lab microscope that visualizes whole culture vessels and can even be used within a standard CO2-incubator. The Lux3 FL fluorescent cell imaging device allows researchers to track dynamic cellular processes by taking high-quality images to create real-time time-lapse movies.

  • Effortless image analysis and data storage –  The CytoSMART Lux2 can be set to record images at specific intervals for minutes, hours and days. In fact, it is one of the few systems that can run for weeks on end. All recorded images are able to be sent to the CytoSMART Connect Cloud

  • Perform analysis at desired culturing environment– The CytoSMART Omni is designed for an incubator environment. Live-cell imaging systems require environmental control during the experiment. To ensure the proper environmental conditions, users can place the compact Omni inside any standard cell culture incubator.

  • Ease of Use – A fully integrated touch screen makes adjusting all parameters needed for a particular experiment easy. All data of O2 and COlevels are saved continuously to a USB and can be transferred to any computer for analysis or for validation and verification of animal welfare.

  • Live Insight in Cellular Processes– The Lux3 FL fluorescence imaging microscope automatically creates time-lapse movies that contain many cellular features

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American Association for Cancer Research

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